Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"kidney organoid"”.
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3D KIDNEY ORGANOIDS AS A PLATFORM FOR INVESTIGATING MONOGENIC DISEASES AND GENE THERAPY APPROACHES
… pluripotent stem cells (iPSCs) to generate kidney organoids as a 3D model of rare inherited kidney diseases. Human kidney organoids are an invaluable platform for studying renal pathophysiology, developing cell-based therapies, and testing novel therapeutic approaches. We generated and …
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Leveraging cellular models of polycystic kidney disease for mechanistic discovery and therapeutic development
Polycystic kidney disease (PKD) is a life-threatening disorder characterized by the progressive expansion of fluid-filled cysts originating from kidney tubules. As the leading monogenic cause of renal failure, PKD affects 1 in ~1,000 people with 50% of patients meeting criteria for end-stage renal …
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Autologous Proliferative and Immunobiological Modelling of Patient-Derived Clear Cell Renal Cell Carcinoma and Kidney Organoids
… in vitro using expanded patient-derived ccRCC, kidney and peripheral blood tissues. However, patient-derived ccRCC organoids (PDO-ccRCC) proliferate poorly ex vivo and the consequences of expansion on healthy kidney organoid controls (PDO-KO) and autologous T cell expansion are poorly …
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Using human induced pluripotent stem cells to model cystinosis
… lysosomes in most cells of the body, however the kidney is the main organ affected. For poorly understood reasons, renal proximal tubule (PT) cells lose their functionality and degenerate in cystinosis, forming a characteristic “swanneck” lesion that leads to kidney failure before 10 years of age. …
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Kidney tubulogenesis in human renal organoids: an investigation into the contribution of the microtubule-associated protein DCDC2
During early human kidney development, the cells of the metanephric mesenchyme repeatedly undergo a mesenchymal to epithelial transition (MET). This forms an initial tube which subsequently extends into the nephrons, which are the functional unit of the kidney. When kidney nephrons are lost due to …