Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"lamina-associated domains"”.
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Modeling Genome Organization in Eukaryotic and Prokaryotic Cells Using Folding Determinant Interactions
… systems. For mammalian cells, I model how lamina-associated domains (LADs) and specific fold interactions (SFIs) contribute to nuclear architecture. By contrasting random polymer ensembles with models incorporating sparse specific interactions, I demonstrate that LAD–lamina tethering and …
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Mechanistic and Epigenetic Partitioning of Lamina-Associated Chromatin Revealed by a Genome-Wide Imaging Screen
… as a site of heterochromatin organization, where lamina-associated domains (LADs) play a crucial role in transcriptional repression and genome stability. However, the molecular mechanisms that tether LADs in human cells remain poorly defined. To address this gap, I conducted the first genome-wide, …