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Showing 1 to 6 of 6 for “"lactamization"”.
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Single electron studies of acylammonium intermediates, zinc-mediated carboxylations in flow, and the total synthesis of (–)-inthomycin C.
… diastereoselective keck allylation, and lactamization to furnish the desired ring. Compared to the recent publications using the photoredox method, our method takes advantage of the ⍺-radical's inherent reactivity through both an intermolecular and intramolecular capturing reaction, …
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GREEN CATALYTIC STRATEGIES FOR THE PRODUCTION OF BIOBASED BUILDING-BLOCKS
… Subsequently the catalysts were tested in the lactamization of GVL with butylamine. (T=200 °C, P(H2) = 10 bar and GVL:BuNH2 = 1:1) The reaction conditions and the set up were improved to lower the impact avoiding catalyst pre- treatment and high hydrogen pressure. The best results were achieved …
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Palladium-mediated C–H Functionalization of Aliphatic Amines via High Valent Palladium(IV) Intermediates
… reagent enabling a Pd-catalyzed C–H arylation-lactamization process to form a 7-membered ring lactam product. Finally, a stoichiometric study on benzylamine-derived palladacycles led to the discovery of an unprecedented dehydrogenative intramolecular C–C coupling reaction under oxidative …
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Efforts toward an enantioselective total synthesis of (–)-oxazolomycin B and simplified chemical probes for proteomics studies; pharmacophore-directed retrosynthesis applied to gracilin A : simplified bioactive derivatives.
… nucleophile-catalyzed Michael-proton transfer lactamization organocascade to the decagram scale production of a γ-lactam applicable to the total synthesis of the oxazolomycins and analogs thereof. An exhaustive experimental procedure is described for the synthesis of this γ-lactam starting …
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Chlorinated amino acids in peptide production
A new method for the production of peptides through biological expression was developed, utilising lactonisation-prone chlorinated amino acids for latent peptide bond digestion. Incorporation of halogenated amino acids into proteins is possible due to the inherent inability of the biological …
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Chlorinated amino acids in peptide production
A new method for the production of peptides through biological expression was developed, utilising lactonisation-prone chlorinated amino acids for latent peptide bond digestion. Incorporation of halogenated amino acids into proteins is possible due to the inherent inability of the biological …