Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 27 for “"laminitis"”.
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METABOLIC CHARACTERISTICS AND SUSCEPTIBILITY TO LAMINITIS IN MORGAN AND THOROUGHBRED HORSES
<p>Laminitis, an inflammation of the lamina in the equine foot, is one of the least understood of the common equine diseases and is considered to be one of the greatest problems facing the horse owner and veterinarian today. The incidence of, and breed susceptibility to, this disease has never been …
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Identification of genetic loci underlying equine metabolic syndrome and laminitis risk
Laminitis is a painful, debilitating disease of the hoof, often resulting in these horses being humanely euthanized due to uncontrolled pain. The most commonly cited cause of this life-threatening disease is a clustering of clinical signs resulting from a metabolically efficient phenotype, termed …
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Matrix metalloproteinases in the equine systemic inflammatory response: implications for equine laminitis
Laminitis is a crippling and often life-threatening disease of the equine foot. Soft tissue damage characteristic of this disease has been associated with increased MMP activity. Therefore, it seems likely that MMPIs could be potential therapeutic agents for laminitis. Further characterization of …
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Equine obesity and its role in insulin resistance, inflammation and risk for laminitis
… resistance, inflammatory state and risk for laminitis, and the effectiveness of exercise training to reduce obesity and insulin resistance in equids. Practical methods of assessing adiposity were developed and verified, including a condition scoring system for neck crest adiposity and …
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Effects of Early Spring Growth Annual Ryegrass Pasture Consumption on Parameters Associated with Laminitis in Horses
Ten adult Quarter Horses (5 mares and 5 geldings) were placed in dry lot for 90 days and allowed free choice access to a diet consisting of average quality orchard grass hay, salt and water. The horses were then allowed free choice access to early-growth annual ryegrass pasture, salt and water for …
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The equine metabolic syndrome: studies on the pathophysiology of obesity, insulin resistance, and laminitis in equids
… has been associated with predisposition to laminitis in horses and ponies; in humans, adipose tissue (AT) inflammation is associated with IR. The first series of studies reported here characterized inflammatory gene expression and leukocyte infiltration in several AT depots of …
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Investigation of a Model for the Study of Digital Perfusion in Equine Laminitis Using an Extract of Black Walnut (Juglans Nigra)
… the acute phase and in the convalescent phase of laminitis induced by an aqueous extract of BW.
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Genetic analysis of hoof traits
Heritabilities of heel erosion and laminitis were more than 10% and improvement by traditional quantitative methods should be possible. Ranges of incidences of hoof traits varied from.6% to 2.1% (interdigital hyperplasia) to higher than 50% (heel erosion) in reference herds. Means of fifteen hoof …
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Glucose disposal and insulin sensitivity at rest and during exercise in trained horses adapted to different dietary energy sources and in association with laminitis in ponies
… between ponies predisposed to pasture laminitis (PL) from ponies not predisposed (NL). A subset of 14 ponies (7 PL, 7 NL) also underwent the FSIGT for minimal model analysis. Ponies predisposed to laminitis were found to have lower insulin sensitivity (P < 0.007) and higher insulin …
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Metabolic alterations to sudden introduction of high carbohydrate diets in ruminating dairy bull calves
… whether it is possible to create acute laminitis in young ruminating calves by feeding high carbohydrate diets. Three experiments were performed. In the first, 16 calves, 17 wk of age, were fed one of four diets (4 replications) that contained either 71 or 81% of TDN and either 15 or 20% …
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A pharmacokinetic and pharmacodynamic study of pioglitazone in a model of induced insulin resistance in normal horses
… insulin resistance, and an increased risk of laminitis. Reducing insulin resistance may decrease the incidence of laminitis in horses with EMS. Pioglitazone, a thiazolidinedione class of anti-diabetic drug, has proven efficacy in humans with type 2 diabetes, a syndrome of insulin resistance …
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Design of a Robotic Equine Forelimb for Testing Load-Bearing Rehabilitative Devices
… in angular limb deformities, lax tendons, laminitis, and similar problems. These problems could possibly be avoided through a load-bearing device that would relieve the additional weight from the foal's limbs. In order to allow for in-vitro testing of such a load-bearing device, this thesis …
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The Suitability of Native Warm-Season Grasses for Equine
… pose a risk for horses prone to obesity and laminitis. Native warm-season grasses (NWSG) have lower digestible energy and NSC levels that may be more suitable for horses susceptible to laminitis. The overall objectives of this research were to 1) assess voluntary intake, toxicological …
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Thyroid Status in Exercising Horses and Laminitic Ponies
… laminitic (NL; n = 72) and evaluated for current laminitis in May (CL; n = 13). Decreased concentrations of TT4 and FT4 were found in PL ponies when compared to NL ponies in March (P = 0.018, 0.020) and May (P = 0.018, 0.001). However, TT4 and FT4 concentrations in CL ponies were not different …
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Influence of body weight gain on insulin regulation, adipose tissue inflammation and lipid metabolism in equines
… such as insulin dysregulation (ID), laminitis and hperlipaemia are increasing health issues in equines. In human medicine obesity is linked with a systemic inflammation deriving from adipose tissue (AT). Especially abdominal AT produces inflammatory cytokines and is therefore a risk …
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Circadian and Seasonal Variation in Pasture Nonstructural Carbohydrates and the Physiological Response of Grazing Horses
… of digestive and metabolic disorders, such as laminitis. A series of five studies at Virginia Tech's M.A.R.E. Center in April, May, August, and October 2005, and January 2006, examined circadian and seasonal variability in forage NSC content and metabolic and digestive variables in horses over …
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Serum concentrations of lidocaine and its metabolites after prolonged infusion in healthy horses
… in pain management, such as in cases of severe laminitis, and are often used for prolonged durations. To date only limited time/concentration relationships of lidocaine administered as a short term (24hours) CRI to horses are reported. This study examined the time/concentration profile of …
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Trends in Equine Nutrition and the Effects of a Hindgut Buffer Product in Overconditioned Horses
… fatal in horses, including insulin resistance, laminitis, and equine metabolic syndrome (EMS). Objectives of this research included first, characterization of nutrition-related management practices of hunter/jumper show industry via a voluntary survey; second, evaluating the Body Condition Index …
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Pharmacokinetics and Safety of Acetaminophen in Adult Horses
… to be efficacious as an adjunct treatment for laminitis in one pony, and was an effective analgesic agent when combined with NSAIDs in a model of inducible foot pain. However, no studies have been performed to validate a dose-response curve in horses. A study recently completed by our group …
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Physiological response of grazing horses to seasonal fluctuations in pasture nonstructural carbohydrates
… and digestive diseases, including colic and laminitis. A yearlong grazing study was conducted at the Virginia Tech Middleburg Agricultural Research and Extension Center from October 2016 through September 2017 to investigate fluctuations in pasture NSC concentrations as well as the metabolic …
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