Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"kinetoplastids"”.
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Evolution of vesicular transport in kinetoplastids: dynamics and novel gene products
… to explore compositional conservation between kinetoplastids and Opistokhonts. Overall there is little evidence for large scale expansions or contractions of these protein families, excluding a direct association with parasitism or changes to host range, host immunosophistication or …
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Target Identification and Mechanism of Action Studies in Folate Metabolism in Kinetoplastids
… drug targets. The same cannot be said for the kinetoplastids. Drug discovery programmes have focused on targeting enzymes of the folate metabolism with very little clinical success. Despite showing significant inhibition of the parasitic enzymes, potency is seen to decrease in cellular and …
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The characterisation of calpain-like proteins in Trypanosoma brucei
… family is particularly expanded in ciliates and kinetoplastids, comprising 25 members in the parasite Trypanosoma brucei. Unique to kinetoplastids, some calpain-like proteins contain N-terminal dual myristoylation/palmitoylation signals, a protein modification involved in protein-membrane …
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The genome of Euglena gracilis: Annotation, function and expression
… other protists such as Naegleria, Giardia, and Kinetoplastids, remains to be investigated in detail. Investigating and understanding the biology of this complex organism is a promising way to approach many evolutionary puzzles, including secondary endosymbiotic events and the evolution of …
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Functional diversity and bilobe targeting by the MORN Domain Proteins of Leishmania major
… only been characterized in T. brucei among the kinetoplastids, I chose to study the MORN proteins of L. major an important experimental model. 22 uncharacterized proteins were annotated to contain MORN-repeats in L. major, 14 of which share the feature of exclusively containing MORN-repeats …
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Identification and Characterization of Drug Targets in the Pyrimidine and Purine Pathways of Trypanosoma brucei
… may represent a shared vulnerability unique to kinetoplastids, providing an opportunity to target multiple human pathogens. In contrast to the pyrimidine pathway, the parasite lacks the ability to generate purine nucleotides de novo. As a consequence, they are dependent on the salvage of purine …
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Biochemical characterisation of a novel vaccine candidate against Trypanosoma vivax, the cell surface glycoprotein IFX
… infections can be chronic, and that studies on kinetoplastids have been largely focused on pathogenic trypanosomes (despite large groups of kinetoplastids being non-pathogenic), a separate symbiosis study was included in the thesis on a beneficial symbiosis in nature. Although this work was …
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Unravelling the molecular mechanisms of Leishmania mexicana adhesion in the sand fly vector
… Domain (ARND) family, conserved across kinetoplastids, of which the canonical member is the newly discovered KIAP4. Deletion of KIAP4 severely impaired haptomonad adhesion, with the mutant parasites unable to colonise the sand fly stomodeal valve. Deletion of FAZ2, FAZ5, and FAZ34 …
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Defining D-Arabinose Metabolism in <i>Leishmania major</i> and <i>Crithidia fasciculata</i>
… is possible that D-Arap may be used by all the kinetoplastids to make D-erythroascorbate, a C5 ascorbate analogue similar in structure and physicochemical properties to ascorbate (Vitamin C). In animals and plants, L-ascorbate is involved in cellular defence against oxidative stress. The …
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Analysis of cyclin dependent kinases in Leishmania
… the protozoan parasite Leishmania major. Cdks in kinetoplastids, CRKs, are the key regulators that allow cells to progress through different cell cycle phases and promote parasite proliferation during infection. In chapter 3 of this study, the results presented showed that L. major CYCA is capable …
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Studies of proteins implicated in the folding and processing of tubulin
… with what is known about orthologous proteins in Kinetoplastids and in humans, for which a standardised nomenclature has been proposed. This initial classification may guide future studies designed to elucidate biological function of specific family members. Chapter 4 contains the discussion of …
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The mRNA Cap and Discontinuous Transcription in Trypansoma brucei
<p>The protozoan parasite, Trypanosoma brucei, and other members of the phylogenetic order, Kinetoplastida, synthesize mRNA by a novel pathway that joins RNAs from physically unlinked gene segments. This results in the presence of a short non-coding RNA leader, called the miniexon, at the 5' end of …