Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"kidney damage"”.
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Cardiovascular effects of lead and mercury and their mixtures in rats
… focused on the exploration of oxidative stress, kidney function and damage, and global DNA methylation as potential mechanisms of action for the development of elevated blood pressure. Results for lead showed an increase in oxidative stress but not mercury. While only lead was associated with …
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Dietary Control of Cystinuria in Maned Wolves (Chrysocyon Brachyurus)
… and ultimately causing bladder rupture or kidney damage. Treatments include medical management and dietary modification. Test diets differing only in levels of cystine were fed to 15 maned wolves in a cross-over design. Apparent digestibility calculations suggest the diets were well …
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O efeito antioxidante da quercetina em doenças crônicas não transmissíveis : uma revisão de literatura.
… cancer, chronic respiratory diseases, liver and kidney damage, among others. They are from multifactorial etiology and share many of these risk factors, which may be behavioral or genetic. Studies have shown that some of the risk factors can be reduced through changes in daily habits. Therefore, …
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Effects of magnesium deficiency on urinary glycoproteins in the rat
… until after the first week, when irreversible kidney damage is initiated. Control animals whose weight ga:m was restricted to 32% 0£ normal excreted less of Fraction I per day. Amino acid patterns of both fractions from all groups were similar, but differed from those reported for human and …
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A Mutation in Alk6b Causes Impaired Germ Cell Differentation and Testicular Germ Cell Tumors in Zebrafish
… effects including hearing loss, infertility and kidney damage. We identified a zebrafish mutant line with a high incidence of GCT during a forward genetic screen to identify cancer susceptibility loci. Homozygous adult males develop tumors consisting of undifferentiated spermatogonia by 4 months …
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Establishing a Model of Organ regeneration in the Adult Mammal: Age Dependence and the Utility of Non-Invasive Imaging
… response. Most strikingly, evidence of chronic kidney damage was found. This failure to recover the high-volume function of the bladder was not reversed by local administration of adipose derived stem cells at the time of STC. These studies establish an age-dependent model of mammalian organ …
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Compensatory renal hypertrophy, mitochondria and redox status
… mass occurs in humans during aging and severe kidney damage from diseases, injuries, infections and congenital conditions and after nephrectomy. Nephrectomy, or surgical removal of a kidney or a section of a kidney, is performed for treatment of unilateral secondary renal cancer, infections and …
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A murine model of developmental programming of atherosclerosis
… of atherosclerosis and evidence of liver and kidney damage as compared with their apoE+/-pat counterparts. In contrast, at day 21 of life apoE-/-KO and apoE+/-mat pups showed lower total cholesterol and triglyceride levels than apoE+/+WT or apoE+/-pat litters. \r\nStudies in liver tissue from …
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An intelligent system approach for predicting the risk of heart failure
… heart valve problems, pulmonary hypertension, kidney damage, liver damage, malnutrition etc. According to the World Health Organization (WHO), the number one cause of death in cardiovascular diseases (CVD) is estimated at 17.9 million a year, which accounts for 31% of all deaths worldwide. The …
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4D flow and displacement sensitive MR imaging of upper arm arterio-venous connections for haemodialysis
Chronic Kidney Disease (CKD) is a disease that causes kidney damage, often leading to the patient requiring haemodialysis treatment. Haemodialysis treatment requires a vascular access method, commonly Arteriovenous (AV) fistulae and grafts. These access methods must be regularly assessed to ensure …
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Vascular Mechanisms of Rhabdomyolysis-induced Acute Kidney Injury
… into circulation is the primary cause of kidney injury. Myoglobin causes direct kidney injury as well as severe renal vasoconstriction. An increase in renal vascular resistance (RVR) results in renal blood flow (RBF) and glomerular filtration rate (GFR) reduction, tubular injury, and acute …
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Genetic variability and cadmium metabolism and toxicity
… and shellfish. Adverse health effects on kidney and bone at low-level environmental Cd exposure are well-documented in adults. There is considerable inter-individual variation in both metabolism (toxicokinetics) and toxicity (toxicodynamics) of Cd. This may be due to genetic factors. The …
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Caracterización clínico - epidemiológica de enfermedad renal crónica en adultos de 30 - 50 años en Unidad de Salud El Paisnal (julio - agosto 2025)
… de IVU a repetición en un 17%. Chronic kidney disease (CKD) represents a growing public health problem, particularly in rural communities such as El Paisnal, where it has been identified as one of the leading causes of mortality among adults. This research aimed to carry out a …
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Mechanisms of Neutrophil Exhaustion and Resolution
… therapeutic effects with alleviated lung and kidney damage. We also observed TRAM-deficient neutrophil-mediated resolving memory propagation in vitro to promote resolving features of neutrophils, monocytes, and T cells, as well as to strengthen endothelial cell barrier function. In terms of …
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Targeting epithelial senescence to augment renal repair
… injury is essential for maintaining normal kidney function and is vital to the health of millions of patients every year. Maladaptive repair occurs when kidneys fail to return to normal levels of function following an injury and have excessive fibrosis and resulting organ impairment. …
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Using agricultural wastes to treat lead-contaminated water in Western Australia
… Pb (II) is a heavy metal that causes significant damage in the human body. Drinking lead-contaminated water even at low concentrations may cause lifethreatening conditions such as cancer, kidney damage, brain damage, and liver problems (El-Said 2010). Therefore, it is necessary to remove lead from …
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Identification of Effectors of Synergistic Lethality in Candida albicans-Staphylococcus aureus Polymicrobial Intra-abdominal Infection
… significant increases in biomarkers of liver and kidney damage during coinfection and determined that functional toxin was required for morbidity and mortality. We next sought to determine the candidal effector(s) mediating this enhanced virulence by employing an unbiased screening approach. C. …
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Harnessing Systems Bioengineering Approaches to Study Microbe-Microbe and Host-Microbe Interactions in Health and Disease
… if unchecked, ultimately resulting in end-organ damage (especially lung and kidney damage), as with the severe cases of sepsis and COVID-19. In our work, we developed a combined infection-inflammation NET-array system integrated with a live imaging assay to quantify the spatiotemporal dynamics of …
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Factors Regulating the Intrarenal Renin-Angiotensin System and Renal Damage During Aging
… both strains develop insulin resistance and kidney damage (proteinuria) during aging with the SD rats also developing an increase in blood pressure. Long-term (1 year) systemic RAS blockade with the angiotensin (Ang) II type 1 (AT1) receptor antagonist L-158,809 in the F344 rats prevented the …