Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 337 for “"knockout mice"”.
-
Functional Characterization of CRIP1a Knockout Mice
… of CRIP1a by characterizing the first CRIP1a knockout (KO) mouse line. The absence of CRIP1a was confirmed in KO mice using quantitative PCR and immunoblotting. I hypothesized that CRIP1a KO mice would exhibit enhanced CB1 receptor-mediated G-protein activity in the CNS, as well as …
-
Characterization of Inducible SMC-specific Drosha Knockout Mice
… A transgenic animal model to study SMC-specific knockout of Dicer, one of two RNase III proteins in miRNA biogenesis, showed that contractile motility in the mutant intestine was dramatically decreased (Park, Yan, et al., 2011). The purpose of this study was to investigate the function of Drosha, …
-
Generation and characterization of spred-2 knockout mice
… organism was still unclear. Therefore, Spred-2 knockout mice were generated using a gene trap approach. The Spred-2 deficiency was verified on RNA and protein levels and the lack of functional Spred-2 protein in mice caused a dwarf phenotype similar to achondroplasia, the most common form of …
-
Enhanced methylglyoxal formation in cystathionine γ-lyase knockout mice
… manner in A-10 cells. In 6-22 week-old CSE knockout male mice (CSE⁻/⁻), mice with lower levels of vascular H₂S, we observed a significant elevation in MG levels in both plasma and renal extracts. Renal triosephosphates were also significantly increased in the 6-22 week-old CSE⁻/⁻ mice. To …
-
THE RESPIRATORY RESPONSE OF TRPV1 KNOCKOUT MICE TO TRIGEMINAL IRRITANTS
… administer volatile compounds to unanesthetized mice which were restrained in a double chamber plethysmograph. Respiration rate depression for female wild type (C57Bl/6J) mice was compared to female Trpv1 knockout mice for a variety of compounds in an attempt to determine if TRPV1 is responsible …
-
Cardiovascular Characterization of Cx40/Panx1 Single and Double Knockout Mice
… cellular signaling functions we proposed that mice lacking both a connexin and a pannexin would have a severe phenotype. To investigate this possibility we crossed Panx1 null mice with Cx40 knockout mice and characterized the first global connexin/pannexin double knockout mouse. Intriguingly, …
-
Mechanisms of Hypoxia-Induced Neurovascular Remodeling in PlGF Knockout Mice
… growth factor (PlGF) is unknown. Using PlGF knockout (PlGF-/-) mice exposed to whole body hypoxia (10% oxygen) for 7, 14 and 21-days, we show that PlGF-/- animals exhibit a delay in the angiogenic response of the brain to hypoxia. PlGF-/- microvessels had a significant increase in fibrinogen …
-
Synaptic Plasticity in the Cerebral Cortex of Fragile X Knockout Mice
… of the visual cortex was examined in young Fmr1 knockout and wildtype mice. The rate of developmental synaptogenesis between the two genotypes was similar, but Fmr1 knockout mice exhibited levels of synaptic protein synthesis lower than those of wildtype mice. The role of FMRP in …
-
Respiratory Biomarkers in Kv1.1 Knockout Mice, a Model for Temporal Lobe Epilepsy
… nature of epilepsy and mortality in Kv1.1 knockout (KO) mice, a model of temporal lobe epilepsy and SUDEP. We reported respiratory abnormalities in KO mice using the methacholine (MCh) challenge, indicating that increased breathing rate, apnea and respiratory failure is associated with …
-
Developmentally Related Increased Seizure Susceptibility to Pentylenetetrazole in Fragile X Knockout Mice
… experiments have demonstrated that fragile X knockout mice are more susceptible than control animals to the chemoconvulsant PTZ as adults, but not as juveniles. Furthermore, the temporal progression suggests that there is a developmental involvement in this seizure susceptibility. The …
-
Expression of Capn6 During Osteoclast Differentiation In Wild-Type and Hdac4 Knockout Mice
… the expression of Capn6 in wild-type and HDAC4 knockout osteoclasts. Methods: qRT-PCR was preformed to assess Capn6 expression in wild-type and HDAC4 knockout mice over days 0-4 of osteoclast differentiation. Results: Levels of Capn6 expression increased later in osteoclast differentiation in …
-
Using knockout mice to study the molecular mechanisms that shape auditory nerve responses
… C57BL/6 and 129/SvJ (because they are used in "knockout" generation). Two lines with targeted deletion of inner ear genes were also studied. The cochlea in mouse responds to frequencies octaves higher than in humans or most other mammals; nevertheless, most other AN characteristics were …
-
Genetic approaches to studying coronary heart disease in SR-BI/apoE double knockout mice
… deposits in vessel walls. SR-BI/apoE double knockout (dKO) mice are a novel mouse model of human CHD, exhibiting spontaneous coronary occlusive atherosclerosis, myocardial infarction, cardiac dysfunction and premature death. This model represents a unique system in which to study the two …
-
Using Hi-Spots to investigate in vitro network dysfunction in Cysteine String Protein ? knockout mice
… occurring in Cysteine String Protein (CSP)?-/- mice. CSP? is a presynaptic protein thought to have co-chaperone like functions, mice lacking CSP? are born alive but show progressive weakness and neuronal degeneration soon after birth (Fernandez-Chacon, Wolfel et al. 2004). Hi-Spots formed from …
-
Elevated colorectal cancer risk in the hnRNP I knockout mice treated with azoxymethane/dextran sulfate sodium
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2025-10-19 without embargo terms
-
Immune responses alter in heterogeneous nuclear ribonucleoprotein I knockout mice with medium protein diet or probiotic intervention
The student, Yingwei Zhao, submitted this Thesis for approval on 2021-04-27 at 14:06.
Page 1 of 17