Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 38 for “"keratitis"”.
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Role of the NLRP3 Inflammasome in bacterial keratitis
… inflammasome in the pathogenesis of bacterial keratitis is not clearly understood. Macrophages play an important role in inflammation and infection and are known to produce the NLRP3 inflammasome. The NLRP3 inflammasome produces IL-1β a key pro-inflammatory mediator. The phenomenon of …
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Topical Nanoparticulate Formulation of Drugs for Ocular Keratitis
… in the treatment of ocular viral/bacterial keratitis. PART 1: Poly(D,L-lactic-co-glycolic acid) (PLGA) nanoparticles (NP) of dipeptide monoester prodrugs of ganciclovir (GCV) including L-Val-L-Val-GCV (LLGCV), L-Val-D-Val-GCV (LDGCV), D-Val-L-Val-GCV (DLGCV) were formulated and dispersed in …
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Epidemiology and microbiology of microbial keratitis in Queensland, Australia
Aim: Guide practitioners’ management of microbial keratitis (MK) by providing epidemiological information to define the disease and trends of MK in Queensland, Australia. Methods: This project studies MK through two databases to define and analyse the disease in Queensland. Databases used were the …
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The Effect of Orally Administered Butylated Hydroxytoluene on Herpes Simplex Keratitis
<p>Some studies have reported in vitro inactivation of membrane enveloped viruses by Butylated hydroxytoluene (BHT). This study investigates the effect of orally administered BHT on primary infections of Herpes simplex virus (HSV) using rabbit corneas as the assay system. </p> <p>Assigned levels of …
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Acanthamoeba spp. Secrete a Mannose-Induced Protein that Correlates with Ability to Cause Acanthamoeba Keratitis
… corneal inflammation known as Acanthamoeba keratitis. The pathogenic cascade of Acanthamoeba keratitis begins when Acanthamoebae bind to mannose expressed on traumatized corneas. Published reports indicate that mannose is upregulated on the corneal surface during wound healing. Experiments …
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Establishing an ex vivo model of acanthamoeba keratitis and investigating the phenotypic similarities between the protozoan acanthamoeba and human macrophages
… infection of the cornea called Acanthamoeba keratitis (AK) in immunocompetent individuals, and a fatal granulomatous encephalitis in the immunocompromised. In this study, an ex vivo model of AK was developed to better understand the pathophysiological processes that occur in this disease. The …
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Sustained release nanoparticles containing acyclovir prodrugs for ocular herpes simplex keratitis and characterization of folate transport proteins in a corneal epithelial cell line
… characterized for the treatment of ocular herpes keratitis. L-valine-Lvaline- ACV and L-valine-D-valine-ACV were determined to be optimum in terms of enzymatic stability, uptake and cytotoxicity. Uptake and docking results indicated that Lvaline in the terminal position increases the affinity of …
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Survey of recent methods of diagnosis and treatment of interstitial keratitis, and an analysis of the results of treatment in a series of 105 cases
Interstitial keratitis was for a long time regarded as a definite disease affecting the eye, and it was not until 1863 that Jonathan Hutchinson, in his "Clinical Memoirs ", established it as being directly due to Inherited Syphilis. In this work Hutchinson mentions that Dr Mackenzie had already …
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Μελέτη των ιστολογικών βλαβών του κερατοειδούς από και τα συστατικά της slime - GLP και LPS
… the inducted lesions were studied. Experimental keratitis was induced (a) by a single intracorneal injection of live bacteria of the P.a. prototype strain PAC-IR (20-30 cell/per injection), (b) by a single injection of 100μg slime-GLP and (c) by a single injection of 2μg LPS. Slime-GLP and LPS …
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Exploring the potential of UVC in treating superficial corneal infections
Microbial Keratitis (MK) is an acute, sight-threatening corneal infection. First line treatment for bacterial keratitis (BK) comprises topical antibiotics, either a dual therapy of fortified cephalosporin and aminoglycoside, or single fluoroquinolone therapy. Surveys describe increasing bacterial …
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Comparative efficacy of azole compounds targeting sterol 14-demethylase against multiple isolates of Acanthamoeba castellanii and polyphaga
… spp. in immunocompetent humans is Acanthamoeba keratitis a severe infection of the eye that has increased in prevalence mainly due to the increase in the use of contact lenses. Current methods of treatment for Acanthamoeba keratitis are sporadic in effectiveness and no standard treatment regime …
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The effects of Nd:YAG laser cyclophotocoagulation on corneal sensitivity, intraocular pressure, aqueous tear production and corneal nerve morphology in the canine eye
… ulcerations may be a form of neurotrophic keratitis due to laser-induced damage to corneal innervation. Fifteen clinically normal dogs had the neodymium:yttrium aluminum garnet(Nd:YAG) laser cyclophotocoagulation performed on the left eye. Each treated eye received 100 Joules of laser …
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Determining the beneficial properties of bovine amniotic membrane and its efficacy as a therapy for corneal healing
Corneal ulceration, or ulcerative keratitis, is one of the most common ocular diseases observed in dogs and horses, particularly after trauma. Superficial corneal ulcers can heal without complications in a noninfected environment, but severe ulcerative keratitis can progress rapidly and lead to …
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The Transcriptional Regulation Of Flagellin-Induced Innate Protection Of The Cornea: Role Of Irf1 And Atf3
… markedly increased the severity of P. aeruginosa keratitis and significantly attenuated flagellin-elicited protection compared to WT controls at 3 dpi. CXCL10 neutralization in the cornea of WT mice displayed similar pathogenesis to that of IRF1-/- mice. To understand the regulation of CXCL10 …
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AMNIOTIC MEMBRANE TRANSPLANTATION FOR OCULAR SURFACE RECONSTRUCTION IN VETERINARY MEDICINE
… deficiency, bullous keratopathy, infectious keratitis, Stevens Johnson syndrome, melting ulcers, scleral melt and band keratopathy. In veterinary ophthalmology AMT has been described for the treatment of ocular surface neoplasia, bullous keratopaty, melting ulcers, symblepharon, …
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Fully automated computer system for diagnosis of corneal diseases. Development of image processing technologies for the diagnosis of Acanthamoeba and Fusarium diseases in confocal microscopy images
… in the diagnosis of Acanthamoeba and fungal keratitis which considered sight-threatening corneal diseases. However, it can be difficult to find and train confocal microscopy graders to accurately detect Acanthamoeba cysts and fungal filaments in the images. Use of an automated system could …
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Fully automated computer system for diagnosis of corneal diseases. Development of image processing technologies for the diagnosis of Acanthamoeba and Fusarium diseases in confocal microscopy images
… in the diagnosis of Acanthamoeba and fungal keratitis which considered sight-threatening corneal diseases. However, it can be difficult to find and train confocal microscopy graders to accurately detect Acanthamoeba cysts and fungal filaments in the images. Use of an automated system could …
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Elucidating Pseudomonas aeruginosa virulence gene regulation by the ribbon-helix-helix transcription factor AmrZ
… patients, including endocarditis, microbial keratitis of the eye, pneumonia, urinary tract infections, and chronic lung infection in patients with cystic fibrosis. The underlying cause of the severity of these infections is due in part to the arsenal of virulence factors <italic>P. …
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Perfil de resistência aos antimicrobianos frente à pseudomonas aeruginosa isoladas de afecções oftálmicas em diversas espécies: revisão sistemática
… bears. The most prevalent disease was ulcerative keratitis. The antibiotic classes with the lowest percentages of resistance were to aminoglycosides (amikacin, gentamicin and tobramycin), to fluoroquinolones (levofloxacin, ciprofloxacin, nofloxacin and gatifloxacin) and to Imipenem. In the …
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Preparation And Evaluation Of Valacyclovir Hydrochloride Ocular Inserts By Hot Melt Extrusion Technique
… Acyclovir, which is used in treatment of ocular keratitis and HSV infections. The bioavailability of the prodrug is better than the acyclovir and it is proved to permeate extensively through the corneal barrier. The polymer of choice was Klucel® Pharm MF and JF grades for the study. To optimize …
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