Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 39 for “"latent infection"”.
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Virus-Host Interactions during Epstein-Barr virus Latent Infection of B cells
<p>Epstein-Barr virus latently infects over 90% of the adult global population. While it generally results in a completely asymptomatic lifelong infection, EBV is associated with and the causative agent of several human malignancies, particularly in cases of immune suppression. There is extensive …
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DEVELOPMENT AND MODULATION OF IMMUNE RESPONSES TO LATENT INFECTION IN THE CENTRAL NERVOUS SYSTEM
Infection in the central nervous system (CNS) and conversion to a more quiescent state is a shared feature of many persistent pathogens. The parasite Toxoplasma gondii forms long-lived cysts predominantly in neurons, which is considered important for immune evasion. However, whether neuronal cysts …
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CD68-positive tumour associated macrophages, PD-L1 expression, and EBV latent infection in a high HIV-prevalent South African cohort of Hodgkin lymphoma patients
… survival) and histopathological features (EBV latent positivity and subtype of HL). Methods We stained archived lymph node specimens from 77 patients diagnosed with HL for CD68 and PD-L1. Stains were graded as: CD68 low (≤25%), CD68 high (>25%), PD-L1 low (≤50%), and PD-L1 high (>50%). …
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Investigating the Role of Viral Long Non-Coding RNAs During Human Cytomegalovirus Latency
… is a ubiquitous human herpesvirus. Primary infection with HCMV in healthy individuals is generally asymptomatic but the virus is never cleared and can go on to establish lifelong latency in cells of the early myeloid lineage. During latency, the virus reduces its gene expression programme …
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Detection of HCMV viral IL-10 (vIL-10) in healthy blood donors
… UL111A gene is expressed during both lytic and latent infection, and at least two protein isoforms are produced. During lytic infection, the full length transcript yields cmvIL-10, a potent immunosuppressive viral ortholog of human IL-10 (hIL-10). Alternative splicing of the UL111A transcript …
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Investigating the Role of Human Cytomegalovirus Protein LUNA in Regulating Viral Gene Expression during Latency
… herpesviruses, the virus establishes a lifelong latent infection following host exposure, which has the potential to reactivate periodically and contribute to recurrent disease processes. In individuals with weak or compromised immune systems, such reactivation can lead to profound pathology. …
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The role of autonomic neurons in the pathegenesis of herpes simplex virus infection
… still remains unexplained. The mechanism of HSV latent infection in the peripheral nervous system (PNS) has been extensively investigated, especially with in sensory neurons. Another component of the peripheral nervous system (PNS), autonomic neurons, were also known to be infected with HSV …
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USING UNSUPERVISED LEARNING TECHNIQUES TO UNDERSTAND CD8+ T CELL DIFFERENTIATION DURING VIRAL INFECTION AND TUMOR DEVELOPMENT
… from those primed in acute or chronic viral infection, we adoptively transferred naive P14 CD8+ T cells into uninfected recipients, and compared their phenotype and function following infection with the Armstrong (acute) or Clone 13 (chronic) strains of LCMV, or MHV68 expressing the LCMV …
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Investigating and exploiting the latency-associated expression of the human cytomegalovirus gene US28 in early myeloid lineage cells.
… which establishes a lifelong persistent infection, underpinned by its ability to establish latent infection in early myeloid lineage cells, in the infected host. Although well controlled by a healthy immune system, HCMV causes pathological and life threatening disease in individuals with …
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Molecular analysis of herpes simplex virus type 1 latency in experimentally infected mice / Barry Slobedman.
The aims of this study are to determine whether latent HSV genomes are a result of viral DNA amplification in the PNS during the establishment phase and to investigate the relationship between HSV DNA copy number and viral transcriptional activity during latent infection of the PNS. In order to map …
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Characterization of CD8 T cell responses in Mycobacterium Tuberculosis infection
… CD8 T cell responses in individuals with latent Mycobacterium tuberculosis (MTB) infection (LTBI) and active TB disease, and further define MTB-specific CD8 T cell phenotypes associated with latent infection and active disease. Ex vivo IFN? Elispots and proliferation assays were used to …
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Characterisation of Novel Secreted Antiviral Factors to Human Cytomegalovirus
… other herpesviruses, HCMV readily establishes a latent infection that persists for the lifetime of the host and undergoes periodic lytic reactivation events. In healthy individuals, HCMV infection is typically asymptomatic, while in immunocompromised individuals, such as immunosuppressed …
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Systems analysis of the CD4 T cell response induced by the novel subunit tuberculosis vaccine, H1:IC31
… by vaccination and to examine the effects of latent M. tb infection on these responses. We had two broad objectives: Firstly, to determine the effects of latent M. tb infection on epitope recognition by mycobacteria-specific CD4 T cells and to design HLA class II tetramers for detection of …
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The incidence of tuberculosis in adolescents in the context of proposed TB vaccine trials
… TB epidemiology through a cohort study of TB infection and disease in adolescents in a high burden setting. Such data will support clinical trials of new TB vaccines in adolescents but the knowledge gained will also be of value for TB Control Programmes. [Methods] Adolescents aged 12-18 years …
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Temporal Regulation of LMP1 and Apoptosis Resistance After Primary EBV Infection
… human pathogen that establishes a lifelong latent infection in over ninety percent of all adult humans worldwide. While typically benign, EBV has been causally associated with a number of human malignancies in the settings of immune suppression, genetic, and/or environmental factors. While a …
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The role of latent membrane protein 2 in the pathogenesis of Epstein-Barr virus associated malignancy
Epstein-Barr virus (EBV) establishes a lifelong latent infection in host B cells and is associated with the development of various lymphoid and epithelial malignancies. Approximately half of Hodgkin's lymphomas (HL) are EBV positive where LMP2 is highly expressed. However, the contribution of LMP2 …
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The roles of human cytomegalovirus US27 gene product during virus infection
… is a widespread pathogen that causes lifelong latent infection. Successful persistence of HCMV in healthy individuals involves extensive manipulation of host cellular functions and immune responses. HCMV encodes four genes for putative G protein-coupled receptors (GPCRs): US27, US28, UL33, and …
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Development and Utilization of Novel Immunologic Reagents for Infectious Disease Studies in the Guinea Pig
Genital herpes disease caused by HSV-2 infections is a worldwide public health epidemic with a global prevalence estimated at 500 million. These individuals serve as a reservoir for transmission of the virus to naïve individuals resulting in a global increase of 26 million new infections per year. …
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The morphology, ecology and fungicidal tolerance of Botrytis cinerea isolates
… Side shoot stumps or scars were also liable to infection and the resulting lesions were more likely to become aggressive than lesions at leaf scars. Conidia were considered to be the major source of inoculum although lesions at leaf scars could take up to 61 days to develop after deleafing. This …
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Ubiquitin Targets and Molecular Mechanisms of Herpes Simplex Virus 1 Infection in Adult Sensory Neurons
… 50% of the human population. The symptoms of infection are herpetic lesions that frequently appear throughout a host's life in response to stress in the orofacial or genital region. As a pathogen, HSV-1 replicates rapidly in epithelial cells, but it is also capable of infecting neurons where …
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