Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"lateral gene transfer"”.
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Using Evolutionary Genomics to Elucidate Parasite Biology and Host-Pathogen Interactions
… exploits phylogenomic approaches to identify genes and gene families likely to be important in the biology of apicomplexan parasites, including Plasmodium (the causative agent of malaria) and Toxoplasma (a leading source of congenital neurological birth defects, and a prominent opportunistic …
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Adaptive Evolution of Surface Proteins in Microbial Pathogens: Lyme Disease Pathogens (Borreliella sp.) and Human Immunodeficiency Virus Type 1 (HIV-1)
… Pathogens respond to host immune pressures with genetic changes in surface proteins through mechanisms including point mutations, recombination, gene duplication and loss, and lateral gene transfer, resulting in novel antigenic variants and antigenic diversity. This continuous adaptation helps …
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Genes and structural proteins of the phage SYN5 of the marine cyanobacteria, Synechococcus
… hosts may have access to a global pool of genes, albeit at different levels. Marine cyanobacteria of the genera Prochlorococcus and Synechococcus are numerically dominant photosynthetic cells in the large oligotrophic gyres of the open oceans, and contribute an estimated 30% to the oceanic …
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Lateral Transfer of DNA in Protocell-like Synthetic Cells
… whether electroporation can mediate the transfer of DNA into and between synthetic cells, potentially enabling gene expression in initially DNA-free compartments. Both TXTL and PURE-based cell-free expression systems were encapsulated in lipid in order to evaluate fluorescence as a proxy …
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Molecular and ecological characterisation of Escherichia coli from plants
… was undertaken combining phenotypic and phylogenetic analyses of E. coli isolates from salads grown in the UK and the faeces of mammalian hosts. In vitro phenotypic profiling revealed significant differences according to the source of isolation: strains from plants were in the majority from …
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Microbial Evolution In Sea Ice: Communities To Genes
… hypotheses on the potential for increased lateral gene transfer by conjugation, transduction, or natural transformation in sea ice, addressed in Chapter 3 by measurement of the concentrations of bacteria, viruses, and extracellular free DNA in natural sea ice. These hypotheses were …
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An Integrated Approach to Improving Efficiency in Photosynthetic Microbial Systems
… with their rapid growth rates and amenability to genetic modifications, merit research of cyanobacteria for roles in mitigating greenhouse gas emissions and carbon capture and sequestration. Despite these favourable attributes, cyanobacterial bioenergy has yet to become successful at an industrial …
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Examination of the nematostella vectensis holobiont by comparative bacterial genomics and metatranscriptomics
… that holobiont-specific orthologous groups (i.e. gene orthologs found only in N. vectensis-associated bacterial genomes and absent in closely related genomes of the same genus/family) were shared across the populations examined. Further, no evidence of lateral gene transfer or shared phage or …
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HORIZONTAL GENE TRANSFER (HGT) AND SPHAGNUM FALLAX: A PHYLOGENETIC LOOK INTO THE OCCURRENCE, PREVALENCE, AND IMPORTANCE OF HORIZONTAL GENE TRANSFER IN A BOG MOSS
Horizontal gene transfer (HGT) is a biological process that involves any transmission of genetic material that isn't vertical in nature. HGT occurs frequently between prokaryotes and plays a significant role in prokaryotic evolution. This process is also known to occur between symbiotic bacteria …
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Cloning and characterization of a novel ferritin from the marine diatom Pseudo-nitzschia multiseries
… often limits phytoplankton biomass. Recently, gene sequences encoding ferritin, a nearly ubiquitous iron storage and detoxifying protein, have been identified in pennate diatoms such as Pseudo-nitzschia, but not in other Stramenopiles (which include centric diatoms, brown algae and some protist …
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Specificity and evolution of bacterial two-component signal transduction systems
… and divergence of a relatively small number of gene families has provided the raw material enabling cells to quickly increase their signaling capacity. After duplication, however, all pathway components are identical in sequence and function. To evolve a new role, the pathways must become …
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Functional Genomic Examinations Of Interactions Between Common Members Of The Human Gut Microbiota
… Bacteroidetes' genomes contain large groups of genes responsible for: i) sensing, binding, and metabolizing the varied polysaccharides that they encounter in the distal intestine; and: ii) constructing their polysaccharide capsules. These portions of their genomes have been shaped by lateral …
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Diversity of methane and short chain hydrocarbon degrading bacteria with an emphasis on methane biofilter systems
… cell genomes containing new CuMMO-encoding genes. CuMMOs are encoded by three genes, usually in an operon of xmoCAB, and oxidize ammonia, methane, and short chain alkanes and alkenes. To examine the evolutionary history of CuMMOs, phylogenetic inferences and compositional genome analyses …
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Computational methods for multi-omic models of cell metabolism and their importance for theoretical computer science
… shifts in its biochemical network and in the gene expression level. However, gene expression profiles do not provide a comprehensive understanding of the cellular behavior. Examples are the cases in which similar profiles may cause different phenotypic outcomes, while different profiles may …
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Genetic diversity and its consequences for light adaptation in Prochlorococcus
… cells thrive across diverse environments, their genetic differences can reveal what genes are essential to survival in a particular environment. Prochlorococcus, a cyanobacterium that dominates the open ocean, offers an opportunity to explore such differences. Its diversity is examined here, …
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Host-Microbe Relations: A Phylogenomics-Driven Bioinformatic Approach to the Characterization of Microbial DNA from Heterogeneous Sequence Data
… a vanishingly small constituent within a heterogeneous mixture of microbial and host sequences. Genomic analyses typically avoid the bacterial sequences in order to obtain a genome sequence for the host. Metagenomic analysis typically avoid the host sequences in order to analyze community …
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Bioengineering of S-layers: molecular characterization of the novel S-layer gene sslA of Sporosarcina ureae ATCC 13881 and nanotechnology application of SslA protein derivatives
… per second during the cell growth, the S-layer gene promoters are among the strongest prokaryotic promoters at all. However, little is known about factors regulating the expression of S-layer genes, furthermore, no experimental identification of other upstream regulatory sequences except for …