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Showing 1 to 20 of 54 for “"lamin"”.
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Lamin C2
In der Kernlamina von Spermatozyten von Nagetieren sind die Lamin A-Genprodukte, Lamin A und C, durch eine meiosespezifische Splicingvariante ersetzt. Dieses Lamin C2 unterscheidet sich auffallend von den somatischen Varianten in Struktur, Menge und Verhalten. Durch eine ektopische Expression von …
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Lamin A and lamin C are differentially dysfunctional in autosomal dominant Emery-Dreifuss muscular dystrophy
… mutations in the LMNA gene which gives rise to lamin A and lamin C proteins by alternative splicing. These A-type lamins, together with B-type lamins, form the nuclear lamina, a network of intermediate filament proteins underlining the nuclear envelope. In order to ascertain the role lamin A and …
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Mechanism of Atrial Fibrillation in Lamin A/C Cardiomyopathy
Atrial fibrillation (AF) is a common arrhythmia with a complex genetic basis, yet the molecular mechanisms linking rare and common variants remain unclear. Polygenic risk score (PRS) assessment in the UK Biobank and All of Us cohorts shows that the risk of incident AF in carriers of …
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Mechano-sensitivity of nuclear lamin proteins in endothelial cells
… and aging cells, implicating dysfunctions of lamin A/C in aging process and atherosclerosis, as HGPS is caused by a mutated form of lamin A/C. Blood flow in arteries is generating shear stress that is mostly applied on endothelial cells that align along inner blood vessel wall. At the same …
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UNDERSTANDING LAMIN A/C AND ITS ROLES IN DISEASE PATHOLOGIES
THE NUCLEAR LAMINA, COMPRISED OF THE A AND B-TYPE LAMINS, REGULATES CHROMATIN ORGANIZATION AND GENE TRANSCRIPTION. MOUSE MODELS WERE DERIVED TO STUDY THE ROLE OF THE A-TYPE LAMINS IN INTESTINES AND SKIN HOMEOSTASIS AND ONCOGENESIS. MICE LACKING LMNA IN THEIR GASTROINTESTINAL (GI) EPITHELIUM HAVE NO …
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Charakterisierung der Kernmembranproteine Lamin-B-Rezeptor und Bocksbeutel von Drosophila melanogaster
… von Drosophila melanogaster: Drosophila Lamin B Rezeptor (dLBR), ein integrales Membranprotein der inneren Kernmembran; Bocksbeutel alpha und Bocksbeutel beta, LEM-Domänen Proteine sowie deren potentiellen Interaktionspartner Drosophila Barrier-to-Autointegration Factor (dBAF).
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Lamina assoziierte Polypeptide 2, Lamin-B-Rezeptor und Lamine : Untersuchungen an Vertebratenmodellen
… Teilprojekten Untersuchungen an integralen (Lamina assoziiertes Polypeptid 2, Lamin B Rezeptor) und peripheren Membranproteinen (Lamine) der in inneren Kernmembran durchgeführt. Eines der am besten untersuchten integralen Membranproteine der inneren Kernmembran ist das Lamina assoziierte …
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Postmeiotische Expression und funktionelle Charakterisierung von Lamin B3 in der Spermatogenese der Maus
Die Lamine gehören zu einer Familie von Proteinen, die als strukturelle Hauptelemente die Kernlamina ausbilden, einen wesentlichen Bestandteil der Kernhülle eukaryontischer Zellen. In Säugern exprimieren differenzierte somatische Zellen die Lamine A, C, B1 und B2. Die Kernhülle in Keimzellen …
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A putative interaction between mitochondrial cytochrome c oxidase subunit II (COX II) to lamin A/C and LAP2α in colon epithelial cells.
The lamina is a cage-like structure, composed of lamins, found underneath the inner nuclear membrane (INM). In mammals, Lamins are type V intermediate filaments. Three genes encode seven different lamin proteins. These genes are LMNA, LMNB1 and LMNB2. Lamins are classified into A- and B-types. …
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Diverse Roles Of Nuclear Intermediate Filaments In Proliferating Cells
… role of two nuclear intermediate filaments - Lamin A and Lamin B1 in the proliferating cells of embryonic hearts and cancer. Lamin B1 is upregulated together with proliferation genes in at least 15 cancers curated in The Cancer Genome Atlas (TCGA), whereas Lamin A trends align with ‘matrix …
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Novel Intermediate Filaments in the Nuclear Envelope: Molecular Cloning and Analysis of Lamins A and C
<p>Lamins A, B and C are the major polypeptides of the nuclear lamina, the filamentous meshwork intercalated between chromatin and the inner nuclear membrane. Amino acid sequences have been deduced from cDNA clones of human lamins A and C which show identity with the exception of an additional 98 …
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The role of death-associated protein kinase in endothelial apoptosis under fluid shear stress
… mechanotransduction and the role of nuclear lamina is further evaluated.^ Using bovine aortic endothelial cells, we have shown that laminar shear stress modulates DAPK expression. Initially, our study examined the time-dependent effects of conditioning cells with shear stress on apoptosis …
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Molekulare Charakterisierung, Expressionsmuster und Interaktionen der Lamina-assoziierten Polypeptide 2 (LAP2) in Xenopus laevis
Lamina-assoziierte Polypeptide 2 (LAP2) in Vertebraten sind bis auf zwei Ausnahmen integrale Membranproteine der inneren Kernmembran, die durch unterschiedliches Spleißen eines einzigen Gens entstehen. Während die aminoterminale Domäne, die allen LAP2 Isoformen gemeinsam ist, in Interphasezellen …
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The Application of a Statistical Model Investigating Reactive Oxygen Species in Premature Ageing Syndromes
… the post-translational processing of the protein lamin A. Lamin A is a Class V intermediate filament protein which resides in the cell nucleus, where it forms a cage-like structure against mechanical strain and is involved in transcriptional regulation, protecting the cell’s genome from damage. …
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Dynamic organization of chromosomes in the mammalian cell nucleus
… character looked at the influence of the nuclear lamina in constraining and determining a higher order nuclear architecture by selectively interacting with mid-to-late replicating chromatin. Simultaneous immunodetection of lamin B on two-color replication labeled neuroblastoma cell nuclei revealed …
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Identificazione delle Lamine di tipo A come nuovi substrati della protein chinasi Akt/PKB
… antibody. This study presents evidence of A-type lamins as novel nuclear substrates of Akt. Lamins are type V intermediate filaments proteins found in the nucleus of higher eukaryotes where, together with lamin-binding proteins, they form the lamina at the nuclear envelope, providing mechanical …
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Role of Zmpste24 in Prelamin A Maturation.
<p>The nuclear lamins form a karyoskeleton providing structural rigidity to the nucleus. One member of the lamin family, lamin A, is first synthesized as a 74 kDa precursor, prelamin A. Following the endopeptidase and methylation reactions which occur after farnesylation of the CAAX-box cysteine, …
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Functional gene analysis in cultured vertebrate cells using siRNA mediated gene silencing
… prozessiert das Zellkernprotein prelamin A durch endoproteolytische Entfernung der carboxyterminalen 16 Aminosäuren zu reifem lamin A. Die Unterdrückung dieser proteolytischen Spaltung des prelamins A durch RNAi gegen FACE1 resultiert in der Akkumulation von nicht prozessiertem …
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Changes in the Oligodendrocyte Progenitor Cell Nuclear Lamina During Ageing
… was to explore a possible role of the nuclear lamina (a nucleoplasmic protein scaffold) in the functional response of OPCs to the mechanical properties of their microenvironment. Work in this thesis identified changes in the expression levels of the nuclear lamina proteins Lamin A/C and Lamin …
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1, Structural and Functional Studies of Human Replication Protein A; 2 DNA Damage Responses and DNA Repair Defects in Laminopathy-Based Premature Aging.
… aging is caused by defective maturation of lamin A and linked to accumulation of DNA double-strand breaks (DSBs). However, how lamin A dysfunction leads to genome instability and premature aging is not understood. Here evidence showed that in HGPS and RD fibroblasts DNA damage checkpoints …
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