Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"laminins"”.
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Role of Laminins in the Development of the Peripheral Nervous System
<p>To investigate the function of laminins in peripheral nerve development, the laminin γ1 gene was specifically disrupted in Schwann cells. Disruption of laminin γ1 gene expression resulted in depletion of all other laminin chains known to be expressed in Schwann cells. Schwann cells lacking …
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Laminins in blood vessel development and disease -functional aspects in angiogenesis, atherosclerosis, and muscular dystrophy
… Vital components of all basement membranes are laminins, heterotrimeric combinations of different laminin chain isoforms. The different laminins and their subunits largely have a developmental and tissue specific distribution. To determine the function of laminin isoforms in pathological …
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Role of Laminin gamma 1 in Cortical Development
<p>Laminins are a major component of basement membranes, including those in the central nervous system (CNS). To explore the role of laminin γ1, a subunit common to all laminins found within the CNS, we developed a murine model in which laminin γ1 is conditionally disrupted in the nervous system. …
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Gene expression studies of pregastrulation development: the basement membrane is essential for cell differentiation
… in development, tissue homeostasis and disease. Laminins, a major BM component, are multidomain proteins, consisting of three polypeptide chains (α, β and γ). During pregastrulation development, stem cells convert and epithelial tissues are formed. This process is faithfully mimicked in vitro by …
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Developing a clinically applicable hydrogel for the treatment of liver disease
… proteins. Next, the conjugation of selected laminins to serum-derived proteins led to the discovery of a novel albumin-based hydrogel with potential in bone engineering and a fibrin-based hydrogel (termed "Alphagel") with a strong potential for clinical translation. Alphagel was shown to …
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The role of the tumour microenvironment components in cancer cell behaviour and drug response
… biopsies showed that collagens, fibronectin, and laminins were overexpressed in tumour tissue compared with adjacent normal tissues. The culture of cancer cells on decellularised ECMs reduced the effect of drugs on cancer cells compared to those plated on plastic (control). The reduction of the …
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Hyperosmolality effects on growth and morphology of CHO cells
… abundant ECM components, such as collagens, laminins, and nidogens, are significantly downregulated in feed cells. However, although some proteins are markedly altered in their abundance, the overall protein composition of the cell seems to be retained to a large extent, i.e., the …
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Investigating the control of epithelial polarisation in human kidney organoids
… integrins and their ECM ligands, including laminins, another known polarising interaction, and further characterised the ECM niche within which nephron progenitors and their surrounding stroma develop. Finally, in chapter 3, I used a CRISPR/Cas9-based genetic intervention system to …