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Showing 1 to 6 of 6 for “"late onset alzheimer's disease"”.
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Developing EasySci, a High-Throughput and Low-Cost Single-Cell Genomic Technique, to Study Aging and Alzheimer's Disease in Human and Mouse Brain
… of rare cell type contributions to aging and disease. Moreover, these methods often focus on the 3' end of genes. Without capturing the complete gene body coverage, these technologies have limited detection of specific isoforms. To address these limitations, we extensively optimized a …
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The Role of Apolipoprotein E Concentration and Isoform in Amyloid-beta Metabolism In Vivo
Alzheimer's disease is a progressive, neurodegenerative disease characterized by several pathological lesions, one of which is the accumulation of the amyloid-β: Aβ) peptide into extracellular amyloid plaques. Several autosomal dominant mutations have been shown to cause familial forms of …
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The Effect of Chronic Hypertension on Neuropathology in the TGSWDI Mouse Model of Alzheimer's Disease
… such as hypertension, diabetes and stroke, with Alzheimer's disease. Hypertension, specifically, is an important modifiable risk factor for late onset Alzheimer's disease. Despite the abundance of clinical data connecting these conditions, animal studies investigating the connection between the …
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Development of Graphical Models and Statistical Physics Motivated Approaches to Genomic Investigations
<p>Identifying genes involved in disease pathology has been a goal of genomic research since the early days of the field. However, as technology improves and the body of research grows, we are faced with more questions than answers. Among these is the pressing matter of our incomplete understanding …
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Ectodomain Mutations Alter the Proteolysis of the Amyloid-β Precursor Protein (APP)
<p>Alzheimer’s disease (AD) is the most common form of dementia, affecting over 5 million Americans. In AD patients there is a buildup of amyloid plaque in the brain, which contributes to AD symptoms. The main component of plaques is Amyloid-β (Aβ), a 40-42 length peptide formed from Amyloid-β …
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Apolipoprotein E4 and SirT1 Interaction in Alzheimer’s Disease
<p>Alzheimer’s disease (AD) is a neurodegenerative disorder whose exact cause(s) are still unknown. Εpsilon 4, an allele of apolipoprotein E (ApoE4), is currently the most important risk factor for Alzheimer’s disease. Individuals that inherit two copies of the ApoE ε4 allele have an approximately …