Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 28 for “"lääketiede"”.
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1800-luvun kolerapandemiat: lääketieteellinen ja yhteiskunnallinen kehitys
… loppupuoliskolla. 1800-luvun alussa länsimainen lääketiede perustui vielä vahvasti antiikin oppeihin. Hoito ja tautien preventio perustui humoraalioppiin ja miasmateoriaan. Jo edellisillä vuosisadoilla oli kuitenkin hiljalleen kehittynyt ajatusta mikroskooppisten pieneliöiden välittämistä …
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VEGFR-3 and Tie pathways in vascular network formation
The blood and lymphatic vascular systems are essential for life, but they may become harnessed for sinister purposes in pathological conditions. For example, tumors learn to grow a network of blood vessels (angiogenesis), securing a source of oxygen and nutrients for sustained growth. On the other …
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Anxiety, depression, and anger in the borderland of chronic pain
Chronic pain is a long-lasting burdensome condition. Comorbid psychological symptoms are common in chronic pain patients and they tend to worsen the treatment outcome. The aim of this cross-sectional study was to assess the prevalence of psychiatric comorbidity in chronic pain patients and to …
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Globus and dysphagia : clinical features and diagnostics
Globus, a non-painful sensation of a lump in the throat, is a common symptom; however, little is known about the etiology, and the causes have remained controversial. Dysphagia is a multifaceted symptom. Identifying the stage of the swallowing process at which the problem occurs directs us to …
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Economic evaluations in adopting new vaccines in the Finnish national vaccination programme
This study presents the materials, methods, and results of the economic evaluations of 7-valent pneumococcal conjugate vaccination (PCV7) programme, influenza vaccination programme and human papillomavirus (HPV)-associated cost of illness study, all of which were used in the vaccine adoption …
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Prevalence and determinants of respiratory symptoms, asthma, chronic bronchitis and allergic sensitization in Helsinki : A comparison between Finland, Sweden and Estonia : The FinEsS studies - Helsinki I
Objectives: To assess the prevalence and risk factor profiles of respiratory symptoms, asthma and chronic bronchitis in Helsinki, and to compare these results with those for Sweden and Estonia. Other important aims were to evaluate the prevalence and determinants of type 1 sensitization in …
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Inflammatory and coagulation disturbances in acute pancreatitis
Acute pancreatitis (AP), a common cause of acute abdominal pain, is usually a mild, self-limited disease. However, some 20-30% of patients develop a severe disease manifested by pancreatic necrosis, abscesses or pseudocysts, and/or extrapancreatic complications, such as vital organ failure (OF). …
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Measurements of adequacy of anesthesia and level of consciousness during surgery and intensive care
The adequacy of anesthesia has been studied since the introduction of balanced general anesthesia. Commercial monitors based on electroencephalographic (EEG) signal analysis have been available for monitoring the hypnotic component of anesthesia from the beginning of the 1990s. Monitors measuring …
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New approaches to improve the cord blood unit hematopoietic progenitor cell content
Cord blood is a well-established alternative to bone marrow and peripheral blood stem cell transplantation. To this day, over 400 000 unrelated donor cord blood units have been stored in cord blood banks worldwide. To enable successful cord blood transplantation, recent efforts have been focused on …
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Acute Lymphoblastic Leukemia in Adolescents and Young Adults in Finland
In recent reports, adolescents and young adults (AYA) with acute lymphoblastic leukemia (ALL) have had a better outcome with pediatric treatment than with adult protocols. ALL can be classified into biologic subgroups according to immunophenotype and cytogenetics, with different clinical …
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Regulation and Function of GATA Transcription Factors in Adrenocortical Tumors and Granulosa Cells
Transcription factors play a key role in tumor development, in which dysfunction of genes regulating tissue growth and differentiation is a central phenomenon. The GATA family of transcription factors consists of six members that bind to a consensus DNA sequence (A/T)GATA(A/G) in gene promoters and …
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Intestinal Adaptation in Pediatric Short Bowel Syndrome : Controlled Assessment of Duodenal Mucosa after Extensive Bowel Resection
Background. Although extensively studied in experimental models, human data on intestinal adaptation in short bowel syndrome (SBS) is very limited. Aim of the study. We studied mucosal homeostasis of the duodenum in children with intestinal failure (IF) both during parenteral nutrition (PN) and …
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Biliary atresia : growth, bone health and neurocognitive and motor outcome in childhood and adolescence
Background: Biliary atresia (BA) is a rare cholangiopathy of infancy. Without treatment, inflammation and obstruction of the biliary tracts leads to liver cirrhosis and death within the first 2 years of life. BA is treated with portoenterostomy (PE), in which an exit for bile from the liver is …
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Molecular Studies on Pathogenesis, Prognostic Factors, and New Treatment Options for Ovarian Granulosa Cell Tumors
Granulosa cell tumor (GCT) is the second most common subtype of ovarian cancer, representing 5% of all ovarian malignancies. GCTs are characterized by an indolent course of disease, with a 5-year survival rate of over 90%. However, recurrences occur in 20-30% of patients, also those with …
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Epidemiology of blood component use in Finland
Previously reported differences in transfusion practices suggest that transfusion protocols and clinical transfusion decisions may often be inappropriate. To change and monitor practices requires a follow-up system. A healthcare-integrated data-gathering system could provide the required …
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Flavivirus Infections in Travelers : Insights into Prevention of Japanese Encephalitis and Diagnostics of Dengue
The mosquito-borne flavivirus infections Japanese encephalitis (JE) and dengue pose a considerable disease burden in the tropical and subtropical regions of the world. Sometimes these infections also affect international travelers visiting areas endemic for the diseases. This thesis addresses the …
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Occupational exposure, socio-economic status and mortality in asthma and chronic obstructive pulmonary disease (copd) in the Helsinki region, Finland
After musculoskeletal and mental disorders, chronic obstructive lower airway diseases are highly prevalent worldwide and are a leading cause of disability. They are also a major cause of premature death, surpassed by only cardiovascular diseases and neoplasms. Asthma and chronic obstructive …
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Characteristics of organ donors and logistics of organ procurement for short- and long-term outcomes in abdominal organ transplantation
Organ transplantation is a medical procedure in which a patient’s dysfunctional organ is replaced with a graft that is usually received from an organ donor. Solid- organ transplantation is the best treatment option especially in end-stage kidney and liver failure. Pancreas transplantation, on the …
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Premorbid hazardous alcohol consumption in critically ill patients
Hazardous alcohol consumption is a global health problem. It has been reported to predispose patients treated in intensive care units (ICUs) to complications and weaken their prognosis. However, the identification of hazardous alcohol consumption is challenging. Various validated questionnaires …
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Bone strength in early childhood : Associations with vitamin D and motor development
Bone health during childhood has gained attention, as early bone mass accrual significantly influences skeletal health in adulthood. Higher peak bone mass achieved in early life is considered protective against osteoporosis and fractures later in life. Various factors, including genetics, diet, …
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