Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"keratinocyte proliferation"”.
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Stochasticity and order: studies of keratinocyte proliferation
… The wide range of colony sizes in cultured human keratinocytes has been taken to support this hypothesis. Contrary to this model, researchers using genetic lineage tracing in mouse epidermis have inferred a single progenitor population for homeostasis, and a quiescent stem cell population …
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Longitudinal Keratinocyte Proliferation Induced by Human Papillomavirus 16E6 and NFX1-123 Partnership
… we quantify the growth rates of 16E6-expressing keratinocytes with endogenous or overexpressed NFX1-123 (16E6/vec and 16E6/FN123, respectively) levels by measuring population doublings and interrogate whether proteome expression changes occur early or late in longitudinal growth assays that began …
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Mechanisms of Epidermal Growth Factor Receptor Regulation of Epidermal Proliferation and Skin Tumorigenesis in Response to Ultraviolet Irradiation.
… signal transduction increases normal keratinocyte proliferation and proliferation in response to ultraviolet (UV) irradiation, resulting in increased skin tumor growth. The mechanisms of EGFR’s mitogenic effects on keratinocytes were examined using EGFR null keratinocytes and an EGFR …
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The role of bone morphogenetic protein signalling in the control of skin repair after wounding. Cellular and molecular mechanisms of cutaneous wound healing mediated by bone morphogenetic proteins and their antagonist Noggin.
… and postnatal remodelling by regulating proliferation, differentiation and apoptosis. However, their role in wound healing remains unclear. To study this, transgenic mice overexpressing Smad1 (K14-caSmad1) or the BMP antagonist Noggin (K14-Noggin) were utilised, together with human and …
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Pathological meprin alpha expression as a driver of inflammatory skin disease
… consists of distinct layers composed of keratinocytes at different stages of terminal differentiation. This process is orchestrated by a network of epidermal proteases, which require tight regulation. Any changes to any of these factors could lead to dysregulation of the epidermal …
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An alginate hydrogel matrix for the localised delivery of a fibroblast/ keratinocyte co-culture to expedite wound healing
… in calcium-alginate hydrogel and culture of keratinocytes on the surface. Initially, the use of 5% and 2% w/v alginate hydrogels were investigated. Both scaffolds maintained fibroblast viability for at least 150 days encapsulation and caused reversible mitotic and catabolic inhibition, as …
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Melanocyte proliferation in wounded skin in vitro: a histological and immunohistochemical analysis
… restoration of effective skin barrier function, keratinocytes must proliferate and migrate to cover the gap created by the wound in an efficient and timeous manner. Melanocytes are not thought to actively participate in wound repair and closure, since they are primarily responsible for …
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Regulation of apoptosis and desmosomes by RhoE
… of cell types, the most abundant of which are keratinocytes. Normal function of the epidermis requires that keratinocyte proliferation, differentiation, and apoptosis be precisely regulated and a failure to regulate these processes is a feature of many skin diseases. Although the precise …
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The Role of Tyrosine Kinase Growth Factor Receptors in Psoriatic Epidermal Hyperplasia: Analysis of Growth Factor Synergy in Cultured Human Keratinocytes and Receptor Expression in Psoriatic Skin
… receptor pathway is an important mediator of keratinocyte growth and both ligand and receptorcomponents of this pathway are abnormally expressed in hyperproliferative epidermis. In contrast, little is known about the function of other growth factor pathways in regulating keratinocyte growth. …
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Cellular and Developmental Functions of The Xenopus Arvcf-Catenin:Kazrin Complex
… families. xKazrinA is also known to influence keratinocyte proliferation-differentiation and cytoskeletal activity. In my study, I first evaluated the expression pattern of endogenous Kazrin RNA and protein in Xenopus embryogenesis as well as in adult tissues. We then collaboratively predicted …
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An in vivo study of GTF2IRD1 function and its contribution to the physical features of Williams Beuren Syndrome
… investigation of the control of epidermal proliferation, differentiation and barrier function, followed by an RNA-Seq analysis, to identify the molecular mechanisms that underpin the facial abnormalities observed in these mice. The hearing analyses revealed that Gtf2ird1 knockout mice have …
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MicroRNA-184: A Multifaceted Regulator of Epidermal Keratinocyte Biology
… insults. Consisting of dynamic outer strata of keratinocytes that terminally differentiate from basal keratinocytes stem cells (KSC), the epidermis is maintained by constant spatial and temporal control. In psoriasis, a dysregulated and intensifying crosstalk between keratinocytes and immune …
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Induction of hair follicles using neonatal mouse dermis and human keratinocytes: relevance for improved burn wound treatments
… requires the interaction between epithelial (keratinocytes) and mesenchyme cells. Attempts to recapitulate the process of hair induction in wounded skin in vitrousing human cells have to date been unsuccessful. The aim of this project is to attempt to elicit the early steps of hair follicle …
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Towards development of new strategies for inhibiting skin cancer progression
… Skin cancers are divided in two major types: (i) keratinocyte or non-melanoma skin cancers (NMSC), including basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), and (ii) melanoma.<br/><br/>Melanoma represents less than 5% of all skin cancers, however it has the highest mortality rates. …
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Mechanisms of epigenetic regulation in epidermal keratinocytes during skin development. Role of p63 transcription factor in the establishment of lineage-specific gene expression programs in keratinocytes via regulation of nuclear envelope-associated genes and Polycomb chromatin remodelling factors.
… Here we show that in p63-null mice about 32% of keratinocytes showed altered nuclear morphology. Alterations in the nuclear shape were accompanied by decreased expression of nuclear lamins (Lamin A/C and Lamin B1), proteins of the LINC complex (Sun-1, nesprin-2/3) and Plectin. Plectin links …