Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 6 of 6 for “"late-stage functionalization"”.
-
Quinone-Catalyzed Amine α-C–H and α-C–C Functionalization
… introduction of amino groups. Emerging amine α-functionalization methodology enables the modification of existing amine-containing molecules at the α-amino position therefore providing new approaches to amine synthesis. Driven by our research interest in amine synthesis, we set out to explore …
-
Advances in Heterocyclic Synthesis through Ring Expansions and Flow Chemistry
… may prove critical when seeking to carry out late-stage functionalization of natural products as starting points in drug discovery. In this chapter, a stereoelectronically controlled ring expansion sequence towards selective and flexible access to complementary ring systems derived from …
-
Late-stage C(sp3)–H hydroxylation, amination, and methylation in nitrogen-containing molecules
… drugs, 84% contain at least one nitrogen atom. Functionalization of these molecules via transition metal catalysis faced substantial challenges, as the strongly Lewis basic nitrogen is prone to bind to the Lewis acidic metal center, thereby either shutting down the catalysis or limiting …
-
Accessing Challenging Fluorinated Motifs Using Photoredox Catalysis And Enabling Technologies
… reaction conditions and incompatibility with the late-stage functionalization of complex molecules. Photoredox catalysis invites a paradigm shift in the understanding of our capabilities to access diverse gem-difluoroalkene-containing small molecules because of its characteristically mild reaction …
-
Development of New Organic Photoredox Catalysis Driven by Visible Light
… Significantly, it is proved to be useful in a late-stage functionalization of complex molecules. Direct H/D exchange at formyl groups represents the most straightforward approach to C-1 deuterated aldehydes. Along this line, a new photoredox catalytic, visible-light mediated neutral radical …
-
Photochemical synthesis of dihydroquinolinones and their investigation toward macrocycle synthesis via ring expansion
… inexpensive thioxanthone photosensitisers.3 A related demethylation of amides was reported by Yi et al using a Cu catalyst and NFSI as an oxidant7 and in our attempt to use this procedure to produce the unprotected DHQ, we obtained the unsaturated quinolinone, instead. Quinolinones are important …