Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"knockout mutation"”.
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Impaired virulence factor production in a dihydroorotate dehydrogenase mutant (pyrD) of Pseudomonas aeruginosa.
… research in our laboratory showed that when knockout mutations were created in the pyrB and pyrC genes of the pyrimidine pathway in Pseudomonas aeruginosa, not only were the resultant mutants auxotrophic for pyrimidines but they were also impaired in virulence factor production. Such a …
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The role of the human endonuclease VIII-like 1 and 3 in the repair of DNA replication blocking lesions
… DNA ICLs. With the hNEIL3 catalytic knockout mutation K81A, elimination of activity on three- and four-stranded DNA ICLs was confirmed. hNEIL1 was recently shown to be ubiquitinated by the E3 ubiquitin-ligase, tripartite motif-containing protein 26 (TRIM26). Here, TRIM26 was …
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The streptomyces cytoskeletal protein (Scy) is a key component of the tip organising centre for polarized growth in streptomyces coelicolor
… 51-mer repeat structure. To study Scy, a scy knockout mutation was generated. The phenotype of the scy mutant suggests that it plays a significant role in cell shape, growth and chromosome positioning. Translational fluorescent protein fusions to scy were made and the subcellular localisation …
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Regulatory dynamics of transcription factors TBX18 and WT1 in mouse prostate development
… precursor cells, we obtained a conditional knockout mutation of the Wt1 gene and tested the effects of Wt1 loss of function in prostate development. Crossing the conditional mutants with animals carrying a prostate-specific Cre allele, we identified a severe over-proliferative phenotype in …