Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"kinesin motor proteins"”.
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Characterization and cooperative dynamics of kinesin motor proteins in intracellular transport
… transport is typically carried out by teams of motor proteins rather than by isolated molecules, yet the rules governing multi-motor coordination remain poorly understood because motor number, spacing, and composition are difficult to control experimentally. In this dissertation, I developed …
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Regulation of chromosome attachment and dynamics by Saccharomyces cerevisiae kinetochores
… movement throughout the cell cycle. The proteins that regulate both force generation at kinetochores as well as and the cell-cycle-dependent changes in kinetochore architecture are largely unknown. The relative simplicity of centromere specification and kinetochore-microtubule attachment …
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Poxvirus A51R Proteins Directly Bind to Microtubules to Antagonize Microtubule Dynamics, Intracellular Transport, and a Cell-intrinsic Antiviral Response
… replication inside host cells. Poxvirus A51R proteins have been shown to colocalize with, and bundle, MTs, but the mechanisms of their MT interactions remained unclear. Additionally, vaccinia virus (VV), a model poxvirus, utilizes kinesin motor proteins on MTs to transport newly formed …
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Synthesis of Novel Isoprenoid Diphosphate Analogs as Chemical Tools to Investigate Protein Geranylgeranylation
<p>Many proteins require prenylation in order to be biologically functional. Some such proteins include the small Ras and Rho GTPase superfamilies, nuclear lamins A and B, and the kinesin motor proteins CENP-E and F. Prenyltransferase (PTase) inhibition is currently being explored as a possible …
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Molecular, biochemical and functional analysis of kinesins in Leishmania mexicana
… L. mexicana as a model to investigate flagellar kinesin motor proteins. Kinesins are a large superfamily (KIFs). More than 15 kinesin families were classified by phylogenetic analysis (Wickstead et al., 2006). Kinesins are motor proteins that convert the energy from ATP hydrolysis into mechanical …
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B-cyclin/CDK Regulation of Mitotic Spindle Assembly through Phosphorylation of Kinesin-5 Motors in the Budding Yeast, <italic>Saccharomyces cerevisiae</italic>
… model systems that B-type cyclin/CDK complexes, kinesin-5 motors, and the SCF<super>Cdc4</super> ubiquitin ligase are required for the separation of spindle poles and assembly of a bipolar spindle. It has been suggested that in the budding yeast,<italic> Saccharomyces cerevisiae</italic>, B-type …