Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 31 for “"large-scale synthesis"”.
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Part I: Mechanistic Insight in Alkyl-Alkyl and Aryl-Aryl Negishi Cross-Coupling Part II: Large Scale Synthesis of NHC Precursors: 2,6-DI(3-Pentyl) Aniline and 2,6-DI (4-Heptyl) Aniline
… the results of optimization for the multi-gram synthesis of 2,6-disubstituted anilines is discussed.
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Tailored Optical Properties on the Macroscale by Template-Assisted Self-Assembly of Plasmonic Nanoparticles
… effective optical properties on the macroscale via controlled hierarchical surface-assembly of plasmonic nanoparticles. The fundamental concept pursued in this thesis can be divided into three sub-goals that are addressed in individual publications: (I) controlled large-scale synthesis of …
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Part I: The Large-Scale Synthesis of Hyaluronan Disaccharides Utilizing a Mild Cleavage of 2-Amino-2-Deoxy-D-Glucoside Methoxycarbonyl Derivatives With Methyltrichlorosilane and the Application for the Synthesis of Carbohydrate Polymers. Part II: The Synthesis of Models for Use in Studying the Solution Behavior of Carbohydrates in a Hydrophobic Environment
A better understanding of the solution behavior of carbohydrates, specifically the investigation into their hydrophobicity, would allow for a better understanding of the carbohydrate interactions occurring at a cellular level. The syntheses of model compounds incorporating a hydrophobic pyrene …
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Structure-property engineering and device fabrication of conjugated polymers by chemical vapor deposition
… and device applications. High quality and large-scale synthesis of soft materials are the foundation of soft electronics. CVD approach has proved to be a low-cost and scalable technique to synthesize a wide variety of soft materials with desired properties. The first part (Chapter 2) will …
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Towards the total synthesis of gambieric acid A
… this thesis is to show the progress towards the synthesis of F–J ring system of gambieric acid A. First, the large scale synthesis of I–G ring fragment using the two directional ring closing metathesis developed in the laboratory is described including the improvements made to the previous …
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Synthesis and biological evaluation of functionalized benzoxaboroles as potential antimicrobial agents
… the existing literature methodologies for the synthesis of highly functionalized benzoboroxoles are difficult and often are not suitable for large scale synthesis. We have been working on the development of novel synthetic methodologies for the synthesis of functionalized benzoxaboroles as …
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Borox catalysis : a new frontier in chiral Bronsted acid catalysis derived from chiral borate anions
… of the new chiral Brønsted acid catalysts, large-scale synthesis, novel reaction methodologies and understanding their mechanisms by experimental/computational analysis. In due course of time, a pool of unprecedented chiral Brønsted acid catalysts known to be "BOROX" catalysts, were prepared …
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Transition metal-facilitated C-C and C-F bond forming
… of the process is further illustrated by a large scale synthesis with extremely low catalyst loading as well as the late stage modification of several pharmaceuticals. Chapter 2. Copper-Catalyzed Enantioselective Addition of Styrene-Derived Nucleophiles to Imines We describe the catalytic …
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The utilisation of Fmoc solid phase chemistry as a novel approach to the generation of duocarmycin analogues
… thesis describes the conception and multi-gram synthesis of a duocarmycin SA alkylation subunit suitably substituted to serve as a building block for Fmoc based solid phase synthesis and initial investigations into its application. Chapter two describes the pilot and subsequent large scale …
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Efeito do relaxamento induzido por diosgenina em artéria mesentérica de rato após administração de 17-β estradiol.
… to estradiol and phytoestrogen is used for large scale synthesis of various steroid hormones. The purpose of this study was to investigate whether the relaxing effect induced by diosgenin, would be altered by estradiol and verify wh ether diosgenin and estradiol would modulate the basal …
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Scalable Synthesis and Separation Performance of Covalent Organic Framework and Contorted Polyamide Membranes
… are energy and chemical intensive with large environmental footprints. Membrane separation processes are an environmentally friendly alternative to conventional processes due to their higher energy efficiency and precise separation capability. Nanofiltration (NF) is used to separate …
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Robust Parameter Design for Automatically Controlled Systems and Nanostructure Synthesis
… dynamic systems with automatic control and for synthesis of nanostructures. In many automatically controlled dynamic processes, the optimal feedback control law depends on the parameter design solution and vice versa and therefore an integrated approach is necessary. A parameter design …
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Surface Functionalized Water-Dispersible Magnetite Nanoparticles: Preparation, Characterization and the Studies of Their Bioapplications
<p>Iron oxide magnetic nanoparticle synthesis and their surface functionalization hold a crucial position in the design and fabrication of functional materials for a variety of biomedical applications. Non-uniform nanoparticles with poor crystallinity, prepared by conventional methods, have only …
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Graphene Decorated Substrates and Their Interfacial Characteristics
… face the scientific community: (i) Expanding the scale of synthesis and (ii) Integration of different carbon structures for improved functionality. While significant advancements have been made in large-scale synthesis, room for improvement remains. As the scale of production increases, issues …
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Scalable Synthesis and Separation Performance of Covalent Organic Framework and Contorted Polyamide Membranes
… are energy and chemical intensive with large environmental footprints. Membrane separation processes are an environmentally friendly alternative to conventional processes due to their higher energy efficiency and precise separation capability. Nanofiltration (NF) is used to separate …
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Production of a functional human milk oligosaccharide, 2'-fucosyllactose, using microbial cell factories
… expensive, and thus impractical for a large-scale synthesis. In my research study, an alternative route to produce 2-FL using a microbial cell factory was devised. First, E. coli, as a host strain to produce 2-FL, was engineered to overexpress genes in the metabolic pathway of …
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Acenaphthylene Based CP-PAH Materials for Organic Semiconductors
… as low cost, flexibility, and applicability for large area production. Because of the possible commercialization of electronic products based on organic conducting materials, it is important to develop a variety of organic semiconductors (OSCs) that are categorized as hole transporting (p-type), …
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Robust Processes for Polymer Modification and Pharmaceutical Synthesis
… This method has been demonstrated on gram scale. Chapter 2: Large-Scale Synthesis of Molnupiravir from Cytidine Molnupiravir (Lagevrio®, MK-4482, EIDD-2801) is an orally bioavailable medication for COVID-19. We report the development of a supply-centered and chromatography- free synthesis …
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Synthesis And Characterization Of Size Controlled Transitionmetal Phosphide Nanoparticles And Their Hydrodesulfurization Catalytic Activity
… based arrested precipitation method; (2) develop large scale synthesis of mesoporous silica encapsulated nanoparticles (Ni<sup>2</sup>P and Pd<sup>5</sup>P<sup>2</sup>) with controlled loading to prevent sintering at high temperatures; (3) establish the structure activity relationship of …
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Development of transition metal-catalyzed C-S and C-C cross-coupling reactions
… developed new cross-coupling protocols for the synthesis of vinyl sulfides, benzothiazoles and benzoxazoles, using transition-metal-based catalysis. Furthermore, the mechanism of these cross-coupling reactions has also been investigated. Although numerous methods have been developed for the …
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