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Showing 1 to 20 of 108 for “"lactide"”.
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Synthesis of polymers and copolymers of lactide through titanium initators
… of biocompatible and biodegradable polymers of lactide through non-toxic titanium alkoxide nitiators. The research objectives focused on the preparation of polylactides in both solvent and solventless media, to produce materials with a wide range of molecular weights. The polylactides were fully …
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Investigation of protein destabilization in monodisperse poly(lactide-co-glycolide) microparticles
Poly(lactide-co-glycolide) (PLG) microspheres are a powerful choice for controlled release of protein therapeutics. However, several properties of PLG microspheres, particularly hydrophobicity and acidic microenvironment, may have detrimental effects on encapsulated protein, causing structural …
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Synthesis and Characterization of Poly(lactide) Functional Oligomers and Block Copolymers
… consisting of poly(ethylene oxide) and poly(lactide) have great potential for formulating drug delivery systems. Our approach was to synthesize poly(ethylene oxide-b-D,L-lactide), (PEO-b-PDLLA), block copolymers with controlled molecular weights and good functionality on the poly(ethylene …
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Indium complexes and their role in the ring-opening polymerization of lactide
… the ROP of β-butyrolactone ε-caprolactone and lactide and is the first reported indium-based catalyst for lactide or β-butyrolactone ROP. Kinetic studies of 3 for ROP of LA revealed that catalyst was well-behaved, and that the rate was first order with regard to lactide and catalyst. The …
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Functional Self-Assembled Poly (L-Lactide) Nanoparticles For Targeted Delivery of Bioactive Agents
… cancer therapy.</p> <p>In the first part, poly(lactide-co-glycolide) fumarate (PLGF) NPs were used for the delivery of recombinant human bone morphogenetic protein-2 (rhBMP-2) and a peptide isolated from the BMP-2 protein. They were encapsulated in or grafted to the NPs for their sustained …
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Fundamental Studies of Various Poly(L-lactide)/clay Nanocomposite Systems by in-situ Polymerization
… In this study, in situ polymerizations ofpoly(L-lactide)-clay nanocomposites were conducted using various montmorillonite organoclays (PLLA-MMT). When using tin (Il) 2-ethylhexanoate (Sn(Oct)2) as the catalyst, the reaction is believed to initiate from stannous alkoxides, formed from hydroxide …
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Amphiphilic Poly(2-isopropyl-2-oxazoline)-block-poly(lactide) Nanoparticles as Drug Delivery Vehicles
… poly(2-isopropyl-2-oxazoline)-block-poly(DL-lactide) and poly(2-isopropyl-2-oxazoline)-block-poly(L-lactide) (PiPOx-b-PDLLA and PiPOx-b-PLLA) nanoparticles was obtained via Fluorescence Spectroscopy. Additionally, loading and release studies were carried out with hydrophobic curcumin …
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Synthesis and Characterization of Injectable Star-shaped Poly(Lactide-co-Glycolide-co-Acrylate) Macromers
… Among these synthetic polymers, poly(lactide-co-glycolide) (PLGA) copolymers have been popularly used either as temporary scaffolds for cell transplantation to regenerate tissues or as drug carriers for delivery of bioactive molecules. Our laboratory has done researches in developing …
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The Degradation and Drug Release Mechanisms of Poly(ethylene glycol)-functionalised Poly(L-lactide) Polymers
Poly(L-lactide) (PLLA) is a well-recognised bioresorbable polymer known to degrade after 1.5 to 5 years by hydrolysis. For certain medical device or drug delivery applications, it would be desirable to reduce this degradation time as strategies for tailoring degradation and drug release rates …
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Bioresorbable Electrospun Tissue Scaffolds of Poly(ethylene glycol-b-lactide) Copolymers for Bone Tissue Engineering
Poly(α-hydroxy esters) are a class of biocompatible resorbable polyesters including poly(lactic acid) (PLA) and poly(glycolic acid) (PGA) that are FDA-approved for clinical use. Preliminary tissue culture studies have demonstrated that these poly(α-hydroxy esters) support bone tissue development …
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The suitability of biodegradable poly(dl-lactide-co-glycolide)75:25 microspheres for the sustained release of antibiotics
… composed of the biodegradable polymer poly (dl-lactide-co-glycolide) [PLCG] 75:25. Topical administration to the wound in hydroxypropylmethylcellulose gel should achieve high local antibiotic concentrations while the two week in vivo half life of PLCG 75:25 removes the need for expensive …
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Studies towards degradable polymers new zinc (II) and palladium (II) complexes as catalysts for lactide polymerization and carbon monoxide
… complexes were used for the production of polylactides (PLAs) functionalized with a drug candidate on a polymer tail. These functionalized polymers displayed slow drug release properties under physiological conditions. Palladium complexes were utilized for the production of a photodegradable …
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Synthesis and Characterization of Polylactide-siloxane Block Copolymers as Magnetite Nanoparticle Dispersion Stabilizers
Polylactide-siloxane triblock copolymers with pendent carboxylic acid functional groups have been designed and synthesized for study as magnetite nanoparticle dispersion stabilizers. Magnetic nanoparticles are of interest in a variety of biomedical applications, including magnetic field-directed …
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Preparation and Characterization of Electrospun Poly(D, L-Lactide-Co-Glycolide) Scaffolds for Vascular Tissue Engineering and the Advancement of an In Vitro Blood Brain Barrier Model
<p>Developing an <em>in vitro</em> Blood Brain Barrier model that will replicate the physiological, anatomical, and functional characteristics of the native BBB has gained significant attention. Such a model would enable prediction of the penetration of CNS targeting drug candidates across the BBB, …
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Bimetallic Main-Group Catalysts for the Synthesis of Advanced Biocompatible, Biodegradable, and Sustainable Polymers
… in the ring-opening polymerization (ROP) of lactide. Furthermore, both random and block copolymerizations of lactide with ε-caprolactone were carried out to achieve control over polymer microstructure and properties. In addition, this dissertation explores the synthesis of …
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Interactions between adult human mesenchymal stem cells and nanofibrous scaffolds of different compositions
… matrix. One is derived solely from Poly-L-lactide acid and the other from Poly-L-lactide/Gelatin (50:50). Before and after culturing, measurements of fiber diameter, thermodynamics, and tensile strength were collected. Studies with primary human MSCs were conducted to characterize the in …
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In vitro inflammatory response evaluation of pre-degraded bioresorbable polymers
Bioresorbable polymers composed of poly(lactide), poly(glycolide) and their related copolymers have become increasingly popular in the biomedical field, and especially for the preparation of bone substitute constructs. However, there are reports of a delayed inflammatory reaction occurring months …
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