Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"lasso peptides"”.
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Investigations into the molecular basis of enzyme-catalyzed reactions in natural product biosynthesis
… synthesized and post-translationally modified peptides (RiPPs). The chemical modifications found in these peptide natural products further distinguish each them into specific types. The borosins constitute a class of RiPPs that are characterized by a cyclized N-C structure with methylations on …
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Genomics as a tool for natural product structure elucidation
… of streptomonomicin (STM), an antibiotic lasso peptide from Streptomonospora alba, and report the genome for its producing organism. STM-resistant clones of Bacillus anthracis harbor mutations to walR, the gene encoding a response regulator for the only known widely-distributed and …
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Biomolecular NMR studies of the structure and biosynthesis of RiPP natural products
… and Posttranslationally modified Peptides (RiPPs) are a particularly intriguing class. These compounds begin as a genetically encoded precursor, which is translated into a short (~50) residue peptide. This precursor peptide is then modified by genetically co-located enzymes to …
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Practical applications of genomics to natural product discovery and biosynthesis
… product gene clusters, and initially focused on lasso peptides, where our application of hidden Markov models, heuristic and sequence motif analysis, and machine learning revealed new scaffolds. This genome-mining approach enabled by RODEO prioritized strains with unique biosynthetic clusters and …
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Biosynthetic and Chemical Investigation of Lipid II-Binding Antimicrobials.
… natural products within the lasso peptide subfamily. This work led to the discovery of a novel class I lasso peptide, arcumycin, and we validated a conserved mechanism of action for Actinobacteria-produced lasso peptides in targeting lipid II biosynthesis. Our last project …
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Discovery and characterization of ribosomally synthesized and post-translationally modified peptide natural products
… potency. The citrulassin sub-family of lasso peptides contain a citrulline post-translational modification which inspired reactivity-based screening for additional citrullinated natural products from bacteria. While ubiquitous in eukaryotes, deamination in bacteria is poorly …
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Elucidation and control of substrate recognition during RiPP biosynthesis
… synthesized and posttranslationally modified peptides (RiPPs) are a rapidly growing class of natural products. RiPP precursor peptides can undergo extensive enzymatic tailoring to yield structurally and functionally diverse products. Cyclodehydratases are a type of RiPP modifying enzyme that …
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Peptides and proteins with unusual structure: From biophysical measurement to control of structure
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2025-12-01
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Genomics-Guided Discovery and Characterization of Ancillary RiPP Modifications
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2024-08-01