Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"lapachone"”.
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Beta-Lapachone Nanotherapeutics for Lung Cancer Therapy
… increasing specificity, and in turn, efficacy. β-Lapachone (β-lap) is a novel anticancer drug whose mechanism of action relies on its bioactivation by the enzyme NAD(P)H:quinone oxidoreductase-1, NQO1, found overexpressed in NSCLC. While promising, its low water solubility limits its clinical …
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Total synthesis of (S)-4-hydroxy-[a]-Lapachone
(S)-4-Hydroxy-a-lapachone has been prepared for the first time. The commercially available compound 2-acetyl-1-naphthol was used as the starting material. The synthesis involved methylation, followed by Baeyer-Villiger oxidation, and hydrolysis of the acetate to give 1-methoxy-2-naphthol. After …
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The Identification and Targeting of Altered NAD+ Metabolism in Glioblastoma
… sensitive to the NQO1-bioactivatable compound β-lapachone. β-lapachone induced acute DNA damage and NAD+ depletion. However, GBM cells may evade this depletion through activation of NAD+ biosynthesis pathways. We performed additional studies and demonstrated GBM cells predominantly maintain NAD+ …
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NQO1-Bioactivatable Drugs at the Interface of Cancer Metabolism and the DNA Damage Response
… a unique class of quinones, such as ß-lapachone (ß-lap) and deoxyniboqunine (DNQ), through a futile redox cycle to generate massive levels of superoxide radical to induce extensive DNA oxidative base damage, single strand breaks and poly(ADP-ribose) polymerase 1 (PARP1)-driven depletion …
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Improving the Efficacy and Expanding the Application of NQO1-Bioactivated Therapeutics
… (NQO1)-bioactivated drugs, such as ß-lapachone (ß-lap), are powerful therapeutics for tumor-specific therapy. They react with NQO1, which is highly overexpressed in most solid tumors, to cause a futile redox cycle that results in devastating oxidative DNA damage and energy depletion in …
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The Physiological Effects of CD38 in Prostate Cancer: A multifunctional NAD'ase capable of regulating cell metabolism, gene expression, and therapeutic response
… in calcium localization confer protection from β-lapachone, an ortho naphthoquinone that is cytotoxic to cells when activated by NAD(P)H quinone oxidoreductase 1 (NQO1). Cumulatively, these data establish a novel connection between CD38, modulation of NAD+, and prostate tumor cell metabolism, …
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SÍNTESE DE NOVOS DERIVADOS DE LAPACHONAS E NOR-LAPACHONAS: VEREDAS À ATIVIDADE FARMACOLÓGICA
… starting from the key intermediate 3-bromo-nor-β-lapachone (37). A great number of possibilities was opened with the obtaining the naphthoquinones 3-azido-2,2-dimethyl-2,3-dihydro-naphtho[1,2- b]furan-4,5-dione (79), 4-azido-2,2-dimethyl-3,4-dihydro-2H-benzo[g]chromene-5,10- dione (86) and …