Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"latent reservoir"”.
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Dynamics of the HIV-1 Latent Reservoir
… cells. Despite the efficacy of ART, long lived latently infected cells persist, with an estimated half-life of 44 months, and circulate throughout the infected host necessitating life-long treatment. These cells, known as the latent reservoir, contain an integrated form of the HIV genome (HIV …
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Single Cell Analysis of the HIV-1 Latent Reservoir
… by the persistence of rare, long-lived, latently infected cells. These cells, called the latent reservoir, are thought to resist immune clearance and viral cytopathic effects by harboring a transcriptionally quiescent integrated HIV-1 provirus. As a result, interruption of suppressive …
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Characterizing the cellular latent reservoir of HIV-1 and the effect of immune activation on characteristics of the reservoir
… of viraemia. This is due to the formation of a latent reservoir that is long-lived and stable over time, precluding HIV-1 cure. The factors affecting reservoir formation, establishment, and kinetics are not fully understood. Furthermore, differences exist at the population level in disease …
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Development of a Modular Anti-HIV Transducer Protein
… of treatment, virus level rebound due to the latent reservoir of the virus in a small percentage of infected cells. New approaches to eradicate the HIV infection are mainly targeting the latent reservoir cells. The combinations of the drugs that activate latently infected cells and …
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Integration Sites in the Persistence of Latent HIV-1
… to HIV cure is the persistence of long-lived latently infected CD4+ T cells. Collectively known as the latent reservoir, these cells carry integrated HIV-1 proviruses that are transcriptionally quiescent and are thus able to evade host immunity and virus-induced cell death. Cellular and …
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Efficacy of Antibody and T cell Therapies for Highly Mutable Viruses like Human Immunodeficiency
… time can potentially clear rare strains from the latent reservoir which are likely to escape T cell responses resulting in viral rebound. We also describe a strong relation between the outcome of treatment and the diversity of the reservoir of latently infected cells, which suggest that the best …
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Therapeutic Uses of Broadly Neutralizing Anti-HIV-1 Antibodies in Humanized Mice
… are refractory to current therapies—termed the latent reservoir. New therapeutic approaches to clear latent HIV-1-infected cells are necessary to achieve cure. In the first part of this thesis, I show that HIV-1 mutates and diversifies at the expected rate within humanized mice (hu-mice) and …
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The Emergence of Diverse Drug-Resistance Mechanisms from Drug Tolerant Cancer Persister Cells
… state does not limit--and may even provide a latent reservoir of cells--from which drug-resistance heterogeneity can emerge.
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A TOLL-LIKE RECEPTOR-INDUCIBLE AND B CELL-SPECIFIC ENHANCER REGULATES MURINE GAMMAHERPESVIRUS 68 LATENCY AND REACTIVATION
… carcinomas, and lymphomas. B cells are the main latent reservoir of gammaherpesviruses. A central question is how B cell signaling regulates viral gene expression during establishment and reactivation from latency. The MHV68 M2 gene, a proposed functional analog of the EBV LMP2A and KSHV K1 …
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Cell intrinsic innate immunity protein RPRD2 restricts transcription from the HIV-1 LTR in human cell lines
… HIV replication under control, however, the latent reservoir remains unaffected, thus therapy is never curative. The establishment and persistence of latency are complex and still incompletely characterised. Host factors that repress retroviral transcription are thought to be involved in this …
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Development of one-step single-cell RT-PCR for the massively parallel detection of gene expression
… This relapse is attributed to the presence of a reservoir of latently infected cells, such as resting CD4+ T-cells. The latent reservoir in resting memory CD4+ T-cells has been estimated to decay with a half-life of as long as 44 months, thus hindering the eradication of HIV. Current knowledge of …
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HETEROGENEITY OF LATENCY ESTABLISHMENT IN DIFFERENT HUMAN CD4+ T CELL SUBSETS STIMULATED WITH INTERLEUKIN-15
… Therapy (HAART) treatment, a pool of latently infected cells persists and reactivates to produce viral particles if antiretroviral therapies are stopped or discontinued. This so-called latent reservoir is established mainly in CD4+ T memory ad naïve cells early during infection under …
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Droplet digital PCR detection and next-generation sequencing of HIV-1 in breastmilk of breastfeeding women on antiretroviral treatment
Persistence of HIV-1 in a stable latent reservoir in breastmilk has been associated with low- level mother to child transmission despite maternal antiretroviral therapy (ART). We aimed to evaluate and optimize the sensitivity of HIV-1 DNA quantitation in breastmilk using droplet digital PCR (ddPCR) …
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Enrichment and Transcriptome Analysis of CD4+ T Cell Clones Harboring Intact HIV-1 Proviruses
… The barrier to HIV-1 cure is the HIV-1 reservoir, a scarce pool of HIV-1 infected CD4+ T cells that has a very long lifetime, can multiply, and is not affected by antiretroviral therapy. These persisting infected cells have been the focus of HIV research, with the aim to identify …