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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

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Showing 1 to 20 of 66 for “"knock-out mice"”.

  1. Artificial Intron Technology to Generate Conditional Knock-Out Mice

    Thomas-Gordon, Amber N, <p>0000-0002-1319-5789</p>2020

    … gene expression. Such gene manipulation brings about significant findings and revelations in comprehending more about embryonic development, cellular and physiological functions, and disease pathology. Current methods used to produce conditional knockouts have limitations on conditional allele …

    uthsc Repository record

  2. ELECTROPHYSIOLOGICAL INVESTIGATION OF HIPPOCAMPAL SYNAPTIC PLASTICITY IN DEAF-1 KNOCK-OUT MICE

    Ghosh, Aniruddha2017

    … with ID. Previous behavioral studies in mice with a brain specific conditional neuronal knock outs (NKO) of deaf 1 gene exhibited memory deficit and anxiety-like behavior. These deaf 1 NKO mice represent a convenient model for the study of the effects of ID on both in vivo and in vitro …

    siu-theses Repository record

  3. Characterisation of Vti1b and Vti1a proteins and generation of knock-out mice.

    Atlachkine, Vadim2012

    … und kleinen Mäusen. Die normal großen Vti1b-knockout Mäuse haben keine nachweisbaren Defekte im Transport zum Lysosom, aber die Hepatozyten der kleinen Vti1b knockout Mäusen zeigen eine Verlangsamung im Proteintransport von späten Endosomen zu Lysosomen, erkennbar z.B. durch verlangsamten …

    goettingen Repository record

  4. Altered Decision Behavior of Dopamine Receptor Knock-out Mice in a Free Binary Choice Task

    곽, 신애2015

    … the difference between actual and predicted outcomes (reward prediction error). However, the extent and nature of dopamine roles in reward-based learning are still under debate. Specific roles of different dopamine receptor subtypes in this process are also unknown. To investigate roles of …

    ajou Repository record

  5. Functional characterization of Pura in vivo and in vitro - Pura knock-out mice and Pura DNA unwinding activity

    Ding, HaiyanLudwig-Maximilians-Universität

    … in vivo remains unclear. In this study, Pura knock-out mice (KO) were generated using homologous recombination techniques in ES cells. The Pura gene locus was isolated from 129/SvJ Mouse Genomic Library and partially sequenced. A targeting vector using positive and negative selection was …

    lmu-germany Repository record

  6. A COMPARISION OF DELTA-9-TETRAHYDROCANNABINOL DEPENDENCE IN C57Bl/6j MICE AND FATTY ACID AMIDE HYDROLASE KNOCK OUT MICE

    Carlson, Brittany Leigh Alice2014

    … elevating endogenous anandamide levels using mice lacking fatty acid amide hydrolase (FAAH), the enzyme responsible for anandamide metabolism, would ameliorate THC dependence. Mice were treated subchronically with a low or high THC dosing regimen and challenged with the CB1 receptor …

    vcu Repository record

  7. Real time course of transmitter release of SSVs and LDCVs; SNARE function analysed in synaptobrevin2 and cellubrevin knock out mice

    Zhao, Ying2012

    Teil 1Die Freisetzung von Neurotransmittern wird durch die Ca2+-abhängige Exocytose von synaptischen Vesikeln vermittelt, die eine sehr schnelle Kinetik der Transmitterfreisetzung aufweist. Mit Hilfe von Kohlefasern als elektrochemische Detektoren wurde die Freisetzung des Neurotransmitters …

    goettingen Repository record

  8. Generation of Endoplasmic Reticulum Protein 28 (ERp28) Knock Out Mice, and Structural and Functional Analysis of its Drosophila Homologue, Wind

    Guo, Chaoshe2012

    … umfasst zwei Teile: (1) die Erstellung von knock-out Mäusen für Erp28, ein Gen, welches für ein Chaperone des Endoplasmatischen Reticulums kodiert, (2) die strukturelle und funktionelle Analyse von Wind, das ERp28-Homolog von Drosophila. Um eine ERp28 Knock-out Maus zu erstellen, musste …

    goettingen Repository record

  9. FN-EDA domain knock-in and knock-out mice, as a model for the study of the hepatic fibronectin (FN) functions

    Moretti, Federico AndreaThe Open University2007

    … attenuated fibrosis in comparison to control mice. The important role of the EDA domain in the activation and proliferation of the hepatic stellate cells (HSCs), these are the key cells responsible for the ECM protein overproduction in the fibrotic processes, is demonstrated for the first time …

    the-open-u Repository record

  10. Investigations on extra- and intracellular retinol-binding proteins

    Frey, Simone K.Universität Potsdam

    … there is still considerable scientific debate about this relation. With the increasing amount of studies investigating the relation of ROH in obesity and type 2 diabetes, basic research is an essential prerequisite for interpreting these results. This thesis enhances the knowledge on this …

    potsdam-diss Repository record

  11. Investigating the role of PABPC5 in mouse physiology

    Gyurova, Hristina DochkovaThe University of Edinburgh2024

    … different to other PABPs, but little is known about its function. PABP5 resides in the gene-poor region of Xq21.3 and published data has identified a patient with premature ovarian insufficiency (POI) carrying a deletion in this region, suggesting a possible link between POI and PABP5. Premature …

    edinburgh Repository record

  12. Neurotrophins and neurotrophin receptors in adult primary sensory neurons

    Karchewski, Laurie AnnUniversity of Saskatchewan2000

    … by conducting a detailed analysis of DRG in p75 knock-out mice. Compared to wildtype controls, p75 knock-out mice show diminished NGF binding affinity, reduced retrograde transport of low quantities of NGF and a more rapid phenotypic switch following injury, suggesting that p75 is important in …

    sask Repository record

  13. The role of salt-inducible kinase in the control of hepatic gluconeogenesis

    Patel, KashyapUniversity of Dundee2014

    … research coupled to physiological readout (e.g. gluconeogenesis).<br/>My studies with phosphopeptide mapping by mass spectrometry followed by verification with well-characterised phospho-specific antibodies revealed that SIK2 was phosphorylated on Ser343, Ser358, Thr484 and Ser587 in …

    dundee Repository record

  14. The Role of Cdk5 in the Regulation of Dopamine Neurotransmission, Neuronal Excitability, and Reward-Related Behavior

    Benavides, David Roger2010

    … we developed several Cre/loxP conditional knock-out systems that allow temporal and spatial control of Cdk5 expression in the adult brain. Loss of Cdk5 in the adult brain increased the psychomotor-activating properties of cocaine and enhanced incentive motivation for food. Behavioral …

    utswmed Repository record

  15. Decoding Gating Properties of the Pannexin1 Channel: ATP Release and pH Sensitivity and the Potential Role in Health and Disease

    Whyte-Fagundes, Paige Alexandra2015

    … epithelium was investigated using Panx1 knock out mice. Functional analysis in vivo confirmed a role in olfaction suggesting that Panx1 is one of several alternative ATP release pathways. Since epileptic and ischemic events cause extracellular pH changes, the role of Panx1 in pH sensing …

    york Repository record

  16. Short Chain Fatty Acids Signaling through the G Protein-Coupled Receptor GPR41 in the Intestine.

    Shaito, Abdullah2010

    … to energy balance. For this purpose Gpr41 knock out mice were generated and rederived as germ free mice. Gpr41 knock out and wild type germ free mice were recolonized as young adults with 2 prominent members of the human distal gut microbial community: the saccharolytic bacterium, …

    utswmed Repository record

  17. The role of a pore-forming protein, Mpeg1, in cytosolic import

    Rodríguez, PabloUniversity of Cambridge2022

    … technology, we have generated an Mpeg1 knock-out mice, and demonstrated that knocking out Mpeg1 in primary cells also inhibits cytosolic import. Given the newly discovered role of Mpeg1 in cytosolic import, I went on to study its role in antigen cross-presentation. Surprisingly we found …

    cambridge Repository record

  18. Gitelman & Gordon: Mirror image syndromes reveal the roles of WNKs in blood pressure homeostasis and novel anti-hypertensive targets

    Siew, KeithUniversity of Cambridge2018

    … remained elusive, however clues came from SPAK knock-out mice which recapitulate GS, the phenotypic mirror image of PHAII, typically caused by activation-inhibiting NCC phosphorylation site mutations resulting in salt-wasting and hypotension. As these mice were also discovered to have reduced …

    cambridge Repository record

  19. [alpha](1,3)galactosyltransferase mediated gene therapy for cancer: developing new models and improving on existing ones

    Hellrung, Daniel2006

    … from C57/BL6 alpha(1,3)galactosyltransferase knock-out mice. The approach, however, is based in part on the sensitivity of tumor cells to the effects of complement. Tumors expressing complement resistance factors such as membrane cofactor (CD46), decay accelerating factor (CD55) and protectin …

    iastate Repository record

  20. PHENOTYPIC AND MOLECULAR CHARACTERIZATION OF A NOVEL P63ALPHA;KO MOUSE MODEL

    URCIUOLI, GLORIAUniversità degli Studi di Milano2023

    … expression of the p63β isoform. Newborn p63α-/- mice die soon after birth and are characterised by cleft palate and digit malformations but exhibit normal skin. Our study indicates that p63α and p63β are not interchangeable in palate and limb development during embryogenesis, whereas expression …

    milano Repository record

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