Global ETD Search
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Showing 1 to 8 of 8 for “"kinins"”.
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Inflammation, kinins, and kinin receptors
… to the group of vasoactive peptides, so-called kinins, which are potent inflammatory mediators. BK, once released from the human contact system, elicits a transient inflammatory response via activation of the constitutively expressed B2 receptor, which desensitizes and is internalized upon …
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Role of kinins in mediating vascular function in healthy pregnancy and pre-eclampsia
… to the development of the maternal syndrome. Kinins are endogenous peptides released by the endothelium that contribute to the regulation of cardiovascular homeostasis by inducing vasodilation, fibrinolysis and angiogenesis. Given that pre-eclampsia is associated with reduced …
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Studies on the angiotensin converting enzyme gene polymorphism and Ace inhibitors
… increases kinin level, for example bradykinin. Kinins have been proposed be involved in the pathogenesis of cough due to ACE inhibitors, a common adverse effect in those prescribed these drugs. A genetic link was proposed to explain the differing susceptibility of subjects to develop cough. …
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Effects of ovokinin on isolated aortas of guinea pigs, normotensive and spontaneously hypertensive rats
… for the degradation of bradykinin and other kinins.
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G protein-coupled receptor regulation: The role of protein interactions and receptor trafficking
… clinically useful drugs act through GPCR. Kinins are proinflammatory peptides that are rapidly produced extracellularly following pathological insults and tissue damage. These peptides act through two GPCR subtypes, B1 (B1R) and B2 (B2R), to elicit numerous inflammatory responses including …
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Kinin System Activation in Vasculitis
… levels were demonstrated in the circulation and kinins were detected at sites of inflammation. We also found that neutrophil-derived proteinase 3 (PR3) cleaves HK liberating a novel vasoactive kinin, termed PR3-kinin. PR3-kinin binds to and activates kinin B1-receptors both in vitro and in vivo. …
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Myocardial fibrosis and pathological hypertrophy in the rat with aorta-constricted hypertension
… other substrates in addition to ANG I, including kinins (which are potent vasodilators); thus, the mechanism of ACE's action may be more complex than mere blockade of ANG II formation. To further distinguish the relative role of hemodynamic and humoral factors in promoting myocardial fibrosis, we …
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Investigation of different blood pressure regulating systems in kininogen-deficient BNK rats
… long-lasting effects like attenuation of plasma kinins or antagonism of the MR seemed to be of importance for the regulation of cardiac function. The absence of plasma KLP during high salt diet was found to be responsible for the enhanced deleterious effects of Na+ leading to cardiac hypertrophy. …