Global ETD Search
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Showing 1 to 2 of 2 for “"ketoamides"”.
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New chemical and biosynthetic methodologies for the study of lanthipeptides
… after leader peptide removal results in α-ketoamides that site-specifically react with an aminooxy-derivatized alkyne or fluorophore. The fluorescently-modified lantibiotics were added to bacteria, and their cellular localization was visualized by confocal fluorescence microscopy as a means …
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Pin1 Inhibitors: Towards Understanding the Enzymatic Mechanism
An important role of Pin1 is to catalyze the cis-trans isomerization of pSer/Thr-Pro bonds; as such, it plays an important role in many cellular events through the effects of conformational change on the function of its biological substrates, including Cdc25, c-Jun, and p53. The expression of Pin1 …