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Showing 1 to 11 of 11 for “"laminar shear stress"”.
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Effect of laminar shear stress on gene regulation, protein synthesis, and protein secretion by cultured human endothelial cells
To test the hypothesis that wall shear stress generated by blood flow may regulate endothelial cell expression of blood clot dissolving proteins or vasoactive proteins, an in vitro perfusion system was used to expose human umbilical vein endothelial cell monolayers to well defined, laminar fluid …
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Differential regulation of genes and transcription factors in vascular endothelial cells exposed to uniform and disturbed laminar shear stress
Thesis (Ph. D.)--Massachusetts Institute of Technology, Whitaker College of Health Sciences and Technology, 1997.
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Mechano-sensitivity of nuclear lamin proteins in endothelial cells
… lamin A/C. Blood flow in arteries is generating shear stress that is mostly applied on endothelial cells that align along inner blood vessel wall. At the same time, endothelial cells are also under stretch by periodic arterial pulses. Considering the fact that atherosclerosis is prone to …
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Effect of shear stress on surface membrane potassium ion permeability of calf pulmonary artery endothelial cells (Potassium ion)
This study aims to determine the effect of shear stress on membrane potassium (K$\sp+$) permeability in vascular endothelial cells. Cultured monolayers of calf pulmonary artery endothelial cells, preloaded with $\rm \sp{86}Rb\sp+$, were subjected to different levels of fluid shear stress in the …
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Endothelial cell impact on smooth muscle cell properties: role of hemodynamic forces
… forces are of particular interest and include shear stress, the frictional force generated by blood as it drags against the endothelium, and cyclic strain, transmural pressure due to the pulsatile nature of blood flow. Both forces can profoundly modulate vascular endothelial metabolism and …
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Hemodynamic regulation of blood-brain barrier phenotype: A cooperative effort linking adherens and tight junction complexes
… link between BBB phenotype and flow-associated shear stress. In this regard, our research has demonstrated that exposure of BBMvEC’s to physiological levels of shear stress in vitro can upregulate tight junction protein expression and enhance protein immunolocalization at the cell-cell border, …
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The role of death-associated protein kinase in endothelial apoptosis under fluid shear stress
… in regions of disturbed fluid flow and low shear stress. Apoptosis, or programmed cell death, must be properly regulated to maintain homeostasis in the vascular wall. The loss of apoptosis control, as seen in low shear stress regions, is implicated in various diseases such as atherosclerosis …
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Ex-vivo-Expansion perikardialer Patchstrukturen : zur Frage des Einflusses von zyklischem Stress und laminaren Strömungsbedingungen auf das Ex-vivo-Remodelling perikardialer Patchstrukturen
… systems up to 20 days, one group under cyclic stress conditions observing the influences of different frequencies (f equal to or less than 10/min) on tissue-engineered samples and the other under laminar shear stress conditions using cell-seeded and cell-free fibrin gel scaffolds to compare …
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Divergent regulation of zinc metallopeptidases by shear stress in macrovascular endothelial cells via an NADPH oxidase - superoxide pathway
… vasoregulation. Flow-associated laminar shear stress (LSS) imparts an atheroprotective stimulus on the vascular endothelium, causing realignment of endothelial cells in the direction of flow and strengthening of intercellular tight junction barriers. Conversely, disturbed shear …
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Regulation von oxidativem Stress durch biomechanische Kräfte und fettreiche Ernährung im Herz-Kreislaufsystem
… Diabetes mellitus, Adipositas, Bewegungsmangel, Stress und hohem Alter wird eine pathophysiologisch erhöhte Bildung reaktiver Sauerstoffspezies (ROS) als Ursache für deren Entstehung diskutiert. NAD(P)H-Oxidasen, von denen 7 Isoformen der katalytischen Nox-Untereinheiten bekannt sind, stellen …