Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"laminin-111"”.
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The role of recombinant human laminin-111 in adhesion-signaling and glycosylation in laminin-⍺2 deficient muscle
… by mutations in LAMA2 which encodes for the laminin-α2 protein. Loss of laminin-α2 results in the absence of laminin-211/221, an extracellular matrix protein essential for anchoring skeletal muscle cells to the basal lamina. LAMA2-CMD patients experience profound muscle weakness from birth, …
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Analyzing Interactions Between Cells And Extracellular Matrix By Atomic Force Microscopy
… (90 minutes) to ECM proteins collagen-I and laminin-111. Interestingly, early adhesion (< 2 minutes) to laminin-111, was integrin-independent and instead mediated by carbohydrate interactions and galectins. In contrast, early adhesion to collagen-I was exclusively mediated by integrins. …
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α7β1 integrin regulation of skeletal muscle growth in response to mechanical stimulation
… α7 integrin overexpression or integrin ligand (laminin-111, LM-111) binding can improve the anabolic response to loading in aged mice. Aim 1 used microarray analysis using RNA extracted from skeletal muscle of wild type (WT) or transgenic mice (MCK:α7BX2 integrin; α7Tg), under sedentary …
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Development of novel in vitro platforms to model the lung
… a screening of ECM hydrogels, we identified laminin-111 as a key ECM molecule that supports the culture of AT2 cells and formation of organoids known as alveolospheres. We further showed that laminin-111 can be used by itself or in combination with other ECM proteins such as fibrin or …
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Gene Expression in mESC Deficient in FGFR Signalling and the Identification of the Novel Gene Ened
… signalling, the mutant EBs failed to synthesize laminin-111 and collagen type IV, the main building blocks of the basement membrane (BM) protein network. The aim of this thesis was to elucidate the molecular and biological changes occurring due to impaired FGF/FGFR signalling in differentiating …
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Development of novel strategies to improve skeletal muscle repair and adaptation following eccentric exercise
… gene expression is enhanced in the presence of laminin, an important component of the basal lamina that provides the microenvironment for muscle stem cells. Thus, the purpose of this study was to determine the extent to which mMSC and laminin-111 (LM-111) supplementation can enhance muscle …