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Showing 1 to 12 of 12 for “"knoevenagel condensation"”.
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Solvent-free Knoevenagel condensation over supported mixed metal oxides catalysts
Submitted in the fulfilment of the requirement for the Master's Degree in Chemistry, Durban University of Technology, Durban, South Africa, 2017.
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Synthesis and biological evaluation of potential anti-cancer agents
… acid derivatives has been prepared by the Knoevenagel condensation of aldehyde and active methylene reagents. These products have been screened against two murine adenocarcinoma cell lines (MAC) which are generally refractive to standard cytotoxic agents. The target of anti-proliferative …
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Characterization of acidic and basic properties of heterogeneous catalysts by test reactions
… (MBOH) and isopropanol and in liquid phase like Knoevenagel condensation were investigated. It was found that the conversion of isopropanol yields propene as the only product over the catalysts which have no redox ability while the reaction was sensitive to nature of the active centers in case of …
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New Derivatization Strategies for Installation of Fixed, Permanent Charges onto Analytes of Biological and Environmental Concern
… of a MAD+ was explored via alkylation and Knoevenagel condensation reactions but proved unfruitful. However, C-alkylation with 6-bromohexanoic acid via carbodiimide coupling, reduction and amine alkylation produced a MAD+ in generous yields. The reaction of this MAD+ with …
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Base stable and basic ionic liquids for catalysis
… network. These ionic liquids catalysed the Knoevenagel condensation between malononitrile and benzaldehyde and were able to be recovered and reused without a decrease in activity.<br/><br/>More strongly basic ionic liquids were synthesised by developing a new class of binary basic ionic …
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Synthesis of Glitazone Analogues as Anti-Diabetic Drugs
… from step one with nucleophilic substitution to Knoevenagel condensation reaction as the final step and were characterized by using a combination of 1H NMR, 13C NMR, IR spectroscopies as well as HRMS analysis. Fourteen final compounds were successfully obtained in good to excellent yields. …
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I. Mechanistic significance of the Si-O-Pd linkage in the cross-coupling of organosilanolates; II. Applications of the water-gas shift reaction in organic synthesis
… has been successfully illustrated in the tandem Knoevenagel condensation/reduction reaction, in which an alkene formed by Knoevenagel condensation is readily reduced under WGSR conditions. The compatibility with several classes of electrophiles and nucleophiles under mild conditions has been …
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Novel applications of surface-modified sporopollenin exine capsules
… in Schotten-Baumann type acylations and Knoevenagel condensations, and the acidic form of sporopollenin in the isopropylidene protection of mannose and preparation of cyclic acetal. As a result, aminated sporopollenin particles were shown to be effective scavengers in Schotten-Baumann …
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Novel palladium-catalyzed synthesis of 3-substituted indoles and its application toward the total synthesis of indolactam V
… substitution of substituted nitrobenzenes and Knoevenagel condensation with formaldehyde was used to prepare 2-nitrostyrenes. Palladium catalyzed N-heteroannulation of 2-nitrostyrenes yielded indoles in 61--99%. For example, reaction of a 0.5 M solution of 1,1-dimethylethyl …
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Synthesis and Characterization of Red and Near-Infrared BODIPY-based fluorophores for various Biological Applications
… and lysyl-BODIPY conjugates, prepared using Knoevenagel condensation reaction, an attractive strategy for the expeditious synthesis of π-extended BODIPYs in moderate to high yields. The effects of the styryl substituents on their photophysical properties and in vitro photodynamic activities …
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An excursion into the synthesis of novel flavanones
… the approach was changed to using a Knoevenagel condensation reaction between an activated β-ketoester derivative of 2- hydroxyacetphenone and para-nitrobenzaldehyde according to the optimised aldol reaction conditions. Although this successfully delivered chemically the required …