Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"kinetic-segregation model"”.
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Protein segregation and conformation in antigen-receptor triggering: a quantitative fluorescence microscopy study
… conventional views of signal transduction. The kinetic-segregation model proposes that size-dependent exclusion of phosphatases increases net receptor phosphorylation. Rather than initiating downstream signalling autonomously, ligand binding serves to hold the receptor within …
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The Initial Events of T-Cell Activation in Realistic Model Systems
… crucial steps: the development of more realistic model systems to study those interactions, and advanced fluorescence microscopy to image and quantify the interactions in live T cells. Firstly, supported lipid bilayers (SLBs) as model surfaces for the APC membrane were improved by presenting a …
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Applying single-molecule localisation microscopy to achieve virtual optical sectioning and study T-cell activation
… This effect is further discussed in light of the kinetic-segregation model proposed for TCR triggering. Quantitative SMLM as implemented and further developed in this work offers new tools to investigate the molecular mechanisms initiating T cell activation, ultimately facilitating the discovery …