Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"lamin A/C"”.
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Mechanism of Atrial Fibrillation in Lamin A/C Cardiomyopathy
Atrial fibrillation (AF) is a common arrhythmia with a complex genetic basis, yet the molecular mechanisms linking rare and common variants remain unclear. Polygenic risk score (PRS) assessment in the UK Biobank and All of Us cohorts shows that the risk of incident AF in carriers of …
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UNDERSTANDING LAMIN A/C AND ITS ROLES IN DISEASE PATHOLOGIES
THE NUCLEAR LAMINA, COMPRISED OF THE A AND B-TYPE LAMINS, REGULATES CHROMATIN ORGANIZATION AND GENE TRANSCRIPTION. MOUSE MODELS WERE DERIVED TO STUDY THE ROLE OF THE A-TYPE LAMINS IN INTESTINES AND SKIN HOMEOSTASIS AND ONCOGENESIS. MICE LACKING LMNA IN THEIR GASTROINTESTINAL (GI) EPITHELIUM HAVE NO …
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A putative interaction between mitochondrial cytochrome c oxidase subunit II (COX II) to lamin A/C and LAP2α in colon epithelial cells.
The lamina is a cage-like structure, composed of lamins, found underneath the inner nuclear membrane (INM). In mammals, Lamins are type V intermediate filaments. Three genes encode seven different lamin proteins. These genes are LMNA, LMNB1 and LMNB2. Lamins are classified into A- and B-types. …
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Mechano-sensitivity of nuclear lamin proteins in endothelial cells
… and aging cells, implicating dysfunctions of lamin A/C in aging process and atherosclerosis, as HGPS is caused by a mutated form of lamin A/C. Blood flow in arteries is generating shear stress that is mostly applied on endothelial cells that align along inner blood vessel wall. At the same …
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Extracts from the prairie plant Symphoricarpos occidentalis or the natural product, Pheophorbide a, induce light-dependent vacuolation of human cells
… envelope. Vacuolated cells show an intense lamin A/C signal, in particular at the location of the nuclear envelope derived vacuole. We found that vacuolation appeared independent of protein synthesis, vacuolated cells were alive at 16 h, and light co-treatment increased extract toxicity …
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Functional gene analysis in cultured vertebrate cells using siRNA mediated gene silencing
… prozessiert das Zellkernprotein prelamin A durch endoproteolytische Entfernung der carboxyterminalen 16 Aminosäuren zu reifem lamin A. Die Unterdrückung dieser proteolytischen Spaltung des prelamins A durch RNAi gegen FACE1 resultiert in der Akkumulation von nicht prozessiertem …
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A Study of Machine Learning Approaches for Integrated Biomedical Data Analysis
… related to Duechenne Muscular Dystrophy(DMD) and Lamin A/C(LMNA) using the integration of multi-omics data. We proposed a novel method which allows us to integrate proteins, mRNAs and miRNAs to find disease related pathways. The goal of the second project is to develop a personalized …
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Changes in the Oligodendrocyte Progenitor Cell Nuclear Lamina During Ageing
… was to explore a possible role of the nuclear lamina (a nucleoplasmic protein scaffold) in the functional response of OPCs to the mechanical properties of their microenvironment. Work in this thesis identified changes in the expression levels of the nuclear lamina proteins Lamin A/C and Lamin …
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Differentiation Induces Dynamic Alterations in Mesenchymal Stem Cell Nuclear Architecture and Mechanotransduction
… of nuclear structural elements (i.e. lamin A/C and chromatin). These changes increased nuclear mechanical properties, resulting in changes tto he manner in which MSCs respond to external mechanical perturbation. In addition, through a series of micromechanical experiments, the …
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Single-Objective Tilted Light Sheet Illumination with Exchange-PAINT and Deep Learning for Fast, Accurate, and Precise 3D Single-Molecule Super-Resolution Imaging in Mammalian Cells
… super-resolution imaging of nuclear lamina proteins lamin B1, lamin A/C, and emerin, and the microtubule protein alpha-tubulin. The single-objective dithered light sheet achieves a localization precision below ten nanometers in xy and below 12 nanometers in z, enabling a range of …
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Biophysical and gene expression change in living cells by force-induced mechanotransduction
… an intact F-actin, cytoskeletal tension, Lamin A/C, or substrate rigidity. Other protein pairs in Cajal bodies exhibit different magnitudes of fluorescence resonance energy transfer. Dynamic cyclic force induces tiny phase lags between various protein pairs in Cajal bodies, suggesting …
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Mechanisms of epigenetic regulation in epidermal keratinocytes during skin development. Role of p63 transcription factor in the establishment of lineage-specific gene expression programs in keratinocytes via regulation of nuclear envelope-associated genes and Polycomb chromatin remodelling factors.
… accompanied by decreased expression of nuclear lamins (Lamin A/C and Lamin B1), proteins of the LINC complex (Sun-1, nesprin-2/3) and Plectin. Plectin links components of the nuclear envelope (nesprin-3) with cytoskeleton and ChIP-qPCR assay with adult epidermal keratinocytes showed p63 binding …
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Identificazione delle Lamine di tipo A come nuovi substrati della protein chinasi Akt/PKB
… antibody. This study presents evidence of A-type lamins as novel nuclear substrates of Akt. Lamins are type V intermediate filaments proteins found in the nucleus of higher eukaryotes where, together with lamin-binding proteins, they form the lamina at the nuclear envelope, providing mechanical …
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Effect of uptake pathway on non-viral gene delivery in vitro and in vivo
… inhibit expression of clathrin, caveolin, or lamin A/C (negative control) protein expression (HeLa-CLTC, HeLa-CAV, HeLa-LAM, 231-CLTC, 231-CAV, and 231-LAM) in the presence of tetracycline. Using the shRNA Tet-on system, we demonstrated ~90% clathrin knockdown and ~60% caveolin knockdown in …
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The role of death-associated protein kinase in endothelial apoptosis under fluid shear stress
… mechanotransduction and the role of nuclear lamina is further evaluated.^ Using bovine aortic endothelial cells, we have shown that laminar shear stress modulates DAPK expression. Initially, our study examined the time-dependent effects of conditioning cells with shear stress on apoptosis …