Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 146 for “"laminin"”.
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The role of recombinant human laminin-111 in adhesion-signaling and glycosylation in laminin-⍺2 deficient muscle
… by mutations in LAMA2 which encodes for the laminin-α2 protein. Loss of laminin-α2 results in the absence of laminin-211/221, an extracellular matrix protein essential for anchoring skeletal muscle cells to the basal lamina. LAMA2-CMD patients experience profound muscle weakness from birth, …
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The platelet laminin receptor : discovery of a 67kDA receptor for laminin on the membranes of human platelets : characterisation and isolation
… platelets to the basement membrane glycoprotein, laminin, has identified the Ic/IIa integrin c01aplex (CD49f/CD29), also known as VLA-6, as the receptor. There exists however, another protein with a molecular weight of 67kDa, that mediates this function on other cells. It is abundantly expressed …
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Role of Laminin gamma 1 in Cortical Development
<p>Laminins are a major component of basement membranes, including those in the central nervous system (CNS). To explore the role of laminin γ1, a subunit common to all laminins found within the CNS, we developed a murine model in which laminin γ1 is conditionally disrupted in the nervous system. …
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Cloning, Characterization, and Functional Study of Laminin a Chain in Hydra
… a hydra cDNA library was accomplished by using a laminin A chain sequence obtained from polymerase chain reaction as a probe. A clone, 1am A1, was sequenced and characterized in this project. In situ hybridization studies indicated that the laminin A chain messenger RNA is located in the endoderm. …
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Nephrotic Syndrome and Glomerular Basement Membrane: Genetic Defect of the Laminin α5 Chain
… cell-matrix interactions. <br></br><br></br> The laminin α5 chain is a 404 kDa protein essential for embryonic development and, in association with laminin β2 and laminin γ1, it is a major component of the glomerular basement membrane. Mutations in <i>LAMB2</i> are associated with Pierson’s …
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The role of the 37-kDa/67-kDa laminin receptor in the cellular metabolism of the prion protein
… wird die Interaktion des 37-kDa/67-kDa Laminin-Rezeptor (LRP/LR) mit dem Prion Protein beleuchtet. Dabei konnte gezeigt werden, das beide Proteine an der Zelloberfläche von neuronalen Zellen interagieren und daß LRP/LR für die Internalisierung von rekombinantem PrPC notwending ist. Diese …
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Metadherin Functions As A Laminin Receptor That Is Essential For Metastasis and Is Associated With Poor Survival In Osteosarcoma
… adhesion to the ECM through interaction with Laminin. In total, these observations establish MTDH as a promising target for therapeutic interventions in metastatic osteosarcoma. The novel connection between MTDH and extracellular laminin also establishes a new paradigm for the function of MTDH …
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Characterization of the 37-kDa/67-kDa laminin receptor as the cell surface receptor for the cellular prion protein
… remain obscure. Recently, the human 37 kDa laminin receptor precursor (LRP), which represents the precursor of the human 67 kDa high-affinity laminin receptor (LR), was identified as a binding partner for the cellular prion protein in a yeast two-hybrid screen. In order to characterize the …
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Fibronectin and Laminin, extracellular matrix proteins, have an origin in mesoderm tissue and promote anterior neural tube closure in zebrafish
… neural tube. I hypothesized Fibronectin (Fn) and Laminin (Lam), extracellular matrix proteins, have an origin in mesoderm tissue and promote anterior neural tube closure. Supporting my hypothesis, the mRNA for extracellular matrix genes lama1, lama2, lamb1a, lamc1, fn1a, and fn1b were all …
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Laminins in blood vessel development and disease -functional aspects in angiogenesis, atherosclerosis, and muscular dystrophy
… Vital components of all basement membranes are laminins, heterotrimeric combinations of different laminin chain isoforms. The different laminins and their subunits largely have a developmental and tissue specific distribution. To determine the function of laminin isoforms in pathological …
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Immunfluoreszenzhistochemische Untersuchung der Expression von Laminin, Fibronektin, Tenascin und der Kollagene I, III, IV und VI während der einzelnen Stadien der chronisch venösen Insuffizienz
… Untersucht wurde die Expression von Laminin, Fibronektin, Tenascin und der Kollagene I, III, IV und VI. Hierbei zeigten alle untersuchten Proteine eine Zunahme der Expression im Stadium des Stauungsekzems im Vergleich zu gesunder Haut. Die Expression ist im Stadium der …
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Role of Laminins in the Development of the Peripheral Nervous System
<p>To investigate the function of laminins in peripheral nerve development, the laminin γ1 gene was specifically disrupted in Schwann cells. Disruption of laminin γ1 gene expression resulted in depletion of all other laminin chains known to be expressed in Schwann cells. Schwann cells lacking …
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Modulation of TGF-beta and extracellular matrix in retionic acid-induced cleft palate
… collagen I, III, and IV, fibronectin, tenascin, laminin and hyaluronate were investigated in normal palate development. Collagen I and collagen IV, laminin, and hyaluronate proved to have spatial-temporal patterns of localization during palatal shelf growth and reorientation. However, using …
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Cadherin-Mediated Cell-Cell Interactions Regulates Phenotype And Morphology of Nucleus Pulposus Cells Of The Intervertebral Disc
… and NP cell phenotype when cultured upon soft, laminin-containing substrates; however, the mechanisms that regulate metabolism and phenotype of these NP cells are not understood. N-cadherin is a cell adhesion molecule that is present in juvenile NP cells, but disappears with age. The goal of …
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H36-alpha7 is a novel integrin alpha chain that is developmentally regulated during skeletal myogenesis
… that H36-$\alpha$7$\beta$1 selectively binds to laminin. The expression of H36-$\alpha$7 on secondary myoblasts during the development of the limb in vivo corresponds with the appearance of laminin in the limb, with the responsiveness of secondary myoblast proliferation to laminin, and with the …
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Gene expression studies of pregastrulation development: the basement membrane is essential for cell differentiation
… in development, tissue homeostasis and disease. Laminins, a major BM component, are multidomain proteins, consisting of three polypeptide chains (α, β and γ). During pregastrulation development, stem cells convert and epithelial tissues are formed. This process is faithfully mimicked in vitro by …
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Synthetic Peptide Ligand Mimetics and Tumor Cell Motility
… inhibits invasion of prostate carcinoma cells on laminin-5. This effect is adhesion independent and reversible. The inhibition of migration by HYD1 involves a dramatic remodeling of the actin cytoskeleton resulting in increased stress fiber formation and actin colocalization with cortactin at the …
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Cell Patterning: Building Living Neural Networks
… versus stripes of extracellular matrix protein (laminin or pleiotrophin with or without polylysine). These substrates were fabricated by sequentially binding biomolecules to substrates with polydimethylsiloxane microstamps. On laminin/polylysine versus polylysine, 80% of neurons near the border …
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