Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"kynurenine pathway"”.
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The involvement of the kynurenine pathway in the pathogenesis of multiple sclerosis
… of MS. Over the past decade, involvement of kynurenine pathway (KP) has been implicated in many neurological diseases such as Alzheimer’s disease, Huntington diseases and amyotrophic lateral sclerosis. Increasing evidences indicate that the KP is also involved in MS. The aim of this thesis is …
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Stress and inflammation regulate the kynurenine pathway dioxygenases in a glia‐ and tissue‐specific manner
… rate-limiting for tryptophan metabolism by the Kynurenine Pathway. While accumulating evidence supports an interconnection between symptoms of depression and increased Kynurenine Pathway activity, the cellular specificity underpinning DO regulation by stress and inflammation remain poorly …
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Expression and regulation of the rate-limiting enzymes of the kynurenine pathway in the mouse brain
… over the past 30 years. A leading theory is Kynurenine Pathway activation in relation to inflammation- or stress-induced depression-like behaviors. There has been a tremendous amount of data connecting activated immune system (or hypothalamic-pituitary-adrenal axis), increased kynurenine …
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The Current Role of Kynurenine Pathway Interventions in Oxidative Stress and Redox Homeostasis in the Context of Aging and Cancer
… in old individuals. In recent years, the kynurenine pathway –the main route to metabolize tryptophan in the cell– has emerged as a therapeutic target in several age-related diseases, including cancer. Intermediate metabolites in the kynurenine pathway have immunological and redox …
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Investigation into the biochemical changes in Tourette Syndrome with a potential for pharmacological manipulation
Kynurenine (KYN) is the first stable metabolite of the kynurenine pathway, which accounts for over 95% of tryptophan metabolism. Two previous studies by this research group reported elevated plasma KYN in Tourette syndrome (TS) patients when compared with age and sex matched controls and another …
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Biochemical aspects of Tourette's Syndrome
Kynurenine (KYN) is the first stable metabolite of the kynurenine pathway, the major route of tryptophan. (TRP) metabolIsm. In the liver, cortisol-inducible tIyptophan-2,3-dioxygenase (TDO) is the first enzyme and rate limiting step. In extrahepatic tissues, it is superceded by …
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Kynurenines in neurological disorders
The kynurenine pathway is thought to be involved in neurological disorders but its precise role and the mechanisms involved have yet to be established. Tryptophan can be metabolised via this pathway to produce the neurotoxic N-methyl-D-aspartate (NMDA) receptor agonist, quinolinic acid (QUIN), and …
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Novel Functions of the Transcription Factor Aryl Hydrocarbon Receptor (AHR) and Its Tryptophan-Derived Ligands in Cancer Cells
… levels of Trp and its metabolites in the kynurenine pathway, specifically increasing the expression of Trp transporters SLC7A5, SLC1A5, and the enzyme AFMID. Elevated levels of these components were observed in immortalized colon cancer cells lines and patient tissues, with a significant …
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Metabolomics of cerebrospinal fluids to identity novel biomarkers as a predictive tool for brain inflammatory conditions
… biomarkers and understand the biochemical pathways involved in neuroinflammation. With metabolites as the downstream products of cellular function, the application of metabolomics data is to understand the pathogenesis of neuroinflammatory mechanisms involved in encephalitis. Preliminary …
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Oxidative, inflammatory and vascular factors in Alzheimer's disease
… o- and m-tyrosine as well as metabolites of the kynurenine pathway, quantitative MALDI-TOF assay of hemorphins and LCMSMS based proteomics, to identify proteins with altered expression levels in AD relative to control brain tissue. A variety of regional differences have been observed in the …
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Inflammatory Mechanisms And Vulnerability For Major Depression: From Animal Models To Drug Treatment
… LPS injection and to modulate the expression of kynurenine pathway enzymes, which may also represent important mediators for inflammation-related depression. We also investigated if genetic susceptibility to depression was associated with changes of the immune/inflammatory system. Indeed, since …
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Capillary electrophoresis instrumentation and applications for the analysis of neural systems
… our collaborators indicating a lack an enzymatic pathway. While serotonin is an important and well-studied tryptophan metabolite, we have begun expanding our system to detect metabolites in the kynurenine pathway. In fact, this pathway is responsible for the majority of tryptophan metabolism in …
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Maternal stress signature and infant neurodevelopment: determining the beneficial effects of human milk oligosaccharides - an in vitro study
… in tryptophan metabolism from the serotonin pathway towards the kynurenine pathway which impacts key metabolites associated with neurodevelopment. All of these changes can have negative effects on placental and foetal brain development in utero. In this study, we used in vitro models to …
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Microbial Metabolite Regulation of Microglial AHR Signaling in Alzheimer’s Disease
… blood plasma measured alterations in tryptophan pathways. Microglial AHR and inflammatory cytokine expression were characterized by flow cytometry. Additionally, human HMC3 microglial cells were treated with indole metabolites and lipopolysaccharide (LPS) to assess inflammatory responses <em>in …