Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"kupffer cell"”.
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DEVELOPMENT OF IN VITRO NON-ALCOHOLIC STEATOHEPATITIS (NASH) MODEL FOR DRUG TESTING AND PATHOGENESIS STUDIES
… currently has no effective intervention. Hepatocellular ballooning is one of the key features of NASH diagnosis. Due to their scarcity, it is difficult to study in vivo and isolate for in vitro investigations. How ballooned hepatocytes form and its role in NASH progression is poorly understood. …
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Use of methionine sulfoximine to dissect the role of glutamine synthetase and glutamine in progression of acute liver failure
… in the body. Glutamine is required by immune cells for generation, propagation and maintenance of an immune response. </p> <p>To induce acute liver failure (ALF) in mice, animals were given intraperitoneal injections of E. coli lipopolysaccharides (LPS) and sugar D-galactosamine (D-GalN). When …
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α-Lipoic Acid Attenuates Ischemia Reperfusion Injury of the Rat Liver
… during this injury comprise depletion of ATP, Kupffer cell activation with subsequent formation of reactive oxygen species and inflammatory response. Depending on the severity of IRI, cell damage leads to necrotic or apoptotic liver cell death, resulting in organ dys- or even nonfunction. The …
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The Impact of Lipid Nanoparticle Chemistry on RNA Delivery and Therapeutic Outcomes
… escape of 5A2-SC8 LNPs from endosomes at early cell incubation time points. Overall, the results indicated that PEG lipid anchoring and chemical structure modulated RNA delivery. Although most LNPs accumulate in the liver after intravenous administration (suggesting that liver delivery is …
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KUPFFER CELLS¿ MITOCHONDRIAL PLASTICITY AFFECTS SYSTEMIC IMMUNO-METABOLISM
BACKGROUND: Kupffer cells (KCs) are hepatic resident macrophages that are essential for liver physiology and contribute to the development of metabolic-associated fatty liver disease (MAFLD). Due to their high plasticity, KCs can maintain immunotolerance and mediate cell-cell interaction within the …
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The role of caspase-1 in liver and adipose tissue during metabolic dysregulation in mouse models on NASH
… (NASH) is defined as lipid accumulation and cellular damage, inflammation and early to modest fibrosis. The progression of NAFLD to NASH remains incompletely understood. Therefore, dissection of mechanisms responsible for progressing this disease is an important area of investigation. In this …