Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 33 for “"lamellipodia"”.
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Abelson Kinase Based Regulation of Tumor Cell Invasion in HNSCC
… spread. HNSCC invasion is mediated in part by lamellipodia and invadopodia, two actin-based structures responsible for facilitating invasive movement. Key signaling pathways that govern lamellipodia and invadopodia production are hyperactivated or overexpressed in HNSCC, including EGFR, Src, …
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Tetraspanin KAI1/CD82 inhibits cell migration-related cellular events via reorganizing actin network
… elongated cellular extensions and a lack of lamellipodia. Live imaging demonstrated that the formation of lamellipodia and retraction of extensions were deficient upon KAI1/CD82 overexpression.</p> <p>The deficiency in developing motility-related cellular events was accompanied by defects in …
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Morphology and Mechanics of the Actin Cytoskeleton
… provides for structural support for the cell. Lamellipodia are extensions of the cellular cytoskeleton at the leading edge of a crawling cell generated so that the cell can extend, and thereby move in a particular direction. In the first two chapters, we focus on morphological characteristics …
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The Cytoskeletal Mechanisms of Cell-Cell Junction formation in Endothelial Cells
… between cells is mediated by protruding lamellipodia. Upon their retraction, cells maintain contact through thin bridges formed by filopodia-like protrusions connected by VE-cadherin-rich junctions. Bridges share multiple features with conventional filopodia, such as an internal actin …
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Function and Regulation of the Cell Fate Determinant Numb in Polarized Epithelial Cells
… hepatocyte growth factor (HGF)-induced lamellipodia formation and cell dispersal – early steps in epithelial-mesenchymal transition (EMT). In Numb-depleted cells, Rac1-GTP loading is enhanced, which corresponds with increased rate in loss of cell-cell adhesion and increased lamellipodia …
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The role of a monomer/dimer equilibrium and the C-terminal tail in regulating translocation of sphingosine kinase 1 to the plasma membrane of breast cancer cells
… (GFP)-SK1 (mGFP-SK1) from the cytoplasm to lamellipodia in the PM of MCF-7L breast cancer cells. In addition, carbachol also induced translocation of WTmGFP-SK1 to lamellipodia, albeit in an ERK-independent manner.;In contrast, S1P induced the ERK-independent translocation of WTmGFP-SK1 to …
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The role of the extracellular matrix in neuronal development and perinatal brain injury
… (DIV0–21), with expression of HA and HASs on lamellipodia, filopodia, immature neurites, differentiated processes, and synapses (Chapter 3). Notably, HA was expressed earlier and more widely than PNNs. Neurons also expressed Hyal1–3 mRNA. In Chapter 4, pharmacological inhibition of HAS …
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Evaluating the effects of acoustic stimulation on fibroblast cell migration and muscle fibre formation.
… L929 cell lines, particularly the formation of lamellipodia and filopodia. Overall lamellipodia was the most prominent actin structure displayed by the lung cell (LL24), whereas filopodia was the most prominent actin feature displayed by the fibroblast derived from subcutaneous areolar/adipose …
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Investigations into membrane protrusions mediated by IRSp53 IMD
… regulators Rac and Cdc42 in the formation of lamellipodia and filopodia, respectively. IRSp53 interacts with many other effectors in the formation of these structures, via various protein interaction domains. IRSp53 also contains an IMD (IRSp53/MIM homology domain), which is able to induce …
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Mena 11a-isoform specific regulation of actin cytoskeleton organization and cell behavior
… Arp2/3 recruitment to the leading edge of lamellipodia. Mass spectrometry analysis demonstrates that Mena11a is phosphorylated. The expression of a nonphosphorylatable mutant of Mena 1Ia does not retain the ability of Mena11a to dampen membrane protrusion, decrease G-actin incorporation at …
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Molecular Basis of HDL-Mediated Endothelial Cell Migration and Reendothelialization
… protein kinases. Rapid initial stimulation of lamellipodia formation by HDL via SR-BI, Src kinases and Rac is also demonstrable. Paralleling the in vitro findings, carotid artery reendothelialization following perivascular electric injury is blunted in apolipoprotein A-I null (apoA-I-/-) mice, …
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MECHANO-CHEMICAL FEEDBACK VIA CONTACT PERCOLATION REGULATES PHASE TRANSITION AND TRANSCRIPTIONAL STATE IN HETEROGENEOUS BREAST CANCER
… local density and collective motility, marked by lamellipodia formation and RAB5A-dependent actin remodeling in control cells. In both 2D and 3D models, contact-driven percolation triggers a pro-inflammatory transcriptional switch in non-RAB5A cells, mediated by secreted factors and direct …
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Tyrosine Phosphorylation of Villin: Effects on Actin Dynamics, Cell Morphology and Cell Migration
… PLC-and for its localization to the developing lamellipodia in a motile cell. Collectively, these studies define how biophysical events such as cell migration are actuated by biochemical signaling pathways involving tyrosine phosphorylation of actin binding proteins, in this case villin.</p>
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The Function of CARMIL1 in Migrating Cells
… the CARMIL-CP complex as a key regulator of lamellipodial actin assembly and of lamellipodial dynamics. Membrane ruffling at the leading edge of motile cells and macropinocytosis were also found to be dependent on the CARMIL1-CP interaction. This is consistent with macropinocytosis and …
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Roles of coagulation factor XIII in the functions of blood platelets
… FXIII leading to the formation of filopodia and lamellipodia. Adhesion to FXIIIa was mediated through integrin-dependent mechanisms, since it was abolished by treatment with RGDS. Moreover, platelet adhesion to FXIIIa was reduced partially, but significantly by either the specific integrin dnbPs …
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Invesitagating the role of the guanine nucleotide exchange factor P-Rex1 in cell invasion
… characterised by extensive membrane ruffling and lamellipodia formation. P-Rex1 modulates the 2D migration of fibroblasts and potently stimulates their in vitro invasion. These phenotypes are dependent on Rac1, PI3 kinase and GPCR signalling and can be stimulated by growth factor mediated …
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Understanding the Organization, Location, and Interactions of Actin-based Structures During Drosophila Dorsal Closure
… membrane and continuous with the extending lamellipodia and filopodia. Thus, medioapical arrays are modified cell cortex.</p>
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Crosstalk Signaling Between cAMP and Calcium on the Leading Edge of Migrating Human Arterial Vascular Smooth Muscle Cells
… cells. Thus, we show that PDE1C localizes at lamellipodia formed by polarized/migrating HASMCs and coordinates a series of hyper-localized Ca2+ and cAMP signaling events within these structures which chronically antagonize their formation. Moreover, we show that these events are dependent on …
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The role of actin isoforms in cancer adhesion of the endothelium during metastasis
… changes, such as cell protrusions called lamellipodia. Cytoplasmic actin has a role in the formation of these structures as well as one specific isoform, γactin, themselves being associated with cancer. Extracellular vesicles (EVs) are small lipid-bound vesicles that act as communicators …
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Calcium, actin and the spectrin skeleton: Responses to swelling and shrinking perturbations.
… of newly constituted leading edge (filopodia and lamellipodia) that we termed actipodia. Microinjection of live molluscan neurons with fluorescent G-actin also indicated that F-actin could reorganize as actipodia around the VLD membrane within 5 minutes. Cytochalasin incubated neurons formed VLDs …
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