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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

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Showing 1 to 20 of 184 for “"keratinocytes"”.

  1. Mechanisms Underlying Alcohol-Mediated Cellular Injury In Esophageal Keratinocytes

    Modayur Chandramouleeswaran, Prasanna Venkata Ramanan2019

    … and cytoprotective mechanisms in esophageal keratinocytes. Here we utilize RNA-Seq to identify dramatic decrease in genes and pathways associated with DNA repair and Mitochondria in alcohol exposed human esophageal keratinocytes. Alcohol caused significant structural damage to mitochondria …

    penn Repository record

  2. RegulationofGap Junction Protein,Connexins in Immortalized Human Keratinocytes Cells(HaCaTcells)

    김, 병철2011

    Intercellular communication for function of cells and tissues is very important as the intracellular communication system. Gap junctions are ordered arrays of intercellular plasma membrane channels that directly link the cytosols of two adjoining cells. Gap junctional intercelluar communication …

    ajou Repository record

  3. Local and Systemic Consequences of Reducing Notch Signaling in Skin Keratinocytes

    Demehri, Shadmehr2010

    … mammalian skin. Removal of Notch alleles in skin keratinocytes has been associated with an array of phenotypes with varying severity based on the identity and number of remaining Notch receptors. Phenotypes include carcinogenesis: in the case of Notch1 loss), transformation of hair follicles to …

    wustl Repository record

  4. Gene transfer of keratinocytes with a human Factor XIII - plasmid construct

    Horváth, Laura

    … the transient liposomal transfection of human keratinocytes with the gene for clotting factor XIII and the analysis of the protein expression for a future in vivo use for wound healing. Human keratinocytes were cultured in vitro with serum free medium. At 80% confluence liposomal transfection …

    freiburg-diss Repository record

  5. Matrix metalloproteinases -21 and -26 in keratinocytes and in keratinocyte-derived cancers

    Ahokas, KatjaHelsingin yliopisto2005

    helsinki Repository record

  6. Mechanistic assessment of fibroblast growth factor receptor signaling and function in keratinocytes

    Rauschendorfer, Theresa; id_orcid0000-0002-2768-6618ETH Zurich2021

    ethz Repository record

  7. Molecular Dynamics of p21 and Fluorescent Sphingomyelin in Keratinocytes Exposed to UVB

    Fraser, Tyler Malcolm2018

    … and location of the damage marker p21 within keratinocytes that were incubated in sphingomyelin (SM) and later exposed to UV. Confocal microscopy and automated image processing provided the tools to assess large populations of keratinocytes in the effort to accurately identify the …

    calpoly Repository record

  8. Frcutose-1,6-diphosphate inhibits Prostaglandin E2 production in UVB-irradiated HaCat Keratinocytes

    윤, 형영2011

    Master

    ajou Repository record

  9. Estrogen receptor involvement in the response of human keratinocytes to ultraviolet B irradiation

    Farrington, Daphne L.2014

    … growth, senescence, and apoptosis to protect keratinocytes. Additional signaling due to E2-activation of the estrogen receptor may provide back-up or redundant pathways in response to UVB.

    iupui Repository record

  10. The Characterization of Cx31 in Keratinocytes and its Link to Erythrokeratodermia Variabilis et Progressiva

    Au, AkinaThe University of Western Ontario2018

    … Cx26, Cx30 and Cx43 in rat epidermal keratinocytes. We demonstrated that the apparent half-life of Cx31 was extended compared to Cx43, and that Cx31 gap junctions persisted longer at the cell surface. In REKs, Cx31 gap junctions were dynamic and the ablation of Cx43 did not prevent …

    uwo Repository record

  11. Transcriptomic and Proteomic Studies of Intercellular Communication Between Melanocytes and Keratinocytes in Human Skin

    Spitz-Becker, Gabriella Stephanne

    … epithelium composed of multiple cell types. Keratinocytes are the most prevalent cells in the epidermis and provide the barrier function of the skin. Interspersed amongst the keratinocytes in the basal layer of the epidermis are melanocytes, the pigment producing cells of the epidermis. …

    rockefeller Repository record

  12. Effects of arsenic and UVB radiation on induction of cyclin D1 in human keratinocytes.

    Gonzalez, Julian

    … vitro model system using Normal Human Epidermal Keratinocytes (NHEK) to identify the effect of arsenic and UVB on humans and whether they work synergistically. We find that although both cause induction of cyclin D1, culturing cells with both co-mutagens does not lead to a potentiated effect. …

    cuny Repository record

  13. The Use of Sphingomyelin to Protect Against UV Induced DNA Damage in Human Keratinocytes

    Campbell, Kevin2015

    … present the use of SM for UV protection of human keratinocytes (KRTs) to prevent DNA mutations that result from UV exposure. In particular, analysis of the expression of DNA damage biomarkers p21 and p53 was done to determine the potential of SM to prevent DNA damage associated with UV exposure. …

    calpoly Repository record

  14. An examination of the role of IFI16 in detecting viral DNA in human immortalised keratinocytes

    O'Hare, Craig, Unterholzner, LeonieLancaster University2017

    … and DNA virus infection in human immortalised keratinocytes (HaCaT). The cGAS-STING pathway was examined in IFI16(-/-) HaCaT cell lines to conclusively determine the contribution of IFI16 to DNA sensing. IFI16(-/-) HaCaT cell lines produced drastically reduced levels of interferon-b, …

    lancaster Repository record

  15. Assessing the Photoprotective Effects of Fluorescent Sphingomyelin Against UVB Induced DNA Damage in Human Keratinocytes

    Kandell, Rebecca Marie2018

    … potential by reducing p21 and p53 levels in keratinocytes (KRTs) after UV radiation [13], [14]. This thesis aims to expand on past BSM research by exploring the mechanism for photoprotection. Normally, sphingomyelin (SM) is metabolically degraded to ceramide which then leads to cell apoptosis …

    calpoly Repository record

  16. Alteration of differentiation and growth of normal human epidermal keratinocytes by benzo[a]pyrene and arsenic

    Perez, Damon Scott, author, Campain, Julie, advisor, Yang, Raymond Shih-hsien, 1940-, advisor, Legare, Marie E., committee member, Fox, Michael, committee member, Ranu, Rajinder S., committee memberColorado State University. Libraries2005

    Normal human epidermal keratinocytes (NHEK) were chosen as an in vitro model for mechanistic studies into how altered regulation of differentiation may play a role in the malignant transformation process in human cells. Initially, the cytotoxicity of four petroleum-derived hydrocarbons …

    colostate Repository record

  17. Characterizing the motogenic response of human keratinocytes to epidermal growth factor and transforming growth factor-alpha

    Rodgers, Stephen DMassachusetts Institute of Technology1996

    Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering, 1996.

    mit Repository record

  18. Mechanisms of epigenetic regulation in epidermal keratinocytes during skin development. Role of p63 transcription factor in the establishment of lineage-specific gene expression programs in keratinocytes via regulation of nuclear envelope-associated genes and Polycomb chromatin remodelling factors.

    Rapisarda, ValentinaUniversity of Bradford2015

    … Here we show that in p63-null mice about 32% of keratinocytes showed altered nuclear morphology. Alterations in the nuclear shape were accompanied by decreased expression of nuclear lamins (Lamin A/C and Lamin B1), proteins of the LINC complex (Sun-1, nesprin-2/3) and Plectin. Plectin links …

    bradford Repository record

  19. RBPjk-Independent, NICD-Dependent Signals in Rbpj-/- Hair Follicle Keratinocytes Cause a Milder Phenotype in RBPjcKO Animals

    Turkoz, Mustafa2014

    … signals in the Rbpj-/- hair follicle keratinocytes causing a milder phenotype in RBPjcKO animals. Future experiments will interrogate whether RBPjk-independent NICD activity directly generates a different transcriptional response or affects other signaling pathways.</p>

    wustl Repository record

  20. Induction of hair follicles using neonatal mouse dermis and human keratinocytes: relevance for improved burn wound treatments

    Malise, Thudzelani Takalani AustinDivision of Cell Biology2020

    … requires the interaction between epithelial (keratinocytes) and mesenchyme cells. Attempts to recapitulate the process of hair induction in wounded skin in vitrousing human cells have to date been unsuccessful. The aim of this project is to attempt to elicit the early steps of hair follicle …

    cape-town Repository record

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