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Showing 1 to 10 of 10 for “"kinetic resolutions"”.
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Parallel kinetic resolutions using active esters
… and practical method of achieving this. Parallel kinetic resolutions are an interesting variation on the more classical resolution methods; this method has been recently introduced to the scientific community by Vedejs and there are currently very few examples of successful parallel kinetic …
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Utilization of Rationally Designed Small Molecule Chiral Selectors in Novel Enantioselective Processes
In addition, phase transfer catalyzed biphasic kinetic resolutions of several racemic amides containing electron-deficient aromatic moieties are described. The method revolves around forming Meisenheimer adducts which are stabilized by quaternary ammonium salts in a nonpolar medium. When run in the …
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Producing Enantiopure Secondary Alcohols via a Silylation based Kinetic Resolution and a One-Pot Polishing Sequence
… one-pot polishing procedure and through kinetic resolutions via silylation and desilylation. Chapter 2 highlights how we have combined a moderately selective asymmetric reaction (either a reduction or allylation) with a kinetic resolution (via acylation or silylation) to generate …
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The Application of Catalysis based on Hydrogen Bonding and Ion-pairing Interactions to Asymmetric Minisci-type Alkylations of Azines and Iridium-Catalysed C-H Borylation.
… extension of this desymmetrisation protocol to kinetic resolutions of unsymmetrical phosphinamides. Unfortunately, poor enantioselectivity was observed with these substrates, despite their structural similarity to the substrates which had previously given excellent enantioselectivity. Chapter …
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Kinetic Resolution of N-Acyl-b-Lactams, b-Lactams, and N-Acyl-Thiolactams using Amidine-Based Catalysts
… acylation catalyst and thus can be termed as "kinetic resolutions" or KR. Considerable progress has been done in the Type I transformation, where chiral alcohols, thiols, and amines are achieved with great selectivities via asymmetric enzymatic and non-enzymatic acylation. KR of chiral acyl …
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Engineering novel tandem reactions using organometallic catalysts and (metallo)enzymes
… complexes combined with lipases catalyze dynamic kinetic resolutions. The work presented in this thesis vows to bridge the gap between chemical catalysts and en-zymes by engineering one-pot tandem reactions between these two catalytic systems, with a par-ticular interest on combining cytochrome …
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Optimisation of chemoenzymatic processes in asymmetric synthesis
… in our group focussed on baker’s yeast mediated kinetic resolution of 2-keto sulfones. The third chapter describes hydrolase-catalysed kinetic resolutions leading to a series of 3-aryl alkanoic acids. Hydrolysis of the ethyl esters with a series of hydrolases was undertaken to identify …
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Empleo de polifosfacenos como soportes enzimáticos. Preparación de compuestos enantioenriquecidos mediante procesos biocatalíticos tándem o dinámicos
… ¿-alkyl-ß-hydroxy esters through dynamic kinetic resolutions employing purified/overexpressed alcohol dehydrogenases¿. Adv. Synth. Catal. 2012, 354, 1743-1749. En el cuarto proyecto se muestra la aplicación de diferentes ¿-transaminasas como catalizadores en procesos de DKR aplicados a la …
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Development of enzyme-catalysed resolution, desymmetrisation and cascade processes. Use of lipasas, alcohol dehydrogenases and transaminases in stereoslective synthesis
… Amides by Transaminase-Mediated Dynamic Kinetic Resolutions” (ID del manuscrito: CY-ART-05-2019-001004). En el Bloque II (Capítulos 4-6) se han empleado alcohol deshidrogenasas como catalizadores en procesos de resolución cinética dinámica y desimetrización. Además, se ha llevado a cabo …
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Aplicación de flavoenzimas en síntesis orgánica
… 3-Alkyl-3,4-Dihydroisocoumarins by Dynamic Kinetic Resolutions Catalyzed by a Baeyer-Villiger Monooxygenase¿ Rioz-Martínez, A.; de Gonzalo, G.; Torres Pazmiño, D. E.; Fraaije, M. W.; Gotor, V. J. Org. Chem. 2010, 75, 2073-2076. En el Capítulo 2 se desarrolla un sistema que permite la …