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Showing 1 to 20 of 23 for “"lactic acidosis"”.
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Associations of severe hyperlactataemia and lactic acidosis in HIV-infected patients receiving antiretroviral theraphy
Severe symptomatic hyperlactataemia and lactic acidosis (SHLA) are life-threatening events that are occurring at increasing incidence levels in South Africa. Globally, the rise in SHLA cases is closely correlated to the increased accessibility of anti retroviral (ARV) medication for human …
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The influence of monosaccharide types (D-glucose, D-mannose and D- galactose) in inducing lactic acidosis in goats
Call number: LD2668 .T4 1978 M78
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Distinct Neuropsychological Profile and Associated Neurochemical Changes in Individuals with Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-Like Episodes (MELAS)
<p>Background: Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-like Episodes (MELAS) is a maternally inherited progressive multisystemic disorder. Occurrence of seizure and/or stroke-like episode, as well as classic biomarkers (i.e., cerebral lactic acidosis, depleted N-acetylaspartate …
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Analysis, pharmacokinetics, metabolism and pharmacodynamics of labetalol in pregnant and nonpregnant sheep
… including maternal and fetal hyperglycemia and lactic acidosis and a decrease in fetal oxygen content were observed, suggesting potent r32-agonist activity. The lactic acidosis was more pronounced in the fetus than in the ewe. In adult nonpregnant sheep, a 100 mg i.v. bolus administration of …
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Genetic Determinants of Cancer Cell Survival in Tumor Microenvironment Stresses
… (TME) stresses, such as hypoxia or lactic acidosis. Additionally, cancer cells exposed to these stresses are more resistant to therapies, more likely to metastasize and often are worse for patient prognosis. While the presence of these stresses is generally negative for cancer …
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Metabolic alterations to sudden introduction of high carbohydrate diets in ruminating dairy bull calves
… sodium bicarbonate (.9% of DM) attenuated lactic acidosis in animals which consumed high quantities of concentrate. Although some animals in the buffer group suffered from acidosis, sickness was potentiated in nonbuffer group. Buffer inhibited the decline of ruminal fluid pH, and the …
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Pharmacogenetics of stavundine : role of genetic variation in mitochondrial DNA and polymerase gamma among adult Malawian HIV/AIDS patients
… such as peripheral neuropathy, lipodystrophy, lactic acidosis and hyperlactatemia but show interpatient variability. Studying African populations is likely to open the door for the population to benefit from novel diagnostic tools and drugs developed on the basis of pharmacogenomics knowledge. …
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Glucose-6-Phosphatase in Metabolic Disease and Cancer
… anomalies in GSD1a, including debilitating lactic acidosis and hyperuricemia, are assumed to be consequences of glucose-6-phosphate accumulation, although the mechanism has not been explored in detail. Late sequela of GSD1a includes the formation of liver adenomas and carcinomas without …
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Whole Blood Mitochondrial DNA Depletion in Human Immunodeficiency Virus-Infected Children
… significant toxic effects, including fatal lactic acidosis. Little is known about mitochondrial DNA (mtDNA) in human immunodeficiency virus (HIV) infected children who face a lifetime exposure to these agents. We performed a cross sectional observation of mtDNA levels in whole blood in a …
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Effect of experimental complex III deficiency on respiratory chain assembly and function
… aminoaciduria, cholestasis, iron accumulation, lactic acidosis, and early death, MIM 603358). To clarify the mechanisms of BCS1L-related disorders, especially possible changes in supercomplex formation, the specific aims of this thesis were to investigate CIII assembly and supercomplexes in a …
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Aggiustamenti metabolici durante il recupero nell'Interval Training: studio in laboratorio e sul campo in atleti di mezzofondo e velocità prolungata
… repetitions of interval training, was related to lactic acidosis. The heart rate charts in both groups of athletes and with respect to the two workloads showed a progressive increase of the same during recovery periods, while CO2excess as well as VO2 and Ve were not modified. On the basis of our …
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Cost effectiveness analysis of two alternative interventions for the integration of Tenofovir into South Africa's public sector First Line Antiretroviral treatment regimen
… related toxicities or side effects, particularly lactic acidosis, lypodystrophy, peripheral neuropathy, and anaemia. However, developing country governments have been limited to these NRTI choices due to the higher cost of alternative treatment options. There is compelling logic that the life long …
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Unraveling the Structure and Assessing the Quality of Protein Interaction Networks with Power Graph Analysis
… cytopathy: emph{Mitochondrial Encephalomyopathy, Lactic acidosis, and Stroke-like episodes} (MELAS), and iii) we investigate the biochemical causes behind the enhanced biocompatibility of tantalum compared with titanium.
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An Analysis of Mitochondrial DNA in Rett Syndrome and Other Neurodegenerative Disorders
… disease MELAS (mitochondrial encephalomyopathy, lactic acidosis, strokelike symptoms) in single human lymphoblasts and identified an intercellular distribution of mutant and normal mtDNA. This differs from analyses performed in LHON and MERRF (myoclonic epilepsy, ragged red fibers) pedigrees …
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The Prevalence of Antiretroviral-Therapy-related Adverse Reactions, Hospitalisation, and Mortality among People Living with HIV in Africa-A systematic review and Meta-Analysis
… reported include hepatotoxicity, kidney injury, lactic acidosis, skin, neurologic, and hematologic reactions. The antiviral implicated, are non-nucleoside reverse transcriptase inhibitors, nucleoside/tide reverse transcriptase inhibitors, and protease inhibitors. The pediatric population was …
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The effeciveness and determinants of effectiveness of antiretroviral therapy for adults in the Western Cape Province, South Africa
… 3 years on ART). Symptomatic hyperlactataemia or lactic acidosis as well as lipodystrophy were strongly associated with women initiating ART with a high initial body mass. The third paper explores the effectiveness of ART when co-administered with tuberculosis treatment, identifying that …
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The effectiveness and determinants of effectiveness of antiretroviral therapy for adults in the Western Cape Province of South Africa
… 3 years on ART). Symptomatic hyperlactataemia or lactic acidosis as well as lipodystrophy were strongly associated with women initiating ART with a high initial body mass. The third paper explores the effectiveness of ART when co-administered with tuberculosis treatment, identifying that …
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Bioinformatic Approaches to Study Mitochondrial DNA Heteroplasmy
… people. Mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes (MELAS) is a primary mitochondrial disease that mainly affects the nervous system and muscles. It is most often caused by a heteroplasmic mutation at position m.3243A>G. To investigate the disease’s …
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Insulin resistance, chronic heart failure and potential treatment
… infarction. Despite previous concerns of lactic acidosis, there is now evidence that metformin may not only be safe but could potentially be useful in the setting of CHF. We have conducted a randomised double-blind, placebo-controlled trial testing the hypothesis of reversing IR with …
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Metabolic changes in cellular components of the vasculature : examining the link between diabetes and cancer
… conditions, which can potentially lead to lactic acidosis. This increased lactate production from the endothelial cells following metformin administration led to an overall decrease in the intracellular pH hypothesized to be caused from the release of lactate from the cell through the …
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