Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"kinetic-segregation"”.
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Protein segregation and conformation in antigen-receptor triggering: a quantitative fluorescence microscopy study
… conventional views of signal transduction. The kinetic-segregation model proposes that size-dependent exclusion of phosphatases increases net receptor phosphorylation. Rather than initiating downstream signalling autonomously, ligand binding serves to hold the receptor within …
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The Initial Events of T-Cell Activation in Realistic Model Systems
… small contact zones throughout, supporting the kinetic segregation model of receptor triggering. Lastly, these concepts were transferred to real cell-cell contacts. Three-dimensional imaging showed T cells also responded to ImmTAC, a bispecific immunotherapeutic, presented on APCs via small …
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Applying single-molecule localisation microscopy to achieve virtual optical sectioning and study T-cell activation
… This effect is further discussed in light of the kinetic-segregation model proposed for TCR triggering. Quantitative SMLM as implemented and further developed in this work offers new tools to investigate the molecular mechanisms initiating T cell activation, ultimately facilitating the discovery …
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Molecular Mechanisms of Lymphocyte Activation - Please Mind the Gap
… is still not fully understood, but the kinetic-segregation (KS) model of receptor triggering in T cells has been supported by several recent studies. This model proposes that the small gap between an antigen-presenting cell and an immune cell excludes large, inhibitory phosphatases, …
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Lattice gas models and simulations of epitaxial growth
… of the crystal structure, and to apply kinetic Monte Carlo (KMC) simulations for the description of the growth dynamics. The main advantage of the KMC approach is the possibility to account for atomistic details and at the same time cover MBE relevant time scales in the simulation. In …