Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"lcmv"”.
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The Steered Auxiliary Beam Canceller for Interference Cancellation in a Phased Array
… are the Linearly Constrained Minimum Variance (LCMV) beamformer and the Side-Lobe Canceller (SLC). LCMV provides better performance than SLC, but comes with much higher computational costs. The Steered Auxiliary Beam Canceller (SABC) presented in this thesis is a new algorithm developed to …
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Multigenic Regulation of the Shutdown of Immune Responses
… T cells following both acute and chronic LCMV infection. Following acute LCMV infection, we observed a transient delay in the contraction of antigen-specific CD8+ T cells in Bim-/- mice compared to wildtype, however contraction eventually ensues and the number of cells only remains …
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Der Einfluss von Chemokinen auf die Migration von naiven und Effektor-CD8-T-Zellen in der Milz
… des Lymphozytären Choriomeningitis Virus (LCMV) verwendet. Durch die Verwendung eines allelischen Thy1-Markers konnte im adoptiven Transfersystem zwischen den LCMV-spezifischen Donorzellen der tg Mäuse und den Rezipientenzellen normaler Mäuse unterschieden werden. Nach einem Transfer fanden …
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Arenaviruses: the Role of Antigen Presenting Cells (APC) in Persistence and Immunopathology
… persistence and immunopathology using the LCMV model. The LCMV model is a well-established model system for studying the immune system and its interaction with pathogen. It has contributed to some fundamental discoveries in the field of immunology and virology; for example, understanding …
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REDOX REGULATION OF B CELL ACTIVATION AND THE ANTI-VIRAL HUMORAL IMMUNE RESPONSE
… by treating lymphocytic choriomeningitis virus (LCMV) infected mice with Mn(III)tetrakis(4-benzoic acid)porphyrin chloride (MnTBAP), a superoxide dismutase mimetic, from days 0-8 postinfection. On day 8 postinfection, splenic LCMV specific IgM and IgG antibody secreting cells (ASC) were 22- and …
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USING UNSUPERVISED LEARNING TECHNIQUES TO UNDERSTAND CD8+ T CELL DIFFERENTIATION DURING VIRAL INFECTION AND TUMOR DEVELOPMENT
… (acute) or Clone 13 (chronic) strains of LCMV, or MHV68 expressing the LCMV epitope DbGP33-41. By performing k-means clustering and generating self organizing maps (SOM), we observed increased short-lived effector-like and terminally-differentiated CD8+ T cells following latent infection. …
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Spezifische Eliminierung von Tumorzellen durch T-Zellen : Bedeutung der T-Zellvorläuferfrequenz
… des Virus der lymphozytären Choriomeningitis (LCMV), welches als Tumor Assoziiertes Antigen (TAA) dient. ALB1-tg Mäuse exprimieren GP33 auf den Hepatozyten und zu einem geringeren Anteil im Thymus. Die Expression des GP33 Transgens im Thymus der ALB1-tg Mäuse führt zu einer partiellen Deletion …
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Differentiation into Effector Cells with Distinct Memory Fates: Contributions of Viral Dose and Functional Avidity
… response generated following poxvirus or LCMV infection, SLEC were of higher functional avidity than their MPEC counterpart. Over time however, SLEC exhibited a decrease in peptide sensitivity in mice infected with VV but not LCMV. The decrease in functional avidity in SLEC was independent …
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Cytokine priming enables triggering of naive auto-reactive CD8[superscript +]T cells by weak agonist ligands of the TCR
… (GP33) of lymphocytic choriomeningitis virus (LCMV). We show that, following priming with IL-21 in the presence of IL-7 or IL-15, P14 cells gain the ability to respond robustly to modified peptide ligands that possess weak agonistic activity towards unprimed P14 cells. Furthermore, …
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Mechanismen der CD8+ T-Zell-vermittelten Tumorabwehr beim B16 Melanom der Maus
… des Lymphozytären Choriomeningitis Virus (LCMV) transfiziert worden waren (Prévost-Blondel et al., 1998). Weiterhin wurden T-Zell-Rezeptor (TCR) transgene Mäuse eingesetzt, bei denen die Mehrzahl der CD8+ T-Zellen einen GP33-spezifischen T-Zellrezeptor exprimiert. <br>Die therapeutische …
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Regulation of Anti-Viral Cd8+ T Cell Responses by the Pd-1 Pathway
… and recall capacity. Similarly, during chronic LCMV infection, PD-1 deficient CD8+ T cells were more dysfunctional than their WT counterparts. Permanent absence of PD-1 dramatically dysregulated lineage dynamics and long-term stability of exhausted CD8+ T cell populations through a mechanism …
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Etablierung eines infizierbaren Kleintiermodells zur Untersuchung von HIV-Nef
… mit lymphozytärem Choriomeningitis Virus (LCMV) eine delayed type hypersensitivity (DTH) Reaktion in der Fußsohle von Mäusen induziert werden kann. Tiere, die zuvor neonatal mit Mo-NL infiziert worden waren, zeigten im Vergleich zu Kontrolltieren eine reduzierte CD4-vermittelte …
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Role of Multiple Toll-Like Receptor Activation in Regulating Cytotoxic T Cell Priming to Lympocytic Choriomeningitis Virus Infections
… alters immunodominance hierarchies of LCMV epitopes as a result of reduced uptake of cell-associated antigens and reduced cross-presentation of NP396 consequently suppressing NP396-specific CD8+ T cell responses. These findings are significant as they highlight a new role for TLR …
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Charakterisierung monoklonaler Antikörper gegen die murine Fibrosarkomzellinie MCA102 und Rolle der B-Zellen in diesem Tumormodell
… <br>des Lymphozytären Choriomeningitis Virus (LCMV) diente in diesem System <br>als tumorassoziiertes Modellantigen. <br>Um den Einfluß von B-Zellen auf die Tumorimmunität zu untersuchen, wurde das <br>MCA102GP33-Tumorwachstum in C57/BL6-Mäusen (B6-Mäusen) und B-Zell defizienten <br>JHT-Mäusen …
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Evolution of adaptive immune response from acute to chronic phase of hepatitis C virus infection
… clear contrasts with previous reports in murine LCMV models. The findings offer novel insights into our understanding of the immunopathgenesis of primary HCV and into HCV vaccine design.
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Charakterisierung der Abspaltung und des Schicksals der Signalsequenz des Glykoproteins des lymphozytären Choriomeningitis Virus
… SS des lymphozytären Choriomeningitis Virus (LCMV) Glykoproteins pGP-C (SSGP-C) untersucht. In einem zellfreien in vitro Translations-/Translokationssystem wurde ein Fusionsprotein, das aus der SSGP-C und dem reifen Teil des zellulären sekretorischen Proteins pre-Prolaktin besteht, nach dem …
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Low-Frequency Sonophoresis Assisted Cancer Immunotherapy
… LFS immunized mice was investigated with a viral LCMV challenge months after a single immunization. Following the viral challenge, LFS-immunized mice had a much faster recall response of more than 24 hours ahead of, and an order of magnitude higher expansion of CTLs than, both the priming phase …
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Statistical Model Based Multi-Microphone Speech Processing: Toward Overcoming Mismatch Problem
… construct linearly constrained minimum variance (LCMV) beamforming, which can be easily extended with the EMB framework. Because we perform a two-step approach, estimating RIR first and applying a demixing filter, without introducing more taps in the frame for adaptation purposes, we can have good …
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Intrinsic Mechanisms that Regulate T Cell Homeostasis and Function
… and enhanced mTOR activity. In response to LCMV infection, DGK-deficient CD8+ T cells expand more aggressively and produce elevated amounts of anti-viral cytokines, which results in reduced viral titers in DGK-deficient mice 7 days after infection. Additionally, we found that while DGK …