Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 38 for “"kidney diseases"”.
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A Non-Canonical Function for NLRP3 and AIM2 in Kidney Diseases
… such as tubular epithelial cells (TEC) in the kidney. The central hypothesis of this thesis is that NLRP3 and AIM2 regulate host response to renal injury in the kidney. Primary mouse TEC lacking Nlrp3 displayed reduced caspase-8 activation downstream of the tumor necrosis factor (TNF) receptor …
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Impact of minerals in Chinese medicinal herbs and decoctions on kidney function
Kidney function or renal function is essential and depends on the ability of the kidneys to filter the blood. Millions of people around the world suffer from kidney diseases, and these patients will eventually need a form of renal replacement therapy: dialysis or transplantation. Dialysis and …
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Hospital Inpatient Cost And Discharge Status Of Diabetes And Its Complications In The U.S.
… cohort, peripheral lower-extremity (PLE) diseases-related hospitalization cohort, kidney diseases-related hospitalization cohort, and coronary atherosclerosis-related hospitalization cohort. In each cohort, hospitalization cost was calculated by multiplication of the total hospitalization …
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Evaluation of genetic variants for Type 2 diabetes associated kidney disease in African Americans
End-stage kidney disease (ESKD) is a significant public health problem in the U.S., disproportionately affecting African Americans (AAs; 1,003 per million/year) at 3.3-fold higher incidence rate than European Americans (301 per million/year), and 2-fold higher than Native Americans (499 per …
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The Role of Daam1 In Kidney Development
<p>Kidneys, like most organs in our bodies, consist of a network of epithelial tubules. Kidney tubules are called nephrons, and their morphology is important for kidney function. Nephrons develop from mesodermally derived aggregates of progenitor cells. The nephric progenitors organize into nephric …
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The Role of Daam1 In Kidney Development
<p>Kidneys, like most organs in our bodies, consist of a network of epithelial tubules. Kidney tubules are called nephrons, and their morphology is important for kidney function. Nephrons develop from mesodermally derived aggregates of progenitor cells. The nephric progenitors organize into nephric …
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Chalcone derivatives from pyrrole-2-aldehyde
… therapeutic action in the treatment of chronic kidney diseases, diseases of the eye, and rheumatoid diseases, such as bursitis and osteoarthritis. Treatment of chalcones with sulfuric acids to obtain α-ketosulfones, used as chemotherapeutic agents, has been under investigation and useful results …
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Complications of percutaneous native kidney biopsies in adults in low and middle-income countries: A Systematic review and meta-analysis
Introduction: Kidney biopsy supports diagnoses, choice of treatment and prognostication in management of kidney diseases. Complications associated with this procedure varies among countries depending on several clinical and technical factors. This Systematic review and meta-analysis aims to report …
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Liquid Crystal Mediated Bioassay for Protein Detection
… samples is a standard procedure for diagnosis of kidney problems and prognosis of patients with chronic kidney diseases (CKDs). This PhD work developed a HSA assay by incorporating a thin layer of liquid crystals (LCs) as a readout system such that the presence of HSA in urine samples can be …
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Modelling Human Glomerulosclerosis in vitro
Glomerulosclerosis is a feature of many chronic kidney diseases. Glomeruli are composed of glomerular endothelial cells (GECs), podocytes (PODs) and mesangial cells (MCs), and dysregulation in the interaction between these cell types results in glomerulosclerosis. This is characterised by excessive …
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Infrared spectrophotometric analysis of serum triglycerides
… been claimed to be a major cause of numerous diseases and illnesses. Fredrickson and his associates (7, 15) have introduced a system for classifying hyperlipidemia and in all classes elevated triglycerides is a major laboratory finding. Disorders include obesity, diabetes, pancreatitis, …
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An Account of Chemical and Mechanical Regulation of TRPC6 Channels in Podocytes
… implicated in certain forms of proteinuric kidney disease. TRPC6 channels are polymodal and can be activated by either chemical or mechanical stimuli. Chemical stimulation is mediated by surface-expressed receptors, and the roles of angiotensin II type 1 receptors (AT1R), insulin receptors, …
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CELLULAR AND MOLECULAR MECHANISMS OF AT2R MEDIATED ANTI-PROTEINURIC ACTIVITY
… and specific biomarker of and a cause for kidney diseases. Immediate effects upon consumption of high sodium (4%) diet (HSD) on the expression of protein endocytic receptor megalin and its impact on proteinuria, particularly in obesity is not known. There are indications suggesting the …
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Clinical Presentation and Histopathological Description of the Spectrum of Renal Diseases in HIV Infected Adults Presenting With Renal Insufficiency at the University Teaching Hospital,Lusaka Zambia
Introduction: The spectrum of renal diseases in HIV infected adults undergoing biopsy is vast. Previous studies have indicated that HIV-associated nephropathy (HIVAN) is the commonest diagnosis in HIV-infected patients presenting with renal insufficiency. More than 90% of patients with HIVAN are …
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Clinical Presentation and Histopathological Description of the Spectrum of Renal Diseases in HIV Infected Adults Presenting With Renal Insufficiency at the University Teaching Hospital,Lusaka Zambia
Introduction: The spectrum of renal diseases in HIV infected adults undergoing biopsy is vast. Previous studies have indicated that HIV-associated nephropathy (HIVAN) is the commonest diagnosis in HIV-infected patients presenting with renal insufficiency. More than 90% of patients with HIVAN are …
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The spectrum of HIV-related kidney disease in South Africa
The spectrum of HIV-related kidney disease in South Africa Associate Professor Nicola Wearne Background: HIV is associated with a spectrum of kidney diseases, including HIV-associated nephropathy (HIVAN), opportunistic infections, including tuberculosis (TB), and adverse effects of drugs and immune …
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Characteristics and allocation outcomes of patients assessed for the renal replacement therapy at Groote Schuur Hospital (2008-2012)
End Stage Kidney Disease (ESKD) is a global public health problem with an enormous economic burden. In resource limited settings like South Africa management of End Stage Kidney Diseases is rationed to the most transplantable candidates. Racial and socio-economic inequalities in selecting …
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IDENTIFICAZIONE DI NUOVI BIOMARKER E METODI ANALITICI INNOVATIVI IN PATOLOGIA CLINICA VETERINARIA
… (ET-1). Hypertension usually is secondary to diseases that indirectly could affect the systemic pressure, mainly renal and heart diseases. Homocysteine appears increased in dogs with both heart and kidney disease, but the clinical usefulness and the sensibility is not enough for positive …
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3D KIDNEY ORGANOIDS AS A PLATFORM FOR INVESTIGATING MONOGENIC DISEASES AND GENE THERAPY APPROACHES
… pluripotent stem cells (iPSCs) to generate kidney organoids as a 3D model of rare inherited kidney diseases. Human kidney organoids are an invaluable platform for studying renal pathophysiology, developing cell-based therapies, and testing novel therapeutic approaches. We generated and …
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