Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 21 for “"kindling"”.
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Seizure development in kindling fast and kindling slow rat strains
… model is based on the susceptibility to amygdala kindling stimulation in two selectively bred rat strains. In the present study, kindling FAST and kindling SLOW rat strains were shown to exhibit differences in the development and subsequent manifestation of amygdala kindled seizures. SLOW animals …
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Re-Kindling Community Education in Neoliberal times
… approach within all of their interactions. Rekindling Community Education encourages community educators to reflect on their practice and to consider how best to advance the principles of equality and social justice though their work. This reflection should include consideration of …
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Sparks on kindling : terrorism's role in civil war onset, recurrence, and escalation
This study examines the relationship between terrorism and three major aspects of civil wars. By examining the rate of attacks and the targets of terrorism, this study explains how terrorism can serve as a macro-level indicator of instability and as a predictor of the different stages of civil …
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An Examination Of The Persistence Of Kindling, A Model For Neural Plasticity
… discussed here was to discover whether kindling is a permanent and stable state or a slowly eroding persistent state. In addition, questions concerning the relationship between retention and seizure generalization, site of stimulation, and stimulus characteristics were addressed. …
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Molecular Substrates And Neuronal Network Subserving Audiogenic Kindling In Genetically Epilepsy-Prone Rats
… the brainstem in GEPR-9s. The audiogenic seizure kindling (AGS kindling) process involves periodically repeated induction of AGS. In GEPR-9s induction of 14 or more AGS over 1-2 week period leads to a gradual increase in seizure duration, cortical epileptiform EEG, and the emergence of post-tonic …
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Effects of developmental PCB exposure on audiogenic and amygdala kindling models of seizure
… the auditory brainstem using the amygdala kindling model (a well characterized model of temporal lobe epilepsy in rodents). Two males from each of the litters described above were implanted bilaterally with electrodes in the basolateral amygdala as adults. For each animal a number of …
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Assessing the role of the hippocampus in amygdala kindled fear : an analysis of environmental habituation
Amygdala kindling is commonly used to study the mechanisms involved in epileptogenesis, with long-term amygdala kindling providing a useful model of the behavioural disturbances— such as heightened anxiety— that can occur between epileptic seizures. The purpose of this thesis was to determine …
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Skilled Behaviour and Bilateral Motor Map Expression
… movement was studied using the electrical kindling model and short-duration intracortical microstimulation (SD-ICMS). Forelimb motor map movements changed considerably from contralateral in sham-kindled rats to ipsilateral and bilateral in rats kindled for over 5 sessions. Furthermore, …
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Evaluation of Seizure Threshold as an Early Behavioral Marker of Disease Progression in the Mouse Model of Mucopolysaccharidosis IIIA
… in a difference in seizure sensitization or kindling, as early as 4 weeks. MPS IIIA mice showed significant resistance to kindling by 12 weeks. These seizure results not only demonstrate that we can record a CNS specific phenotype earlier than 20 weeks, it also suggests that neuroplasticity …
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Efeitos de crises crônicas e agudas induzidas por pentilenotetrazol sobre a hidrólise de nucleotídeos púricos em soro de ratos adultos
… aos animais controle. No modelo crônico (kindling), os animais recebiam doses inicialmente subconvulsivantes que resultam em crises progressivamente mais intensas ao longo das subseqüentes estimulações. Para descartar o efeito da injeção aguda, os ratos foram mortos 48 horas após a última …
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The gut microbiome: a contributing mechanism to the anti-seizure effect of topiramate
… seizure susceptibility in a pentylenetetrazol-kindling seizure model. Moreover, cotreatment increased the butyrate producing family Lachnospiraceae and subsequently increased the neuroprotective SCFA, butyrate in the gut microbiome. Importantly, cotreatment also resulted in an increased …
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Giving Architecture to Fire
… energy source with its warmth, light and aura, kindling feelings of truth and spirituality within us. In his poetic verses, fire was venerated by Zoroaster who led mankind to believe that there is one supreme lord that we may follow; a being that can only be known by the quest for truth (Asha). …
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Optogenetic investigation of normal and pathological rhythms in the hippocampal formation
… the essential features of traditional electrical kindling, there are distinct advantages to this approach. These experiments depend critically upon the development of novel methods for optogenetic stimulation and multi-site recording in freely moving animals. Toward this end, I have developed and …
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Development and Characterization of Pre-Clinical Epilepsy Models to Evaluate Potential Anti-Seizure Targets.
… First, we have developed a model for seizure kindling using inhaled chemo-convulsant flurothyl that can be rapidly developed and is appropriate to use in research for epileptogenesis as well as screening for potential disease modifying theories. Next, we have pharmacologically characterized …
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Novel approaches to explore mechanisms of epileptic seizures - optogenetic and chemogenetic manipulation of hippocampal circuitry
… with seizure-like afterdischarges, known as the kindling process, is traditionally induced by electrical stimulation. In paper II & III, we showed that similarly, afterdischarges could be generated by repeated optogenetic train stimulation in anaesthetized transgenic mice expressing the …
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Neuromodulation in Experimetal Animal Models of Epilepsy
… determined sensitivity for electrical amygdala kindling, which is an excellent model of temporal lobe epilepsy. Our findings support the hypothesis that these treatments can be considered as neuromodulatory: changes are induced in central nervous system function or organization as a result of …
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Chronic psychological and psychophysiological sequelae among adolescents following a traumatic bus crash
… did not find support for the neurological kindling theory. Areas of future research using psychophysiological assessment are proposed to more specifically elicit autonomic arousal. Detailed case studies of four individual response patterns are included as a heuristic for further …
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Gene therapy for epilepsy: resculpturing synaptic transmission with neuropeptides
… is not further exacerbated after electrical kindling-induced seizures, NPY gene therapy still remains a promising and novel antiepileptic treatment strategy.
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