Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 59 for “"large subunit"”.
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A Functional Analysis of the RNA Polymerase II Large Subunit C-Terminal Domain
Doktorarbeit zur Untersuchung der grossen Untereinheit des RNA polymerase II
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Generic concepts in the Crepidotaceae as inferred from nuclear large subunit ribosomal DNA sequences, morphology, and basidiospore dormancy patterns
… Crepidotaceae were investigated using nuclear large subunit ribosomal DNA (LSU rDNA) sequences. Parsimony analysis of the molecular data supports the Singer classification of Crepidotus, Melanomphalia, and Simocybe as a single monophyletic unit within the Agaricales. The affinities of the genus …
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Structural Studies of the Nucleolar Stages of Ribosome Biogenesis in Yeast
… Ribosomes are heterodimers made up of a small subunit (SSU, 40S) and a large subunit (LSU, 60S). At the interface of these subunits, the mRNA is decoded by the small subunit and peptide bond formation is catalyzed by the rRNA of the large subunit. The cell therefore requires the timely and …
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The Accumulation Kinetics of The Small and Large Subunits of Ribulose 1,5-Bisphosphate Carboxylase During Chloroplast Development in Euglena Gracilis
… carboxylase (RuBPCase) is composed of two subunits, a large subunit which is encoded and synthesized in the chloroplast, and a small subunit which is encoded in the nucleus and synthesized in the cytoplasm. By determining the accumulation kinetics of the two subunits during chloroplast …
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Structure-Based Drug Design Against a Biosecurity Pathogen
… triggers conversion to the metabolically active large cell variant. Disease begins in an acute phase, with flu-like symptoms and some cases develop into a chronic infection, the debilitating and potentially fatal form of Q-fever. C. burnetii is sensitive to the antibiotic doxycycline, which can …
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From ribosomal rotation to autism and cancer
… reading frame maintenance, and gene expression. Large-scale chemical modification analyses of rRNA of the mutant ribosomes identified networks of near-, medium-, and long-range allosteric interactions involved in coordinating intersubunit rotation. These allosteric pathways map from L10 in the …
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A Molecular Phylogeny of the Calypterate Diptera
A region of the large subunit rRNA (28s) was developed as a tool for eukaryotic family level phylogeny. This region was sequenced for 20 Diptera and analyzed using the computer package PAUP (Phylogenetic Analysis Using Parsimony), created by David Swofford. The trees were compared to previous …
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Making Ribosomes: Biochemical and Structural Studies of Early Ribosome Biogenesis in Yeast
… proteins, asymmetrically divided in a small and large subunit. In a growing yeast cell, more than 2000 ribosomes are assembled every minute. The ribosome is assembled through a highly complex process involving more than 200 trans-acting factors. Ribosome assembly begins in the nucleolus where RNA …
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A Molecular Phylogenetic Assessment of the North American Lichen Tiger Moths (Lepidoptera; Erebidae; Arctiinae; Lithosiini) with Life History Observations and a Description of a New Species from Central Arizona
… description. As such, they represent one of the larger radiations among the ditrysian Lepidoptera. Yet the taxonomy of the group remains uncertain, their life histories largely unknown and at least 25% of their biodiversity undescribed. We inferred the phylogeny of North American lithosiines …
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Modeling The Active Site Of [NiFe]-Hydrogenase
… a heterodimeric enzyme, and it is composed of a large subunit and a small subunit, inside the large subunit is buried the active site deep within the protein, while the small subunit contains a series of [Fe-S] clusters that controls the electron transfer system of the enzyme. The active site is …
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Development and validation of PCR-RFLP assay for identification of Gambierdiscus species in the Greater Caribbean region
… targets the D1-D2 hypervariable regions of the large subunit ribosomal RNA gene and uses a single restriction enzyme (BsrI). This method produces distinct RFLP banding patterns for the six species of Gambierdiscus reported from the Gulf of Mexico and Caribbean Sea, and it distinguishes them from …
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Identification of morphologically similar species of necrophagous flies (diptera: calliphoridae) in Oklahoma : reliability and application of techniques in a forensic setting.
… analyses. A 330 basepair amplicon within the 28S large subunit of ribosomal DNA was obtained for thirty-five specimens. Molecular phylogenetic results were compared to morphological identifications in order to ascertain the reliability of the respective laboratory techniques. Morphological and …
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Molecular phylogenetics of the Metazoan clade Lophotrochozoa
… using sequences of the nuclear ribosomal large-subunit RNA gene (LSD rDNA). Results presented provide the first molecular evidence for a close relationship between the Scaphopoda and Cephalopoda. Phylogenetic trees with this topology were found to have likelihood scores significantly …
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p53 in a Genetic Model: Illuminating Adaptive Radiation Responses
… Thus far, I uncovered ribonucleotide reductase large subunit (RnrL) as a novel Dmp53 target that is necessary for induction of caspase activation. Taken together, my study supports the notion that core ancestral functions of the p53 gene family are intimately coupled to cell death and possibly …
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cDNA Cloning and Gene Characterization of Large and Small Subunits of Ribonucleotide Reductase in Soybean
… E. coli and in animals consists of two identical large and two identical small subunits. Until recently, little was known about RNR in plants. For cloning RNR cDNA in plants, soybean (Glycine max) cDNAs were amplified with highly degenerate primers and the Rapid Amplification of cDNA Ends …
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Molecular phylogeny of Melanospora and Diaporthales, and population genetics of dogwood anthracnose fungus
… on DNA sequences of nuclear encoded small and large subunit RNA genes (SSU and LSU nrDNA) and deduced amino acid sequences of a subunit of RNA polymerase II gene (RPB2) indicated that five genera previously considered in Ceratostomataceae of Sordariales were related to Hypocreales. Melanospora …
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Resistance to protein synthesis inhibitors in Coprinus cinereus
… to Identify the particular cytoplasmic ribosomal subunit which conferred cycloheximide-resistance. Analysis of cytoplasmic ribosomal proteins by two-dimensional gel electrophoresis did not reveaú. any difference between the small subunit proteins of CY 8 and CY 8.2. There were a considerable …
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Molecular and Biochemical Analyses of a Three-Subunit Euryarchaeal Clamp Loader Complex
… clamp loader comprises two similar small subunits (MacRFCS1 and MacRFCS2) and one large subunit (MacRFCL). Since the simplest RFC is made up of two different subunits and the most complex form is made up of five different subunits, the MacRFC may represent a critical link in the evolution …
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Structural studies of trans-translation
… of both RNA and protein, and are composed of two subunits, each with a separate function. The small subunit reads the mRNA message, directing the large subunit to synthesize a sequence of amino acids to form a protein. In many cases, mRNA may be damaged or truncated in such a way that ribosomes …
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Structural studies of the mitochondrial ribosome and co-translational insertion of membrane proteins
… phosphorylation. The enzymes that make up the subunits of oxidative phosphorylation in humans and yeast are encoded by both nuclear DNA and in mitochondrial DNA. As such the mitochondrion has retained its own translational system to include mitochondrial ribosomes (mitoribosome) to translate …
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