Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 294 for “"kinase activity"”.
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Inhibition of tau kinase activity by ATP
Thesis (Ph.D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 1998.
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The Regulation of Mtorc2 Kinase Activity and Complex Integrity
… processes via activation of the</p> <p>PI3K-Akt kinase cascade. Deregulation of the growth factor-dependent PI3K-Akt</p> <p>pathway was implicated in tumorigenesis. Akt is an essential serine/threonine</p> <p>protein kinase that controls multiple physiological functions such as cell growth,</p> …
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Investigating the role of ULK1 kinase activity during autophagy
… thought to be regulated by the serine/threonine kinases ULK1/2. ULK1/2 kinase activity is required for amino acid starvation-induced and other types of autophagy. Our lab recently showed that inhibition of ULK1 with the potent compound MRT68921, results in formation of stalled autophagosomes that …
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Thymidylate kinase activity during synchronous growth of Chlorella pyrenoidosa
… pyrenoidosa have been used to determine the activity of the TMP kinase during cellular development. It was observed that the apparent enzyme activity was closely correlated with the rate of DNA biosynthesis. During the period of nuclear division, when DNA synthesis is at its maximum apparent …
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Intracellular sphingosine kinase activity as a regulator of endothelial cell inflammatory and angiogenic potential.
… in this thesis that the intracellular levels and activity of Sphingosine Kinase (SK) regulate the inflammatory potential of the endothelium and are also an important determinant of the ability of the endothelium to undergo angiogenesis. Moderate (three to fivefold) elevations in SK activity in …
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Growth regulation in the protozoan parasite Trypanosoma brucei: Evidence of tyrosine-specific protein kinase activity
… is conducted by a tyrosine-specific protein kinase. The activation of tyrosine kinases is an important step in transducing extracellular signals to a cell's interior. Until recently, protozoan organisms were thought not to possess tyrosine-specific protein kinases. This investigation …
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Development of selective peptide- and protein-based reporters of kinase activity utilizing chelation-enhanced fluorescence
Catalyzed by kinases, serine/threonine and tyrosine phosphorylation is a vital mechanism of intracellular regulation and is involved in nearly every aspect of normal, as well as aberrant, cell function. With more than 500 protein kinases present in the human genome, the need for probes that can …
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Molecular determinants regulating Bruton’s tyrosine kinase activity and their mechanism: a combined computational and experimental approach
… the unique sequence elements that regulate the activity of a protein tyrosine kinase called Bruton’s tyrosine kinase or Btk. Btk is a member of the immune signaling pathway in B-cells and is required for B-cells maturation and function.</p> <p>Lack of a three-dimensional structure of full-length …
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Hypoxia-mediated human pulmonary arterial fibroblast proliferation is dependent on p38 mitogen-activated protein kinase activity.
… not , that the stress mitogen activated protein kinase p38 MAPK is consistently activated in PAFB exposed to acute hypoxia, and is constitutively upregulated in PAFB cultured from rats exposed to chronic hypoxia (Welsh et al, 1998; Welsh et al; 2001). This response to hypoxic exposure has been …
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AMP-activated protein kinase kinase activity and phosphorylation of AMP-activated protein kinase in contracting muscle of sedentary and endurance trained rats
This study was designed to examine activity of AMP-activated protein kinase kinase (AMPKK) and AMP-activated protein kinase (AMPK) in muscles from control (C) and endurance trained (T) rats. Rats were trained 5 days/wk, 2 hr/d for 8 wks at a final intensity of 32 m/min up a 15% grade with 30 second …
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mTOR Signaling in Cellular Growth and Skeletal Muscle Maturation
A Serine/Threonine kinase, mTOR, is a cellular target of rapamycin and plays a role in cellular growth and proliferation by regulating translation through the phosphorylation of 4E-BP1 and S6K. Here, I investigated the function of mTOR for the activation of newly found S6K1 homologue, S6K2, and for …
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The Role of Tak1 In Pancreatic Cancer Development
… tumor tissues. We demonstrated that the elevated activity of TAK1 is caused by its binding partner TAB1. Knocking down of TAK1 in pancreatic cancer cells with RNAi technique resulted in cell apoptosis and significantly reduces the size of tumors in mice and made a chemotherapy drug more potent. …
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Leishmania CRK3:CYC6 cyclin-dependent kinase as a drug target
… its cell cycle. There are 11 cyclin dependent kinases (CDKs) and 11 cyclins present in the Leishmania genome reflecting the complexity of cell cycle control in this parasite, perhaps due to the requirement for synchronisation with the life cycle. Leishmania mexicana CRK3, a cdc2-related …
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Signaling By Protease-Activated Receptors in Gastrointestinal Smooth Muscle
… PAR2 agonists stimulated PI hydrolysis and Rho kinase activity and inhibited cAMP formation. PAR1-stimulated PI hydrolysis was abolished in cells expressing Gαq minigene, but was not affected in cells expressing Gαi minigene or in cells treated with pertussis toxin (PTx). PAR2-stimulated PI …
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The molecular and biochemical characterization of cell cycle regulators in Pisum sativum
… these proteins copurify with a histone H1 kinase activity by p13$\sp{suc1}$-Sepharose affinity chromatography. p13$\sp{suc1}$-associated histone H1 kinase activity is elevated and a set of endogenous proteins is phosphorylated specifically at the S and M phases. Cell cycle changes in the …
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Mutagenic Studies of RdoA, a Eukaryotic-Like SER/THR Protein Kinase in Salmonella Enterica Serovar Typhimurium
… is a eukaryotic-like serine/threonine protein kinase found in Salmonella typhimurium. It is a downstream effector of the Cpx stress response pathway and has been phenotypically characterized to have a functional role in flagellin phase variation and long-term bacterial survivability. …
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Beteiligung der Phospholipase D an der Regulation der Synthese von Phosphatidylinositol-4,5-bisphosphat durch Arf- und Rho-GTPasen
… to stimulate phosphatidylinositol-4-phosphate-5-kinase (PIP-5-kinase) activity in vitro. In the present study, we have examined wether PLD affects the synthesis of phosphatidylinositol 4,5-bisphosphate (PIP2) by PIP-5-kinase. Overexpression of PLD isoforms in HEK-293 cells led to an increase in …
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Characterization and localization of a cyclic AMP dependant protein kinase from Dictyostelium discoideum
… regulated cyclic AMP-dependent protein kinase has been recently reported in Dictyostelium discoideum. This report describes some of the physical and kinetic properties of the cAMP-dependent holoenzyme and its subunits. Gel filtration data suggests a holoenzyme Mr of 170,000-190,000, and …
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