Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"large intestines"”.
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Magnitude and site of absorption of magneseium and other minerals in ruminants fed different levels of potassium
… level was increased from 1.2 to 2.4%. A further large decrease in absorption occurred when the potassium level was increased from 2.4 to 4.8%. Serum magnesium was depressed when higher levels of potassium were fed. Potassium absorption was not affected by level of dietary magnesium, but increased …
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Host-Microbiota Interactions
… we found that the interaction network in the large intestines is sparse compared to the network in the small intestines. We postulate that the sparse interaction is due to a specialized role of microbiota in the large intestines and may explain the associations between altered microbiota and …
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Impacts of mucins on microbial physiology and interactions
… inhabit mucosal surfaces, with most found in the large intestines, but many also dwell in the respiratory and urogenital tracts. Despite the enormous microbial population inhabiting the body, some of which are opportunistic pathogens, most people harbor these organisms without showing any signs of …
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Effects of feeding lasalocid and monensin upon mineral status of steers, and partial absorption and renal handling of minerals in sheep
… were fed. Magnesium flow through the small and large intestines was decreased by lasalocid and monensin. Effects of lasalocid and monensin differed for metabolism, digestive tract flow and (or) partial absorption of Ca, P, Cu, Fe and Zn. Twelve ewe lambs were used in a renal clearance …
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The intrinsic role of SOCS1 in intestinal epithelial cells
… gene deletion in IEC lineages of the small and large intestines. Analysis of this Socs1ΔIEC mouse model suggests that lethal ulcerative colitis might be driven by Paneth and goblet cell defects, like those seen in inflammatory bowel disease patients and mouse models with defective genes …
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Modeling Sporadic Tumor Formation Driven By Telomere Dysfunction In The Gastrointestinal Tract
… of invasive adenocarcinomas in the small and large intestines. The tumors formed with long latency, low multiplicity and had complex genomes due to chromosomal instability, features similar to those seen in sporadic human colorectal cancers. Taken together, we have developed a novel mouse …
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Combining population-scale single-cell transcriptomics with germline genetics to understand the biology of inflammatory bowel diseases
… commonly afflicted regions - the small and large intestines. Thusfar the efforts to align these two fields have been minimal despite the large benefit to doing so. In this thesis I explored the genes, cell types and pathways driving inflammatory bowel diseases with IBD relevant single-cell …
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Characterisation of L-cell secretory mechanisms and colonic enteroendocrine cell subpopulations
… so-called L-cells found in both the small and large intestines. GLP-1 exerts an anorexigenic effect and together with glucose- dependent insulinotropic polypeptide (GIP), restores postprandial normoglycaemia through the incretin effect. These effects are exploited by GLP-1 analogues in the …
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Microencapsulation of tributyrin to improve sensory qualities and intestinal delivery
… deliver and produce butyrate in the small and large intestines. Results from the descriptive analysis (DA) test conducted using GCT OD in apple sauce, infant formula, and crackers, revealed that GCT OD behaved differently in each system due to the matricies physical properties. Combined common …
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Ethanol-induced formation of colorectal tumours and precursors in a mouse model of Lynch syndrome
… family of enzymes, particularly Aldh1b1 in the intestines. Acetaldehyde is very reactive and may cause a range of DNA lesions. However, DNA repair pathways responsible for correcting such lesions remain unknown. It was hypothesized that MMR plays a role in protecting intestinal cells from …
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Notch activation and clone fate in intestinal homeostasis and inflammation
The Notch signalling pathway is a highly conserved pathway that has important and often differing roles and functions depending on the tissue. In the intestinal epithelium Notch signals are important for determining cell fate between the absorptive and secretory lineage and regulating the …