Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 4 of 4 for “"lavendamycin"”.
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NAD(P)H:QUINONE OXIDOREDUCTASE (NQO1)-DIRECTED LAVENDAMYCIN ANTITUMOR AGENTS: STRUCTURE-BASED DESIGN, MOLECULAR MODELING AND STRUCTURE-ACTIVITY STUDIES
… antitumor drug development. We hypothesized that lavendamycins, quinolinedione antitumor antibiotics, can be activated by NQO1 in cancer cells that overexpress NQO1 to exhibit selective toxicity toward those cells. The effects of functional group changes on the metabolism of lavendamycins by …
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NAD(P)H:QUINONE OXIDOREDUCTASE (NQO1)-DIRECTED LAVENDAMYCIN ANTITUMOR AGENTS: STRUCTURE-BASED DESIGN, MOLECULAR MODELING AND STRUCTURE-ACTIVITY STUDIES
… antitumor drug development. We hypothesized that lavendamycins, quinolinedione antitumor antibiotics, can be activated by NQO1 in cancer cells that overexpress NQO1 to exhibit selective toxicity toward those cells. The effects of functional group changes on the metabolism of lavendamycins by …
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Structure and function of glutamate transporters
… NQO1 used computational molecular docking of two lavendamycin analogues into the NQO1 active site. Here we showed that relative scores of docked poses of the analogues were consistent with in vitro evaluations. All the studies presented in this dissertation were collaborative efforts that linked …
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Structure and function of glutamate transporters
… NQO1 used computational molecular docking of two lavendamycin analogues into the NQO1 active site. Here we showed that relative scores of docked poses of the analogues were consistent with in vitro evaluations. All the studies presented in this dissertation were collaborative efforts that linked …