Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"knock-out mouse model"”.
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Yellow Fever: Role of Heterologous Flavivirus Immunity on Urban Emergence
… Next, we utilized an interferon α/β receptor knock-out mouse model to determine the role of pre-existing DENV-2 and ZIKV immunity in YF virus infection, and to determine mechanisms of cross-protection. We utilized African and Brazilian YF strains and found that DENV-2 and ZIKV immunity …
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Phenotypic characterisation of the tremor mutant and AAV mediated aspartoacylase gene transfer in the rat model of Canavan disease
… characterization of the tremor rat, an animal model of Canavan disease, and a proof of principle gene transfer study in this model. The phenotype of the tremor rat is examined at the genetic, molecular, cellular, neurochemical, physical and behavioural levels, and tremor mutants are described …
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HEDGEHOG SIGNAL TRANSDUCTION IN EFFECTOR IMMUNE CELLS
… receptor engagement. Using a conditional knock-out mouse model and pharmacological blockade, I find that the Hh pathway is critical for tumour cell killing in murine and human NK cells. Mechanistically, the Hh pathway impacts the kinetics of NK immune synapse formation, without affecting …
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Aspects of T cell development contributing to autoimmunity.
… resistance in the non-obese diabetic (NOD) mouse. The role of thymic expression of TGF-β was dissected by using TGF-β type II receptor cre/lox conditional knock out mouse model. By transplanting bone marrow to irradiated recipients we restricted the phenotype to hematopoietic stem cells. …
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Mtorc1 Signaling In Memory Formation and Dysfunction
… inhibitor of mTORC1, has been shown to improve outcome. On the other hand, chronic elevated levels of mTORC1 are required for axonal regeneration of injured peripheral nerves and increased synapse growth after TBI. These results suggest that this mTORC1 could be a potential therapeutic target …
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The roles of DPPA2, DPPA4 and SMARCA5 in mouse zygotic genome activation, epigenetic reprogramming and development
The epigenetic remodelling that takes place in order to transform a fertilised oocyte into an embryo and then a whole organism, is one of the most intriguing cellular transformations in biology. The whole process starts with the meiotic resumption of an oocyte when the translational activation of …
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Neuropathologic characterization of a canine model of mucopolysaccharidosis IIIB and additional studies in anti-inflammatory therapy and neuroinflammatory kinetics
… therapies are currently being examined. A knock-out mouse model and several naturally occurring animal models of MPS IIIB have been reported. To date, the mouse and canine models of MPS IIIB have been utilized for pathogenesis and therapeutic studies. The canine model is an ideal animal …
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Efficacy of enzyme replacement therapy in α-manosidosis mice
… Maus-LAMAN) in einem Alpha-Mannosidose Maus Modell durchgefuehrt. Dazu wurde einzelnen Gruppen von Alpha-Mannosidose-knock out-Maeusen eine einmalige Dosis LAMAN injiziert und die Tiere wurden nach verschiedenen Zeiträumen getoetet. Diese Vorgehensweise hatte folgende Ziele: die Clearance des …