Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 21 for “"layer 5"”.
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Optical imaging of dendritic spikes in apical oblique dendrites of layer 5 pyramidal neurons
… functional role of apical oblique dendrites of layer 5 pyramidal neurons (L5PNs) are less understood. In this thesis, I aim to understand to functional role of thin apical oblique dendrites of L5PNs in the cortex. Using a previously published multi-compartment model of a L5PN, I first …
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Optical imaging of dendritic spikes in apical oblique dendrites of layer 5 pyramidal neurons
… functional role of apical oblique dendrites of layer 5 pyramidal neurons (L5PNs) are less understood. In this thesis, I aim to understand to functional role of thin apical oblique dendrites of L5PNs in the cortex. Using a previously published multi-compartment model of a L5PN, I first …
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Layer specific differences in the mouse auditory corticocollicular system
… streams emanating from auditory cortical layer 5 and layer 6 that influence the auditory midbrain. To examine the functional properties of neurons in these two layers that project to the midbrain, we performed three sets of experiments. First, to determine whether these projections have …
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Spontaneous activity in the mouse visual cortical slice: biophysical characterization and pathophysiology
… slices exhibit increased spiking activity in layer 5. Critically, this hyperactivity phenotype is rapidly reversed not only by treatments known to restore elevated rates of protein synthesis to WT levels, but also by the protein synthesis inhibitor cycloheximide. Therefore, rapidly turned over …
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A model for cerebral cortical neuron group electric activity and its implications for cerebral function
… makes use of the dynamic properties of the layer 5 network to explain intra-cortically generated augmenting responses, restful alpha, slow wave (< 1Hz) oscillations, and disinhibition-induced seizures. Based on recent cellular evidence, we propose a hierarchical binding mechanism in tufted …
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Interlaminar Interactions in the Cat Visual Cortex (Laminae, Columns)
… is the projection of cells in supragranular layers to cells in the infragranular layers. By recording from cells in the infragranular layers during synaptic inactivation of layers 1-3, I have examined the possibility that this projection may confer certain receptive field properties upon …
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TRPM5 Channels Contribute to Persistent Neural Activity and Working Memory
… into intrinsic persistent neural firing in PFC layer 5 pyramidal neurons. I hypothesize that CAN channels are responsible for the intrinsic properties that mediate persistent neural activity in PFC layer 5 neurons. During muscarinic receptor activation, bursts of action potentials will lead to …
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Critical requirements for NMDA receptors in experience-dependent plasticity in the visual cortex
… plasticity. First, I determined a layer-specific requirement for NMDA receptors in stimulus-specific response potentiation (SRP), which is a model for the plastic changes that may underlie perceptual learning. SRP acquisition requires NMDA receptors in the cortex, and it can be …
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Synaptic morphology, function, and regulation in a paediatric-onset neurodegenerative disorder
… the morphology and number of dendritic spines on layer 5 pyramidal neurons in the cerebral motor cortex. 2. Elucidate the biological impact of synaptic dysfunction on neuronal activity by electrophysiology. 3. Determine the underlying mechanisms contributing to dendritic spine dysgenesis/loss. 4. …
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Cellular and Synaptic Morphology of Golgi -Impregnated Cortical Neurons in Patients With Schizophrenia
… alterations differ across brain region, cortical layer, cell type, or antipsychotic treatments. Formalin-fixed tissue blocks from frontopolar cortex, Area 10, and primary visual cortex, Area 17, were acquired from a pool of 16 subjects with chronic schizophrenia and 22 normal comparison subjects. …
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Deep Molecular Characterization of Human Cortical Cell-Types
… routinely isolated cell-types, which include layer 2/3, layer 4, region specific populations of layer 5, termed layer 5 region-specific (layer 5rs), layer 5a, as well as layer 6a, and layer 6b excitatory pyramidal neurons, VIP, LAMP5, RELN, and PVALB expressing interneurons, astrocytes, …
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Role of the Transient Receptor Potential Channels in Modulating Prefrontal Cortical Excitability and the Behavioral Responses to Cocaine
… associated with drug addiction. We show that layer 5 pyramidal neurons in the PFC exhibit a prolonged depolarizing response to Gq-coupled receptor activation, which produces a period of heightened excitability of the cell following brief bursts of action potential activity. This burst …
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Characterizing Effects of Sphingosine-1-Phosphate Receptor 1 Activation in Subtypes of Central Amygdala Neurons and Effects of Prenatal Methadone Exposure on Motor Cortex Neurons in Mice
… of PME on primary motor cortex (M1) output layer 5 (L5) neurons, which encompass the major cortical output pathway for motor control. My findings provide the first evidence that PME disrupts neuronal firing, subthreshold properties, and strength of local inputs onto M1 L5 neurons in …
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Designing Enhanced Nonlinearity in Plasmonic Devices with Epsilon-Near-Zero Films
… an ultrathin indium tin oxide epsilon-near-zero layer (5–50 nm), and a dielectric-loaded surface plasmon polariton waveguide. Finite element method simulations were performed in COMSOL Multiphysics 6.2 using the Wave Optics Module. Parametric sweeps over epsilon-near-zero layer thickness, metal …
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Functional and ultrastructural investigation of mouse and human dendritic spines
… Of 2,234 spiny synapses from adult mouse layer 5 pyramidal neurons, a surprisingly large fraction (~25%) lacked AMPA receptors. These putative silent synapses were located at the tips of thin dendritic protrusions that lack the distinct head of conventional spines, known as filopodia, …
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Granular retrosplenial cortex layer 2/3 generates high frequency oscillation events coupled with hippocampal sharp wave-ripples and Str. LM high gamma
… brain region. In the hippocampal CA1 pyramidal layer local field potential (LFP), these processes take the form of theta and sharp wave ripples (SPW-Rs) for encoding and consolidation, respectively. As an animal runs through an environment, neurons become active at specific locations in the …
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Transcriptomic Signatures of Projection Class Neurons for Vocal Control
… comparisons. In the marmoset, I identified layer 5 extratelencephalic-projecting (L5 ET) excitatory neurons of orofacial and hindlimb primary motor cortex. Compared to L5 ET hindlimb neurons, orofacial L5 ETs showed low fold, though significant, molecular specializations, including …
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Selective Neuronal Vulnerability in Neocortices from Patients with C9ORF72-related Neurodegeneration
… 3). Upper motor neurons (herein called L5 ETs: layer 5 extratelencephalic-projecting excitatory neurons) were expected to display pathology in c9HRE and served as a positive control. Other vulnerable neuronal populations were identified by examining neurons with similar transcriptomic responses …
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Assessment of oxygen sources and sinks in the northern Gulf of Mexico using stable oxygen isotopes
… July 2002, showed that productivity in the mixed layer (5 to 10 m) was not homogeneous. Calculated P/R exceeded 1 only in the surface layer, while at 5 m P/R was approximately 1 and at a depth of 10 m, P/R was less than 1. Additionally, hypoxic conditions were only detected within 5 m of the …
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Cellular and synaptic pathophysiology in a rat model of Fragile X syndrome
… al., 2009). Using retrograde tracing, we showed layer 5 pyramidal neurons that provide long-range connections to the basal amygdala were intrinsically hypoexcitable in Fmr1 KO rats. This phenotype could possibly be explained through homeostatic changes in the axon initial segment which regulates …
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