Global ETD Search
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Showing 1 to 4 of 4 for “"late sodium current"”.
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Human Nav1.5 F1486 deletion associated with long-QT syndrome leads to deficiency in inactivation and reduces lidocaine sensitivity
The cardiac voltage-gated sodium channel α subunit Nav1.5 generates the cardiac sodium current, which is essential for the initiation and propagation of the cardiac action potentials. Mutations of SCN5A, the gene that encodes Nav1.5, have been well documented to cause long-QT syndrome (LQTs) by …
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Augmentations vs. Restoration: A computational study of the effects of bacterial sodium channels on cardiac conduction.
… Augmentation of cardiomyocytes with exogenous sodium channels such as Nav1.4 or prokaryotic voltage-gated sodium channels, or BacNavs, have shown promise for potentially alleviating these arrhythmias. However, due to size constraints, only the BacNavs are available for the highest efficiency …
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Die Rolle der Kalzium-Calmodulin-abhängigen-Proteinkinase II δc (CaMKIIδc) bei der Radikal-vermittelten Zytotoxizität in isolierten ventrikulären Kaninchenmyozyten
Sauerstoffradikale sind an einer Reihe von pathologischen Vorgängen beteiligt, wie z.B. an Ischämie, der darauffolgenden Reperfusionsphase, an Alterungsprozessen sowie bei Herzinsu.zienz. Sie verursachen Zellschäden, haben allerdings auch wichtige Funktionen in Signaltransduktionswegen. …