Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 194 for “"lactone"”.
-
Halo enol lactone and protio enol lactone inhibitors of alpha-chymotrypsin: Mechanism and stereospecific behavior of inhibition
… of inactivation of $\alpha$-chymotrypsin by enol lactones was performed. Halo enol lactones, 3-(1-naphthyl)-6(E)-(iodomethylene)tetrahydro-2-pyranone ($\alpha$Np6I) and 3-phenyl-6(E)-(bromomethylene)tetrahydro-2-pyranone ($\alpha$Ph6Br), showed burst kinetics in the inactivation of the enzyme, …
-
Precursors to the potent odorant wine lactone.
… of menthiafolic acid, a precursor to wine lactone in wine. (R)-Menthiafolic acid was synthesised and then taken through acid hydrolyses to confirm its conversion to wine lactone under wine-like conditions and to determine the chirality of the resultant product. A Gas Chromatography/ Mass …
-
Studies directed towards the synthesis of the macrocyclic lactone Aspicilin
Contains fulltext : 30119_studditot.pdf (Publisher’s version ) (Open Access)
-
Studies on the anti-cancer potential of sesquiterpene lactone parthenolide
Parthenolide is the major sesquiterpene lactone responsible for the bioactivities of Feverfew (Tanacetum parthenium), a traditional herbal medicine which has been used in treatment of fever, migraine and arthritis for centuries. This compound has long been known to have potent anti-inflammatory …
-
Stability evaluation of selected anthelmintic macrocyclic lactone compounds and formulations
… used for control of these parasites. Macrocyclic lactone (ML) compounds such as avermectins (e.g. abamectin, ivermectin, eprinomectin) and milbemycins (e.g. milbemycin oxime and moxidectin) are among most important anthelmintics, used extensively and globally. However, excessive and uncontrolled …
-
Production of Bio-based Lactone Monomers for Intrinsically Recyclable Plastics
… for the production of α-cyclohexyl-δ-valerolactone (CVL) starting from formaldehyde and δ-valerolactone (DVL). We developed a continuous gas-phase reactor using alkaline earth oxides supported on silica as catalysts for an aldol condensation reaction. CaO and BaO showed 90% and 83% …
-
N-(3-Oxododecanoyl)-L-Homoserine Lactone in the Breast Tumor Microenvironment
The tumor microenvironment is a well-recognized contributor to cancer progression in solid tumors. Cancer cell interactions with abnormal extracellular matrix, tumor associated immune and stromal cells, and aberrant fluid flow all contribute to cancer progression. Breast tumors are often …
-
N-acylhomoserine lactone regulation of adhesion and biofilm differentiation in Serratia marcescens MG1
… signal identified as N-butanoyl-L-homoserine lactone (C4-HSL). The aim of this study was to determine the role of C4-HSL in surface colonisation (adhesion and biofilm formation). In this thesis, the development of a novel biofilm in S. marcescens MG1 is described. The biofilm comprises of an …
-
A Metabolomics-Based Analysis of Acyl-Homoserine Lactone Quorum Sensing in Pseudomonas aeruginosa
… These QS systems use diffusible acyl-homoserine lactone (AHL) signalling molecules to infer environmental parameters, including bacterial population density, and to coordinate behaviour across bacterial communities. This dissertation describes an investigation into the relationship between QS and …
-
Synthesis and biological research of the pseudomonas aeruginosa signaling compounds PQS and N-3-oxo-dodecanoyl-L-homoserine lactone
… signaling molecules 3-oxo-C12-homoserine lactone and Pseudomonas quinolone signal were synthesized so that the mammalian cellular responses to their presence via an infection could be studied. It was hypothesized that differing combinations of the signaling molecules would result in the up …
-
The synthesis and evaluation of halo and protio enol lactone Pro-Val pseudodipeptides as potential inhibitors of human leukocyte elastase
… from aryl-substituted halo and protio enol lactones. In this study, the enantiomerically pure disubstituted protio and halo enol lactones 11a-c and 12a-b were prepared as potential inhibitors of the serine protease human leukocyte elastase (HLE). These lactones are incorporated into a …
-
Halo Enol Lactones as Enzyme-Activated Irreversible Inhibitors of Alpha-Chymotrypsin: I. The Effect of Lactone Substitution Pattern. Ii. Alpha - Amino-Functionalized Lactones
Halo enol lactones with a phenyl group situated (beta) or (gamma) to the lactone carbonyl group were prepared to compare their effectiveness as enzyme-activated irreversible (suicide) inhibitors for (alpha)-chymotrypsin with the activities of the corresponding (alpha)-substituted lactones. The …
-
XYLARIC ACID, D-ARABINARIC ACID (D-LYXARIC ACID), L-ARABINARIC ACID (L-LYXARIC ACID), AND RIBARIC ACID-1,4-LACTONE; SYNTHESIS AND ISOLATION - SYNTHESIS OF POLYHYDROXYPOLYAMIDES THEREFROM
<p>This dissertation describes the nitric acid oxidation of the pentoses D-xylose, L-arabinose, D-arabinose, and D-ribose to produce xylaric acid, L-arabinaric acid (L-lyxaric acid), D-arabinaric acid (D-lyxaric acid), and ribaric acid, respectively, or salts therefrom. Isolation of the aldaric …
-
XYLARIC ACID, D-ARABINARIC ACID (D-LYXARIC ACID), L-ARABINARIC ACID (L-LYXARIC ACID), AND RIBARIC ACID-1,4-LACTONE; SYNTHESIS AND ISOLATION - SYNTHESIS OF POLYHYDROXYPOLYAMIDES THEREFROM
<p>This dissertation describes the nitric acid oxidation of the pentoses D-xylose, L-arabinose, D-arabinose, and D-ribose to produce xylaric acid, L-arabinaric acid (L-lyxaric acid), D-arabinaric acid (D-lyxaric acid), and ribaric acid, respectively, or salts therefrom. Isolation of the aldaric …
-
Synthesis and chemistry of 1,4-oxathianes and 1,4-oxathian-3-ones
… these studies and involved the synthesis of the lactone 1,4-oxathian-3-one S.S-dioxide again with the aim of alkylating this sulfone for use as the precursor required in the Ramberg-Bäcklund reaction. Investigations included acid/alcohol cyclizations and catalytic oligomerization/depolymerization …
Page 1 of 10